Production Method 1

34158-71-9

869496-60-6

Reaction Conditions

1.1 Reagents: Chlorosuccinimide Solvents: Tetrahydrofuran ,  Pyridine ;  1 h, 60 °C; 60 °C → rt
1.2 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  rt; 1.5 - 4 h, 50 - 60 °C
2.1 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  6 - 7 h, rt

Reference

Synthesis and biological evaluation of focused isoxazolylpiperidinylpiperazine library for dopamine D3 and D4 receptor antagonists

Landge, Kamalkishor P.; et al, Bulletin of the Korean Chemical Society, 2011, 32(7), 2449-2452

Production Method 2

101862-42-4

869496-60-6

Reaction Conditions

1.1 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  6 - 7 h, rt

Reference

Synthesis and biological evaluation of focused isoxazolylpiperidinylpiperazine library for dopamine D3 and D4 receptor antagonists

Landge, Kamalkishor P.; et al, Bulletin of the Korean Chemical Society, 2011, 32(7), 2449-2452

Production Method 3

587-04-2

869496-60-6

Reaction Conditions

1.1 Reagents: Hydroxyamine hydrochloride Solvents: Pyridine ;  1 - 4 h, rt
2.1 Reagents: Chlorosuccinimide Solvents: Tetrahydrofuran ,  Pyridine ;  1 h, 60 °C; 60 °C → rt
2.2 Reagents: Triethylamine Solvents: Tetrahydrofuran ;  rt; 1.5 - 4 h, 50 - 60 °C
3.1 Reagents: Silica ,  Pyridinium chlorochromate Solvents: Dichloromethane ;  6 - 7 h, rt

Reference

Synthesis and biological evaluation of focused isoxazolylpiperidinylpiperazine library for dopamine D3 and D4 receptor antagonists

Landge, Kamalkishor P.; et al, Bulletin of the Korean Chemical Society, 2011, 32(7), 2449-2452

3-(3-Chlorophenyl)isoxazole-5-carbaldehyde Raw materials

• 3-Chlorobenzaldehyde
• (3-(3-Chlorophenyl)isoxazol-5-yl)methanol
• 3-chlorobenzaldoxime

3-(3-Chlorophenyl)isoxazole-5-carbaldehyde Preparation Products

• 3-(3-Chlorophenyl)isoxazole-5-carbaldehyde (869496-60-6)

• 1. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 4. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 5. Excited state characterization of carbonyl containing carotenoids: a comparison between single and multireference descriptions?
  Riccardo Spezia,Stefan Knecht,Benedetta Mennucci Phys. Chem. Chem. Phys., 2017,19, 17156-17166

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes

• 889939-01-9(Ethanone,1-[3-(3-chlorophenyl)-5-isoxazolyl]-)
• 37091-33-1(1-(3-(4-Chlorophenyl)isoxazol-5-yl)ethanone)
• 76112-08-8(Isoxazole, 5-(3-chlorophenyl)-3-(4-methylphenyl)-)
• 651021-76-0(Isoxazole, 5-(3-chlorophenyl)-3-(4-chlorophenyl)-)
• 885273-54-1(3-(3-methylphenyl)-1,2-oxazole-5-carbaldehyde)
• 377051-52-0(3-(2-Chlorophenyl)isoxazole-5-carbaldehyde)
• 175277-36-8(1-3-(3,4-Dichlorophenyl)isoxazol-5-ylethan-1-one)
• 885273-72-3(3-(3,4-dimethylphenyl)-1,2-oxazole-5-carbaldehyde)
• 72418-40-7(3-phenyl-1,2-oxazole-5-carbaldehyde)
• 885273-60-9(3-(3,5-dimethylphenyl)-1,2-oxazole-5-carbaldehyde)