Production Method 1

43183-36-4

86298-22-8

Reaction Conditions

1.1 Solvents: Dichloromethane ,  Toluene
2.1 -

Reference

Studies on the thermal decarboxylation of 1-alkoxycarbonylbenzotriazoles

Katritzky, Alan R.; et al, Journal of Physical Organic Chemistry, 1993, 6(10), 567-73

Production Method 2

615-16-7

86298-22-8

Reaction Conditions

Reference

Product class 13: 1,2,3-triazoles

Tome, A. C., Science of Synthesis, 2004, 13, 415-601

Production Method 3

86298-22-8

Reaction Conditions

Reference

Product class 13: 1,2,3-triazoles

Tome, A. C., Science of Synthesis, 2004, 13, 415-601

Production Method 4

68985-05-7

86298-22-8

Reaction Conditions

1.1 rt

Reference

Bis(1H-benzotriazol-1-yl)-methanone

Rachwal, Stanislaw, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-2

Production Method 5

68985-05-7

86298-22-8

Reaction Conditions

Reference

Studies on the thermal decarboxylation of 1-alkoxycarbonylbenzotriazoles

Katritzky, Alan R.; et al, Journal of Physical Organic Chemistry, 1993, 6(10), 567-73

Production Method 6

68985-05-7

86298-22-8

Reaction Conditions

1.1 22 °C

Reference

Bis(1H-benzotriazol-1-yl)-methanone

Rachwal, Stanislaw, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2007, ,

Production Method 7

21050-95-3

86298-22-8

Reaction Conditions

1.1 Catalysts: [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloroc… Solvents: Acetonitrile ;  16 h, 50 bar, 70 °C

Reference

Carbonylative coupling of N-chloroamines with alcohols: synthesis of esterification reagents

Yin, Zhiping; et al, Organic & Biomolecular Chemistry, 2018, 16(15), 2643-2646

Production Method 8

95-14-7

86298-22-8

Reaction Conditions

Reference

Product class 13: 1,2,3-triazoles

Tome, A. C., Science of Synthesis, 2004, 13, 415-601

Production Method 9

95-14-7

86298-22-8

Reaction Conditions

1.1 -
2.1 rt

Reference

Bis(1H-benzotriazol-1-yl)-methanone

Rachwal, Stanislaw, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-2

Production Method 10

36772-57-3

86298-22-8

Reaction Conditions

Reference

Product class 13: 1,2,3-triazoles

Tome, A. C., Science of Synthesis, 2004, 13, 415-601

Production Method 11

95-14-7

86298-22-8

Reaction Conditions

1.1 -
2.1 rt

Reference

Bis(1H-benzotriazol-1-yl)-methanone

Rachwal, Stanislaw, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2009, 1, 1-2

Production Method 12

95-14-7

86298-22-8

Reaction Conditions

1.1 -
2.1 Catalysts: [1,3-Bis[2,6-bis(1-methylethyl)phenyl]-1,3-dihydro-2H-imidazol-2-ylidene]chloroc… Solvents: Acetonitrile ;  16 h, 50 bar, 70 °C

Reference

Carbonylative coupling of N-chloroamines with alcohols: synthesis of esterification reagents

Yin, Zhiping; et al, Organic & Biomolecular Chemistry, 2018, 16(15), 2643-2646

Production Method 13

95-14-7

86298-22-8

13351-73-0

Reaction Conditions

1.1 Catalysts: N,N,N′,N′-Tetramethylethylenediamine Solvents: Dimethylformamide ;  8 h, 95 °C; 95 °C → rt

Reference

N-Methylation of NH-Containing Heterocycles with Dimethyl Carbonate Catalyzed by TMEDA

Zhao, Sheng-Yin; et al, Synthetic Communications, 2012, 42(1), 128-135

Production Method 14

101006-59-1

86298-22-8

1271-55-2

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  10 min, -70 °C
1.2 1 h, -70 °C → rt
1.3 Reagents: Water

Reference

On the properties of the anions derived from α-deprotonation of α-(o-carboran-1-yl)- and α-ferrocenyl-1-alkylbenzotriazoles

Moiseev, S. K.; et al, Russian Chemical Bulletin, 2012, 61(10), 1933-1942

1H-Benzotriazole-1-carboxylic Acid Methyl Ester Raw materials

• 1H-Benzotriazole
• 1-Chlorobenzotriazole
• 1,2,4-Benzotriazin-3(2H)-one
• 2,3-dihydro-1H-1,3-benzodiazol-2-one
• 1-(Trimethylsilyl)-1H-benzotriazole
• Bis(benzotriazol-1-yl)methanone
• Ferrocene, [1-(1H-benzotriazol-1-yl)ethyl]-

1H-Benzotriazole-1-carboxylic Acid Methyl Ester Preparation Products

• 1-Methyl-1H-benzotriazole (13351-73-0)
• Acetylferrocene (1271-55-2)
• 1H-Benzotriazole-1-carboxylic Acid Methyl Ester (86298-22-8)

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  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
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