Production Method 1

1260112-05-7

86253-12-5

Reaction Conditions

1.1 Reagents: Silica Solvents: Water ;  1 h, rt

Reference

Practical and Modular Construction of C(sp3)-Rich Alkyl Boron Compounds

Yang, Yangyang; et al, Journal of the American Chemical Society, 2021, 143(1), 471-480

Production Method 2

86253-12-5

Reaction Conditions

1.1 Reagents: Magnesium Catalysts: 1,2-Dibromoethane Solvents: Tetrahydrofuran ;  > 0.5 h, reflux; 1 h, reflux; 17 h, rt
1.2 Reagents: Trimethyl borate Solvents: Tetrahydrofuran ;  > 0.5 h, -78 °C; < -55 °C; 2 h, rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Visible light-enabled alkylation of enol acetates with alkylboronic acids for the synthesis of α-alkyl ketones

Li, Yunpu; et al, Organic Chemistry Frontiers, 2023, 10(7), 1710-1714

Production Method 3

99810-76-1

86253-12-5

Reaction Conditions

1.1 Reagents: Potassium bifluoride Solvents: Methanol ,  Water ;  rt; 1 h, rt
2.1 Reagents: Silica Solvents: Water ;  1 - 2 h, rt

Reference

Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by K3PO4

Yue, Fuyang; et al, Chemical Science, 2022, 13(45), 13466-13474

Production Method 4

2259-30-5

86253-12-5

Reaction Conditions

1.1 Reagents: N,N-Bis(1-methylethyl)boranamine Solvents: Tetrahydrofuran ;  5 min, 0 °C; 1 h, 0 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  5 min, 0 °C; 30 min, 0 °C

Reference

Reaction of Grignard reagents with diisopropylaminoborane. Synthesis of alkyl, aryl, heteroaryl and allyl boronic acids from organo(diisopropyl)aminoborane by a simple hydrolysis

Bailey, Christopher L.; et al, Heterocycles, 2012, 86(1), 331-341

Production Method 5

677-22-5

86253-12-5

Reaction Conditions

1.1 Solvents: Diethyl ether
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Hydroboration. 84. Controlled and sequential hydroboration of simple representative alkenes with monoorganylboranes in tetrahydrofuran. A convenient synthesis of mixed borinic esters, R1R2BOR3, and mixed trialkylboranes, R1R2R3B. An examination of positional selectivity in the first and second states of hydroboration

Srebnik, Morris; et al, Journal of Organic Chemistry, 1989, 54(26), 6085-96

Production Method 6

1260112-05-7

86253-12-5

Reaction Conditions

1.1 Reagents: Silica Solvents: Water ;  1 - 2 h, rt

Reference

Alkylboronic acids as alkylating agents: photoredox-catalyzed alkylation reactions assisted by K3PO4

Yue, Fuyang; et al, Chemical Science, 2022, 13(45), 13466-13474

Production Method 7

1260112-05-7

86253-12-5

Reaction Conditions

1.1 Reagents: Water ;  1 h, rt

Reference

A practical and modular construction of C(sp3)-rich alkyl boron compounds

Yang, Yangyang; et al, ChemRxiv, 2020, 1, 1-9

tert-butylboronic acid Raw materials

• potassium tert-butyltrifluoroboranuide
• 2-(Tert-Butyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
• Magnesium, bromo(1,1-dimethylethyl)-
• Tert-Butylmagnesium chloride

tert-butylboronic acid Preparation Products

• tert-butylboronic acid (86253-12-5)

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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Boronic acid derivatives Boronic acids

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)