Cas no 86209-44-1 (2-Amino-4,6-bis(difluoromethoxy)pyrimidine)

2-Amino-4,6-bis(difluoromethoxy)pyrimidine is a versatile heterocyclic compound characterized by its difluoromethoxy substituents and amino group. Its unique structure endows it with significant advantages, including potent biological activity and tunable reactivity. This compound is highly sought after in drug discovery for its potential in inhibiting key enzymes, making it a valuable tool in medicinal chemistry research.

2-Amino-4,6-bis(difluoromethoxy)pyrimidine structure

86209-44-1 structure

Product Name:2-Amino-4,6-bis(difluoromethoxy)pyrimidine

CAS No:86209-44-1

MF:C₆H₅F₄N₃O₂

MW:227.116414785385

MDL:MFCD08669334

CID:60959

PubChem ID:13491823

Update Time:2025-06-18

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Chemical and Physical Properties

Names and Identifiers

- 2-Amino-4,6-bis(difluoromethoxy)pyrimidine
- 4,6-bis(difluoromethoxy)pyrimidin-2-amine
- 2-AMINO-4,6-DIFLUOROMETHOXYPYRIMIDINE
- 4,6-Bis(difluoromethoxy)-2-pyrimidinamine
- 4,6-Bis(difluoromethoxy)-2-pyrimidinamine (ACI)
- P9EM6J7W4U
- MFCD08669334
- 2-amino-4,6-bis-(difluoromethoxy)pyrimidine
- DTXSID90542106
- AKOS015891932
- 2-Pyrimidinamine, 4,6-bis(difluoromethoxy)-
- SCHEMBL1577067
- 4,6-bis(difluoromethoxy)-2-aminopyrimidine
- 86209-44-1
- MDL： MFCD08669334
- Inchi： 1S/C6H5F4N3O2/c7-4(8)14-2-1-3(15-5(9)10)13-6(11)12-2/h1,4-5H,(H2,11,12,13)
- InChI Key： DARNJZBBTBLNCA-UHFFFAOYSA-N
- SMILES： FC(OC1C=C(OC(F)F)N=C(N)N=1)F

Computed Properties

Exact Mass: 227.03200
Monoisotopic Mass: 227.03178906g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 5
Heavy Atom Count: 15
Rotatable Bond Count: 4
Complexity: 179
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 2.4
Topological Polar Surface Area: 70.3?2

Experimental Properties

Density: 1.527
Boiling Point: 337 oC
Flash Point: 157 oC
Refractive Index: 1.428
PSA: 70.26000
LogP: 1.84280

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Alichem	A089000767-1g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	95%	1g	$678.24	2023-08-31
Matrix Scientific	093463-250mg	2-Amino-4,6-bis(difluoromethoxy)pyrimidine, 95+%	86209-44-1	95+%	250mg	$742.00	2023-09-06
Matrix Scientific	093463-1g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine, 95+%	86209-44-1	95+%	1g	$1647.00	2023-09-06
Chemenu	CM167931-1g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	95%	1g	$729	2021-08-05
1PlusChem	1P004T72-5g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	98%	5g	$58.00	2024-04-21
1PlusChem	1P004T72-25g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	98%	25g	$145.00	2024-04-21
SHANG HAI HAO HONG Biomedical Technology Co., Ltd.	1744327-1g	4,6-Bis(difluoromethoxy)pyrimidin-2-amine	86209-44-1	98%	1g	￥6457.00	2024-04-28
A2B Chem LLC	AC23662-1g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1		1g	$1203.00	2024-04-19
Ambeed	A361090-5g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	95+%	5g	$2912.0	2025-04-16
Chemenu	CM167931-1g	2-Amino-4,6-bis(difluoromethoxy)pyrimidine	86209-44-1	95%	1g	$677	2023-02-01

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Production Method

Production Method 1

100478-26-0

86209-44-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (primisulfuron)

Wang, Jin-Ling; et al, Yingyong Huaxue, 2009, 26(4), 486-488

Production Method 2

100478-26-0

86209-44-1

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 4,6-bis(difluoromethoxy)-2-aminopyridine

Wang, Jinling; et al, Nongyao, 2008, 47(5), 346-347

Production Method 3

56-09-7

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 70 - 80 °C
1.2 4 h, 70 - 80 °C

Reference

Study on the synthesis of herbicide primisulfuron-methyl for corn farmland

Lu, Yang; et al, Jingxi Yu Zhuanyong Huaxuepin, 2006, 14(15), 13-14

Production Method 4

56-09-7

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water

Reference

Synthesis of ultrahigh effective herbicide primisulfuron-methyl

Xiao, Shenchu; et al, Huaxue Shijie, 2001, 42(7), 391-392

Production Method 5

100478-25-9

86209-44-1

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water
2.1 Reagents: Ammonia Solvents: Dichloromethane , Water

Reference

The synthesis of herbicide primisulfuron-methyl

Xiang, Dong; et al, Nongyao, 2000, 39(7),

Production Method 6

113-00-8

105-53-3

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Toluene ; rt → reflux
1.2 reflux; 4 - 5 h, reflux
1.3 Reagents: Hydrochloric acid Solvents: Water ; neutralized
2.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 70 - 80 °C
2.2 4 h, 70 - 80 °C

Reference

Study on the synthesis of herbicide primisulfuron-methyl for corn farmland

Lu, Yang; et al, Jingxi Yu Zhuanyong Huaxuepin, 2006, 14(15), 13-14

Production Method 7

504-17-6

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 10 °C
1.2 0 - 10 °C; 4 h, 0 - 10 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 - 10 °C; 1 h, 0 - 10 °C
2.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; rt → 65 °C; 4 h, 65 °C
2.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6; 2 h, 65 °C
3.1 Reagents: Acetic acid , Hydrogen peroxide Solvents: Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
4.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 4,6-bis(difluoromethoxy)-2-aminopyridine

Wang, Jinling; et al, Nongyao, 2008, 47(5), 346-347

Production Method 8

504-17-6

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide
2.1 Catalysts: Tetrabutylammonium chloride Solvents: Acetonitrile
3.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water
4.1 Reagents: Ammonia Solvents: Dichloromethane , Water

Reference

The synthesis of herbicide primisulfuron-methyl

Xiang, Dong; et al, Nongyao, 2000, 39(7),

Production Method 9

108-59-8

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol
2.1 Reagents: Sodium hydroxide
3.1 Catalysts: Tetrabutylammonium chloride Solvents: Acetonitrile
4.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water
5.1 Reagents: Ammonia Solvents: Dichloromethane , Water

Reference

The synthesis of herbicide primisulfuron-methyl

Xiang, Dong; et al, Nongyao, 2000, 39(7),

Production Method 10

100478-26-0

86209-44-1

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Dichloromethane , Water

Reference

The synthesis of herbicide primisulfuron-methyl

Xiang, Dong; et al, Nongyao, 2000, 39(7),

Production Method 11

56-09-7

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 1 h, 60 - 70 °C

Reference

Synthesis and herbicidal activity of Primisulfuron-methyl

Huang, Mingzhi, Nongyao, 2003, 42(10), 15-16

Production Method 12

56-09-7

1717-59-5

86209-44-1

Reaction Conditions

1.1 Solvents: Acetonitrile ; 3 h, 50 °C

Reference

Process for preparation of fluorine-containing herbicides

, China, , ,

Production Method 13

100478-25-9

86209-44-1

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
1.2 Reagents: Water
2.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (primisulfuron)

Wang, Jin-Ling; et al, Yingyong Huaxue, 2009, 26(4), 486-488

Production Method 14

100478-25-9

86209-44-1

Reaction Conditions

1.1 Reagents: Acetic acid , Hydrogen peroxide Solvents: Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
2.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 4,6-bis(difluoromethoxy)-2-aminopyridine

Wang, Jinling; et al, Nongyao, 2008, 47(5), 346-347

Production Method 15

113-00-8

105-53-3

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium ethoxide Solvents: Ethanol
2.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water

Reference

Synthesis of ultrahigh effective herbicide primisulfuron-methyl

Xiao, Shenchu; et al, Huaxue Shijie, 2001, 42(7), 391-392

Production Method 16

127697-72-7

86209-44-1

Reaction Conditions

1.1 Catalysts: Tetrabutylammonium chloride Solvents: Acetonitrile
2.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water
3.1 Reagents: Ammonia Solvents: Dichloromethane , Water

Reference

The synthesis of herbicide primisulfuron-methyl

Xiang, Dong; et al, Nongyao, 2000, 39(7),

Production Method 17

1979-98-2

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 4 h, rt → 65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6, rt
1.3 2 h, rt → 65 °C
2.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
2.2 Reagents: Water
3.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (primisulfuron)

Wang, Jin-Ling; et al, Yingyong Huaxue, 2009, 26(4), 486-488

Production Method 18

1979-98-2

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; rt → 65 °C; 4 h, 65 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6; 2 h, 65 °C
2.1 Reagents: Acetic acid , Hydrogen peroxide Solvents: Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
3.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 4,6-bis(difluoromethoxy)-2-aminopyridine

Wang, Jinling; et al, Nongyao, 2008, 47(5), 346-347

Production Method 19

31645-12-2

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 10 °C; 0 - 10 °C; 4 h, 0 - 10 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 - 10 °C; 1 h, 0 - 10 °C
2.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 4 h, rt → 65 °C
2.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6, rt
2.3 2 h, rt → 65 °C
3.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
3.2 Reagents: Water
4.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (primisulfuron)

Wang, Jin-Ling; et al, Yingyong Huaxue, 2009, 26(4), 486-488

Production Method 20

105-53-3

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol , Water ; 30 min, rt; 5 h, rt → 70 °C; 70 °C → rt
2.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 10 °C; 0 - 10 °C; 4 h, 0 - 10 °C
2.2 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 - 10 °C; 1 h, 0 - 10 °C
3.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; 4 h, rt → 65 °C
3.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6, rt
3.3 2 h, rt → 65 °C
4.1 Reagents: Hydrogen peroxide Solvents: Acetic acid , Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
4.2 Reagents: Water
5.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 2-[[[[[4,6-bis(difluoromethoxy)-2-pyrimidinyl]amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester (primisulfuron)

Wang, Jin-Ling; et al, Yingyong Huaxue, 2009, 26(4), 486-488

Production Method 21

105-53-3

86209-44-1

Reaction Conditions

1.1 Reagents: Sodium methoxide Solvents: Methanol ; 30 min, rt; rt → 70 °C; 5 h, 70 °C
2.1 Reagents: Sodium hydroxide Solvents: Water ; rt → 10 °C
2.2 0 - 10 °C; 4 h, 0 - 10 °C
2.3 Reagents: Hydrochloric acid Solvents: Water ; pH 2, 0 - 10 °C; 1 h, 0 - 10 °C
3.1 Reagents: Sodium hydroxide Solvents: 1,4-Dioxane , Water ; rt → 65 °C; 4 h, 65 °C
3.2 Reagents: Hydrochloric acid Solvents: Water ; pH 6; 2 h, 65 °C
4.1 Reagents: Acetic acid , Hydrogen peroxide Solvents: Water ; rt → 85 °C; 80 - 85 °C; 2 h, 80 - 85 °C
5.1 Reagents: Ammonium hydroxide Solvents: Dichloromethane , Water ; rt; 3 h, rt

Reference

Synthesis of 4,6-bis(difluoromethoxy)-2-aminopyridine

Wang, Jinling; et al, Nongyao, 2008, 47(5), 346-347

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Raw materials

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Preparation Products

2-Amino-4,6-bis(difluoromethoxy)pyrimidine (86209-44-1)

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86209-44-1 (2-Amino-4,6-bis(difluoromethoxy)pyrimidine) Related Products

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Cas no 86209-44-1 (2-Amino-4,6-bis(difluoromethoxy)pyrimidine)

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Chemical and Physical Properties

Names and Identifiers

Computed Properties

Experimental Properties

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Pricemore >>

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Production Method

Production Method 1

Production Method 2

Production Method 3

Production Method 4

Production Method 5

Production Method 6

Production Method 7

Production Method 8

Production Method 9

Production Method 10

Production Method 11

Production Method 12

Production Method 13

Production Method 14

Production Method 15

Production Method 16

Production Method 17

Production Method 18

Production Method 19

Production Method 20

Production Method 21

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Raw materials

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Preparation Products

2-Amino-4,6-bis(difluoromethoxy)pyrimidine Related Literature

86209-44-1 (2-Amino-4,6-bis(difluoromethoxy)pyrimidine) Related Products