Production Method 1

673-06-3

86117-53-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  10 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Synthetically amenable amide derivatives of tosylated-amino acids as organocatalysts for enantioselective allylation of aldehydes: computational rationale for enantioselectivity

Ghosh, Debashis; et al, Organic & Biomolecular Chemistry, 2013, 11(21), 3451-3460

Production Method 2

86117-53-5

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Tempo ,  Cupric nitrate ,  Potassium bisulfate Solvents: 1,2-Dichloroethane ;  24 h, rt

Reference

Copper-catalyzed aerobic oxidation of primary alcohols to carboxylic acids

Yu, Yibo; et al, Chemical Communications (Cambridge, 2023, 59(35), 5281-5284

Production Method 3

673-06-3

86117-53-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  rt; 6 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  < 7 °C

Reference

Multi-step application of immobilized reagents and scavengers: A total synthesis of epothilone C

Storer, R. Ian; et al, Chemistry - A European Journal, 2004, 10(10), 2529-2547

Production Method 4

673-06-3

86117-53-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, rt

Reference

Allylation of Aldehydes and Imines: Promoted by Reusable Polymer-Supported Sulfonamide of N-Glycine

Li, Gui-Long; et al, Organic Letters, 2006, 8(4), 633-636

Production Method 5

63-91-2

86117-53-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Water ;  25 °C; overnight, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

Carbonic anhydrase inhibitors: Design, synthesis, kinetic, docking and molecular dynamics analysis of novel glycine and phenylalanine sulfonamide derivatives

Fidan, Ismail; et al, Bioorganic & Medicinal Chemistry, 2015, 23(23), 7353-7358

Production Method 6

34635-34-2

86117-53-5

13505-32-3

Reaction Conditions

1.1 Reagents: (3R,5R,6S,8R)-1,3,4,5,6,7,8,10-Octahydro-5,6-bis(2-hydroxyphenyl)-3,8-bis(phenyl… Solvents: Chloroform-d ;  rt

Reference

Synthesis of macrocycles and their application as chiral solvating agents in the enantiomeric recognition of carboxylic acids and α-amino acid derivatives

Guo, Shengnan; et al, Tetrahedron: Asymmetry, 2013, 24(8), 480-491

N-[(4-Methylphenyl)sulfonyl]-D-phenylalanine Raw materials

• L-Phenylalanine
• 2-((4-Methylphenyl)sulfonylamino)-3-phenylpropanoic Acid
• D-Phenylalanine

N-[(4-Methylphenyl)sulfonyl]-D-phenylalanine Preparation Products

• N-(p-Toluenesulfonyl)-L-phenylalanine (13505-32-3)
• N-[(4-Methylphenyl)sulfonyl]-D-phenylalanine (86117-53-5)

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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)