Cas no 860299-05-4 (6-(pyrrolidin-2-yl)quinoline)

6-(Pyrrolidin-2-yl)quinoline is a heterocyclic compound featuring a quinoline core substituted with a pyrrolidine moiety at the 6-position. This structural motif imparts unique electronic and steric properties, making it a valuable intermediate in medicinal chemistry and material science. The pyrrolidine ring enhances conformational flexibility and potential binding affinity, while the quinoline scaffold offers stability and π-conjugation. This compound is particularly useful in the synthesis of bioactive molecules, including kinase inhibitors and fluorescent probes, due to its ability to modulate electronic interactions. Its well-defined reactivity profile allows for further functionalization, enabling tailored applications in drug discovery and optoelectronic materials.
6-(pyrrolidin-2-yl)quinoline structure
6-(pyrrolidin-2-yl)quinoline structure
Product Name:6-(pyrrolidin-2-yl)quinoline
CAS No:860299-05-4
MF:C13H14N2
MW:198.263662815094
MDL:MFCD06660471
CID:718148
PubChem ID:16740810
Update Time:2025-11-01

6-(pyrrolidin-2-yl)quinoline Chemical and Physical Properties

Names and Identifiers

    • Quinoline,6-(2-pyrrolidinyl)-
    • 6-(2-pyrrolidinyl)Quinoline
    • 6-pyrrolidin-2-ylquinoline
    • 6-PYRROLIDIN-2-YL-QUINOLINE
    • 6-(pyrrolidin-2-yl)quinoline
    • GL-0497
    • Quinoline,6-(2-pyrrolidinyl)
    • SCHEMBL19580316
    • 860299-05-4
    • FT-0739457
    • EN300-1851434
    • AKOS005257037
    • MFCD06660471
    • DTXSID10587695
    • MDL: MFCD06660471
    • Inchi: 1S/C13H14N2/c1-3-10-9-11(12-4-2-8-14-12)5-6-13(10)15-7-1/h1,3,5-7,9,12,14H,2,4,8H2
    • InChI Key: QHBYGJLVFNLHRB-UHFFFAOYSA-N
    • SMILES: N1CCCC1C1C=CC2C(=CC=CN=2)C=1

Computed Properties

  • Exact Mass: 198.11600
  • Monoisotopic Mass: 198.115698455g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 15
  • Rotatable Bond Count: 1
  • Complexity: 217
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 2.1
  • Topological Polar Surface Area: 24.9?2

Experimental Properties

  • PSA: 24.92000
  • LogP: 2.98810

6-(pyrrolidin-2-yl)quinoline Customs Data

  • HS CODE:2933990090
  • Customs Data:

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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Additional information on 6-(pyrrolidin-2-yl)quinoline

Exploring the Chemical and Pharmaceutical Potential of 6-(pyrrolidin-2-yl)quinoline (CAS No. 860299-05-4)

The compound 6-(pyrrolidin-2-yl)quinoline (CAS No. 860299-05-4) has garnered significant attention in recent years due to its unique structural features and potential applications in medicinal chemistry. As a quinoline derivative, it belongs to a class of heterocyclic compounds known for their diverse biological activities. The presence of a pyrrolidine ring at the 6-position of the quinoline scaffold enhances its molecular complexity, making it a promising candidate for drug discovery and development.

Researchers have been particularly interested in 6-(pyrrolidin-2-yl)quinoline due to its potential role in targeting various biological pathways. Recent studies suggest that quinoline-based compounds exhibit antimicrobial, anticancer, and anti-inflammatory properties. The incorporation of the pyrrolidine moiety may further modulate these activities, offering improved selectivity and efficacy. This has led to increased searches for "quinoline derivatives in drug discovery" and "pyrrolidine-containing bioactive compounds" across scientific databases and AI-powered research tools.

From a synthetic chemistry perspective, 6-(pyrrolidin-2-yl)quinoline presents interesting challenges and opportunities. The compound's CAS registry number (860299-05-4) serves as a unique identifier in chemical databases, facilitating research collaboration and data sharing. Current trends in organic synthesis emphasize the development of efficient routes to such N-heterocyclic compounds, with many researchers exploring green chemistry approaches to their preparation. This aligns with growing interest in "sustainable synthesis of pharmaceutical intermediates" and "eco-friendly heterocyclic compound production".

The physicochemical properties of 6-(pyrrolidin-2-yl)quinoline contribute to its pharmaceutical potential. The quinoline core provides aromatic character and planarity, while the pyrrolidine substituent introduces stereochemical complexity and potential for hydrogen bonding. These features influence the compound's solubility, permeability, and overall drug-likeness, making it relevant to current discussions about "molecular properties in drug design" and "structural optimization of lead compounds". Computational chemistry and molecular modeling approaches are increasingly being applied to understand and predict the behavior of such molecules.

In the context of current pharmaceutical research, 6-(pyrrolidin-2-yl)quinoline represents an important structural motif. The global focus on novel therapeutic agents has driven interest in "quinoline-based drug candidates" and "small molecule modulators of biological targets". Its structural features suggest potential applications in central nervous system disorders, given the known pharmacological profiles of both quinoline and pyrrolidine containing compounds. This connection has led to increased searches for "neuroactive heterocyclic compounds" and "CNS drug development strategies".

Quality control and analytical characterization of 6-(pyrrolidin-2-yl)quinoline (CAS No. 860299-05-4) remain crucial aspects of its research and potential application. Modern analytical techniques such as HPLC-MS, NMR spectroscopy, and X-ray crystallography are essential for verifying the compound's purity and structure. This aligns with industry demands for "advanced characterization of pharmaceutical intermediates" and "quality assurance in chemical synthesis", topics that frequently appear in scientific literature and patent applications.

The future research directions for 6-(pyrrolidin-2-yl)quinoline may include exploration of its structure-activity relationships, development of novel analogs, and investigation of its mechanism of action. As the pharmaceutical industry continues to seek innovative solutions for unmet medical needs, compounds like 6-(pyrrolidin-2-yl)quinoline will likely remain at the forefront of medicinal chemistry research. The growing body of work in this area reflects broader trends toward "rational drug design" and "targeted molecular therapeutics", ensuring continued relevance in both academic and industrial settings.

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