Production Method 1

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Acetone ;  3 - 4 h, 25 - 35 °C

Reference

Preparation of salmeterol and salts thereof

, India, , ,

Production Method 2

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Methanol ;  1 h, 30 °C; 30 °C → 22 °C; 2 h, 18 - 22 °C

Reference

Improved process for the preparation of salmeterol xinafoate

, India, , ,

Production Method 3

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Isopropanol ;  rt → 70 °C; 8 h, 70 °C

Reference

Synthesis route of salmeterol xinafoate

Jiang, Zhi-gan; Hua, Zheng-mao; Mai, Lu-gen; Yang, Li-ge, Huadong Shifan Daxue Xuebao, 2003, (3), 102-104

Production Method 4

86-48-6

89365-50-4

Reaction Conditions

Reference

Preparation of salmeterol and its application

, China, , ,

Production Method 5

86-48-6

89365-50-4

Reaction Conditions

Reference

Utility of Von Pechman synthesis of coumarin reaction for development of spectrofluorimetric method for quantitation of salmeterol xinafoate in pharmaceutical preparations and human plasma

Awad, Mohamed; Hammad, Mohamed A. ; Abdel-Megied, Ahmed M. ; Omar, Mahmoud A., Luminescence, 2018, 33(5), 913-918

Production Method 6

86-48-6

89365-50-4

Reaction Conditions

Reference

Improved process for the preparation A Long-acting β2-adrenergic agonist (LABA) Salmeterol and identification, characterization and control of its potential process impurity

Reddy, Sahadeva; Rajan, S. T.; Parusuramudu; Reddy, Raghupathi; Chakravarthy, I. E., Pharma Chemica, 2016, 8(8), 28-35

Production Method 7

86-48-6

89365-50-4

Reaction Conditions

Reference

Process for preparation of salmeterol

, India, , ,

Production Method 8

86-48-6

89365-50-4

Reaction Conditions

Reference

An improved process for the preparation of salmeterol xinafoate

, India, , ,

Production Method 9

86-48-6

89365-50-4

Reaction Conditions

Reference

Phenethanolamine derivatives useful in the treatment of respiratory problems

, Federal Republic of Germany, , ,

Production Method 10

574-96-9

86-48-6

Reaction Conditions

1.1 Reagents: Oxygen Solvents: Water ;  rt → 37 °C; 24 h, pH 7, 1 atm, 37 °C

Reference

Catalyst-free aerobic oxidation of aldehydes into acids in water under mild conditions

Zhang, Yue; et al, Green Chemistry, 2017, 19(23), 5708-5713

Production Method 11

17201-44-4

90-15-3

86-48-6

Reaction Conditions

1.1 4 h, 1.2 - 1.4 atm, rt → 160 °C; 1 h, 160 °C
1.2 Reagents: Hydrochloric acid Solvents: Water

Reference

Carboxylation of naphthols with sodium ethyl carbonate

Suerbaev, Kh. A.; et al, Neftekhimiya, 2005, 45(5), 364-366

Production Method 12

17201-44-4

90-15-3

86-48-6

Reaction Conditions

1.1 Reagents: Oxygen ;  1 h, rt → 60 °C; 4 h, 1.2 - 1.4 atm, 60 °C → 160 °C; 1 h, 160 °C; 160 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, rt

Reference

Carboxylation of hydroxyarenes with metal alkyl carbonates

Suerbaev, Khakim A.; et al, Green Processing and Synthesis, 2015, 4(2), 91-96

Production Method 13

121453-00-7

86-48-6

86-48-6

Reaction Conditions

1.1 Reagents: Triethylamine ,  Iron perchlorate hexahydrate Solvents: Methanol ;  rt; 4 h, rt

Reference

Mimicking the Aromatic-Ring-Cleavage Activity of Gentisate-1,2-Dioxygenase by a Nonheme Iron Complex

Rahaman, Rubina; et al, Angewandte Chemie, 2016, 55(44), 13838-13842

Production Method 14

1344113-50-3

86-48-6

Reaction Conditions

1.1 Reagents: 2,2,2-Trifluoroethanol ,  Silver acetate Catalysts: Palladium diacetate ,  BOC-L-leucine Solvents: 1,2-Dichloroethane ;  5 min, 95 °C; 18 h, 95 °C
1.2 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  30 min, rt

Reference

General Method for the Synthesis of Salicylic Acids from Phenols through Palladium-Catalyzed Silanol-Directed C-H Carboxylation

Wang, Yang; et al, Angewandte Chemie, 2015, 54(7), 2255-2259

Production Method 15

90-15-3

86-48-6

Reaction Conditions

1.1 Reagents: Ethyl bromide ,  Magnesium Solvents: Diethyl ether
1.2 Solvents: Carbon disulfide
1.3 Reagents: Ammonium chloride Solvents: Water

Reference

Metal template ortho-acylation of phenols. Direct synthesis of salicylic acid chlorides and derivatives

Sartori, Giovanni; et al, Synthesis, 1988, (10), 763-6

Production Method 16

86-48-6

Reaction Conditions

1.1 Solvents: Carbon disulfide
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Metal template ortho-acylation of phenols. Direct synthesis of salicylic acid chlorides and derivatives

Sartori, Giovanni; et al, Synthesis, 1988, (10), 763-6

Production Method 17

7732-44-7

86-48-6

Reaction Conditions

1.1 Catalysts: Ethyl acetoacetate

Reference

Studies on 1-hydroxy-2-naphthoic and 3-hydroxy-2-naphthoic acid hydrazides

Pant, U. C.; et al, Revue Roumaine de Chimie, 1979, 24(3), 471-82

Production Method 18

90-15-3

86-48-6

Reaction Conditions

1.1 Reagents: Triethylaluminum Solvents: Diethyl ether ,  Hexane
2.1 Solvents: Carbon disulfide
2.2 Reagents: Ammonium chloride Solvents: Water

Reference

Metal template ortho-acylation of phenols. Direct synthesis of salicylic acid chlorides and derivatives

Sartori, Giovanni; et al, Synthesis, 1988, (10), 763-6

Production Method 19

86-48-6

Reaction Conditions

1.1 -
2.1 Reagents: Oxygen ;  1 h, rt → 60 °C; 4 h, 1.2 - 1.4 atm, 60 °C → 160 °C; 1 h, 160 °C; 160 °C → rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2, rt

Reference

Carboxylation of hydroxyarenes with metal alkyl carbonates

Suerbaev, Khakim A.; et al, Green Processing and Synthesis, 2015, 4(2), 91-96

Production Method 20

80317-59-5

3401-47-6

86-48-6

Reaction Conditions

1.1 Reagents: Magnesium ,  Dibromoethane Solvents: Diethyl ether ,  Benzene ;  heated; overnight, reflux
1.2 Solvents: Benzene ;  1 h, reflux
1.3 Reagents: Ammonium chloride Solvents: Water
2.1 Reagents: Hydrochloric acid Solvents: Water ;  36 h, reflux

Reference

Synthesis of chiral binaphthyl derivatives

Wilson, Janet M., 1981, , ,

Production Method 21

86-48-6

Reaction Conditions

1.1 Reagents: Magnesium ,  Iodine ,  Dibromoethane ,  2-(1-Bromo-2-naphthalenyl)-4,5-dihydro-4,4-dimethyloxazole Solvents: Diethyl ether ;  5 h, reflux
1.2 Solvents: Tetrahydrofuran ;  13 h, reflux
1.3 Reagents: Ammonium chloride Solvents: Water
2.1 Reagents: Hydrochloric acid Solvents: Water ;  36 h, reflux

Reference

Synthesis of chiral binaphthyl derivatives

Wilson, Janet M., 1981, , ,

Production Method 22

93530-92-8

101143-87-7

86-48-6

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  4 h, rt; rt → 60 °C; 24 h, 60 °C
1.2 18 h, 56 °C
1.3 Reagents: Ammonium chloride Solvents: Water ;  neutralized
1.4 Reagents: Hydrochloric acid Solvents: Water
2.1 Reagents: Magnesium ,  Dibromoethane Solvents: Diethyl ether ,  Benzene ;  overnight, reflux
2.2 Solvents: Benzene ;  45 min, reflux; reflux → rt
2.3 Reagents: Ammonium chloride Solvents: Water
3.1 Reagents: Hydrochloric acid Solvents: Water ;  36 h, reflux

Reference

Synthesis of chiral binaphthyl derivatives

Wilson, Janet M., 1981, , ,

Production Method 23

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Methyl ethyl ketone ;  rt

Reference

Process for the preparation of salmeterol xinafoate from 2-(bromoethyl)benzene

, China, , ,

Production Method 24

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Acetone ;  40 min, 30 °C

Reference

Preparation method of salmeterol xinafoate

, China, , ,

Production Method 25

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Acetone ;  30 min, 45 °C; 45 °C → 25 °C; 1 h, 25 °C
1.2 Solvents: tert-Butyl methyl ether ;  25 °C → 10 °C; 2 h, 10 °C

Reference

Process for preparation of salmeterol

, World Intellectual Property Organization, , ,

Production Method 26

934842-69-0

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Ethanol ;  rt

Reference

A new route for synthesis of salmeterol xinafoate

Wu, Xiaochun, Xinan Shifan Daxue Xuebao, 2009, 34(4), 85-88

Production Method 27

262857-01-2

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Reagents: Acetic acid Solvents: Water ;  3 h, 70 °C
1.2 Solvents: Ethyl acetate ;  16 h, rt

Reference

Preparation of deuterium substituted ethanolamines as adrenergic modulators for disease treatment

, United States, , ,

Production Method 28

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Methanol ;  25 - 30 °C; 3 h, 0 °C

Reference

A method for preparing salmeterol hydroxynaphthoate

, China, , ,

Production Method 29

89365-50-4

86-48-6

86-48-6

89365-50-4

Reaction Conditions

1.1 Solvents: Methanol ,  Ethyl acetate

Reference

Preparation of salmeterol xinafolate

Anonymous, Research Disclosure, 2006, 506,

Production Method 30

86-48-6

89365-50-4

Reaction Conditions

Reference

Process for the preparation of crystalline salmeterol and its xinafoate salt

, World Intellectual Property Organization, , ,

Production Method 31

86-48-6

89365-50-4

Reaction Conditions

Reference

Process for preparation of salmeterol xinafoate

, World Intellectual Property Organization, , ,

Production Method 32

86-48-6

89365-50-4

Reaction Conditions

Reference

Medicaments containing betamimetic drugs and a novel anticholinesterase drug for treating respiratory tract diseases

, World Intellectual Property Organization, , ,

Production Method 33

90-15-3

86-48-6

Reaction Conditions

1.1 Solvents: 3-Methoxybutanol

Reference

Process for preparation of aromatic carboxylic acids by carboxylation of aromatic compounds in alkoxyalkanols as solvents

, European Patent Organization, , ,

Production Method 34

90-15-3

4861-79-4

86-48-6

Reaction Conditions

1.1 Solvents: Dimethylformamide

Reference

An efficient carboxylation of 1-naphthols using magnesium methyl carbonate

Cate, Laurence A., Synthesis, 1983, (5), 385-6

Production Method 35

17201-44-4

90-15-3

86-48-6

Reaction Conditions

1.1 4 h, 1 atm → 1.1 atm, rt → 160 °C; 1 h, 1.1 - 1.2 atm, 160 °C; 160 °C → rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

Carboxylation of hydroxy arenes by alkaline metal salts of ethylcarbonic acid

Shalmagambetov, K. M.; et al, Khimicheskaya Tekhnologiya (Moscow, 2011, 12(10), 598-603

Production Method 36

345621-89-8

86-48-6

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Water ;  36 h, reflux

Reference

Synthesis of chiral binaphthyl derivatives

Wilson, Janet M., 1981, , ,

Production Method 37

19402-71-2

86-48-6

Reaction Conditions

1.1 Solvents: Nitrobenzene

Reference

The carboxylation of naphthols by Kolbe-Schmitt reaction in the homogeneous solution

Yamaguchi, Tatsuaki; et al, Nippon Kagaku Kaishi, 1989, (7), 1164-5

Production Method 38

90-15-3

298-14-6

86-48-6

Reaction Conditions

1.1 Catalysts: Decarboxylase Solvents: Acetonitrile ,  Water ;  24 h, pH 8.5, 30 °C

Reference

Regioselective Enzymatic Carboxylation of Phenols and Hydroxystyrene Derivatives

Wuensch, Christiane; et al, Organic Letters, 2012, 14(8), 1974-1977

Production Method 39

90-15-3

86-48-6

Reaction Conditions

Reference

1-Hydroxy-2-naphthoic acid

, Romania, , ,

Production Method 40

90-15-3

86-48-6

Reaction Conditions

1.1 Reagents: Sodium bicarbonate ,  Potassium bicarbonate Solvents: Water

Reference

Synthesis of menadione

Rao, A. V. Rama; et al, Indian Journal of Chemistry, 1985, (3), 233-5

Production Method 41

80373-29-1

3401-47-6

86-48-6

Reaction Conditions

1.1 Reagents: Magnesium ,  Dibromoethane Solvents: Diethyl ether ,  Benzene ;  overnight, reflux
1.2 Solvents: Benzene ;  45 min, reflux; reflux → rt
1.3 Reagents: Ammonium chloride Solvents: Water
2.1 Reagents: Hydrochloric acid Solvents: Water ;  36 h, reflux

Reference

Synthesis of chiral binaphthyl derivatives

Wilson, Janet M., 1981, , ,

Production Method 42

94403-14-2

90-15-3

86-48-6

Reaction Conditions

1.1 Reagents: Imidazole Solvents: Dimethylformamide ;  0 °C; 30 min, rt
1.2 Solvents: Dimethylformamide ;  0 °C; overnight, rt
2.1 Reagents: 2,2,2-Trifluoroethanol ,  Silver acetate Catalysts: Palladium diacetate ,  BOC-L-leucine Solvents: 1,2-Dichloroethane ;  5 min, 95 °C; 18 h, 95 °C
2.2 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  30 min, rt

Reference

General Method for the Synthesis of Salicylic Acids from Phenols through Palladium-Catalyzed Silanol-Directed C-H Carboxylation

Wang, Yang; et al, Angewandte Chemie, 2015, 54(7), 2255-2259

1-hydroxynaphthalene-2-carboxylic acid Raw materials

• 1-Naphthalenol,potassium salt (1:1)
• Borate(1-), tris(3,5-diphenyl-1H-pyrazolato-κN1)hydro-, potassium (1:1), (T-4)-
• Silane, dibromobis(1,1-dimethylethyl)-
• (-)-2-(2-(1-(3R,4S,8R,9S)-quinidinoxynaphthyl))-4,4-dimethyl-Δ2-oxazoline
• Salmeterol
• Carbonic acid, monoethyl ester, sodium salt
• naphthalen-1-ol
• 1-Hydroxy-2-naphthaldehyde
• Magnesium Methyl Carbonate Solution (2.0 M in DMF)
• 1,3-Benzenedimethanol,4-hydroxy-a1-6-(4-phenylbutoxy)hexyl(phenylmethyl)aminomethyl-
• (-)-2-[2-(1-(1R,3R,4S)-menthoxynaphthyl)]-4,4-dimethyl-Δ2-oxazoline
• 2-(2-(1-bromonaphthyl))-4,4-dimethyl-Δ2-oxazoline
• 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)-1-naphthalenol
• (S)-(2R,4S,5S)-5-ethenyl-1-azabicyclo2.2.2octan-2-yl(6-methoxyquinolin-4-yl)methanol
• 4H-1,3-Benzodioxin-6-methanol, 2,2-dimethyl-alpha-[[[6-(4-phenylbutoxy)hexyl]amino]methyl]-
• 1-hydroxynaphthalene-2-carbohydrazide
• 1-hydroxynaphthalene-2-carboxylic acid
• Potassium bicarbonate
• Silanol, 1,1-bis(1,1-dimethylethyl)-1-(1-naphthalenyloxy)-
• 1-Bromo-2-methoxy-naphthalene

1-hydroxynaphthalene-2-carboxylic acid Preparation Products

• Salmeterol (89365-50-4)
• 1-hydroxynaphthalene-2-carboxylic acid (86-48-6)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Benzenoids Naphthalenes Naphthalenecarboxylic acids and derivatives Naphthalenecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Exploring the Versatile Applications and Properties of 1-Hydroxynaphthalene-2-Carboxylic Acid (CAS No. 86-48-6)

1-Hydroxynaphthalene-2-carboxylic acid (CAS No. 86-48-6) is a significant organic compound widely recognized in the chemical and pharmaceutical industries. This compound, also known as 2-hydroxy-1-naphthoic acid, belongs to the naphthalene derivatives family and exhibits unique chemical properties that make it valuable in various applications. Its molecular structure, featuring both hydroxyl and carboxylic acid functional groups, allows it to participate in diverse chemical reactions, making it a versatile intermediate in organic synthesis.

The growing interest in 1-hydroxynaphthalene-2-carboxylic acid uses stems from its role in the production of dyes, pigments, and pharmaceutical intermediates. Researchers and industry professionals frequently search for 1-hydroxynaphthalene-2-carboxylic acid synthesis methods and 1-hydroxynaphthalene-2-carboxylic acid solubility data to optimize its application in different processes. The compound's solubility in organic solvents like ethanol and acetone makes it particularly useful in formulations requiring precise chemical interactions.

One of the most searched topics related to this compound is its 1-hydroxynaphthalene-2-carboxylic acid biological activity. Recent studies have explored its potential as a building block for bioactive molecules, including antimicrobial and anti-inflammatory agents. The compound's structural features allow for modifications that can enhance its efficacy in drug development, aligning with the current trend in green chemistry and sustainable pharmaceutical synthesis.

In the field of material science, 1-hydroxynaphthalene-2-carboxylic acid is gaining attention for its role in developing advanced polymers and coatings. Its ability to form stable complexes with metal ions makes it valuable in creating functional materials with tailored properties. Industry experts often inquire about 1-hydroxynaphthalene-2-carboxylic acid suppliers and 1-hydroxynaphthalene-2-carboxylic acid price trends, reflecting its commercial importance.

The compound's stability under various conditions is another area of interest. Many researchers look for information on 1-hydroxynaphthalene-2-carboxylic acid stability and storage recommendations to ensure optimal performance in industrial applications. Proper handling and storage in cool, dry environments are essential to maintain its chemical integrity over time.

Environmental considerations are increasingly important in chemical usage, and 1-hydroxynaphthalene-2-carboxylic acid environmental impact is a frequently searched topic. The compound's biodegradability and potential effects on ecosystems are subjects of ongoing research, particularly in the context of eco-friendly chemical processes and waste management strategies.

Analytical chemists often seek information about 1-hydroxynaphthalene-2-carboxylic acid detection methods and analytical standards. Techniques such as HPLC and GC-MS are commonly employed to quantify and characterize this compound in various matrices, ensuring quality control in industrial applications.

The future prospects of 1-hydroxynaphthalene-2-carboxylic acid look promising, with emerging applications in nanotechnology and renewable energy sectors. Its potential use in organic electronics and energy storage materials is currently under investigation, reflecting the compound's adaptability to cutting-edge technologies.

For researchers working with this compound, understanding its spectroscopic properties is crucial. The characteristic IR and NMR spectra of 1-hydroxynaphthalene-2-carboxylic acid serve as important tools for identification and purity assessment, making these analytical techniques essential in quality assurance protocols.

As the demand for specialized organic compounds grows, 1-hydroxynaphthalene-2-carboxylic acid continues to attract attention from both academic and industrial circles. Its multifaceted applications, from traditional chemical synthesis to innovative material science, ensure its ongoing relevance in the evolving landscape of chemical research and development.

• 92-70-6(3-Hydroxy-2-naphthoic acid)
• 83511-07-3(3,7-Dihydroxy-2-naphthoic acid)
• 117978-18-4(2-Phenanthrenecarboxylicacid, 3-hydroxy-)
• 117978-17-3(3-Phenanthrenecarboxylicacid, 2-hydroxy-)
• 154030-54-3(1,6-Naphthalenedicarboxylicacid, 2,5-dihydroxy-)
• 89-35-0(3,5-Dihydroxynapthalene-2-carboxylic Acid)
• 160592-73-4(H3ondc)
• 25543-68-4(1,5-Dihydroxynaphthalene-2,6-dicarboxylic Acid)
• 31519-22-9(1,4-Dihydroxy-2-naphthoic acid)
• 108239-90-3(2-Anthracenecarboxylicacid, 1-hydroxy-)