Production Method 1

23012-14-8

6638-79-5

859046-10-9

Reaction Conditions

1.1 Reagents: Chlorodimethylaluminum Solvents: Dichloromethane ;  0 °C; 0 °C → rt; 90 min, rt
1.2 Solvents: Dichloromethane ;  rt; 90 min, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 7, cooled
2.1 Solvents: Tetrahydrofuran ;  0 °C; 1 h, 0 °C
2.2 Reagents: Ammonium chloride Solvents: Water ;  0 °C

Reference

Total Synthesis of (+)-Ileabethoxazole via an Iron-Mediated Pauson-Khand [2 + 2 + 1] Carbocyclization

Williams, David R.; et al, Journal of the American Chemical Society, 2014, 136(24), 8829-8836

Production Method 2

170486-48-3

859046-10-9

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  0 °C; 1 h, 0 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  0 °C

Reference

Total Synthesis of (+)-Ileabethoxazole via an Iron-Mediated Pauson-Khand [2 + 2 + 1] Carbocyclization

Williams, David R.; et al, Journal of the American Chemical Society, 2014, 136(24), 8829-8836

1-(1,3-oxazol-4-yl)ethan-1-one Raw materials

• Ethyl 1,3-oxazole-4-carboxylate
• N,O-Dimethylhydroxylamine hydrochloride
• Oxazole-4-carboxylic acid methoxymethylamide

1-(1,3-oxazol-4-yl)ethan-1-one Preparation Products

• 1-(1,3-oxazol-4-yl)ethan-1-one (859046-10-9)

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• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

• 947145-29-1(Oxazole, 4-(1-methylethyl)-)
• 128979-15-7(4-benzoyl-1,3-oxazole)
• 81740-16-1(1-(2-methyloxazol-4-yl)ethanone)
• 1510062-36-8(Ethanone, 1-(2-bromo-4-oxazolyl)-)
• 2092562-64-4(1-Propanone, 1-(4-oxazolyl)-)
• 54300-20-8(4-ethyl-1,3-oxazole)
• 1216314-67-8(2-Chloro-1-(1,3-oxazol-4-yl)ethanone)
• 118994-84-6(1,3-oxazole-4-carbaldehyde)
• 1539973-82-4(1-2-(propan-2-yl)-1,3-oxazol-4-ylethan-1-one)
• 170486-49-4(Methanone, bis(4-oxazolyl)-)