Production Method 1

26307-50-6

859034-02-9

Reaction Conditions

1.1 Reagents: Triethylamine Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: Methanol ;  16 h, 500 psi, rt → 120 °C
1.2 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  overnight, rt; rt

Reference

Discovery, Structure-Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua; et al, Journal of Medicinal Chemistry, 2006, 49(12), 3520-3535

Production Method 2

859034-02-9

Reaction Conditions

1.1 Reagents: Tetrabutylammonium tribromide Solvents: Methanol ,  Dichloromethane ;  rt
2.1 Reagents: Triethylamine Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: Methanol ;  16 h, 500 psi, rt → 120 °C
2.2 Reagents: Sodium hydroxide Solvents: Tetrahydrofuran ,  Water ;  overnight, rt; rt

Reference

Discovery, Structure-Activity Relationship, and Pharmacological Evaluation of (5-Substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as Potent Dipeptidyl Peptidase IV Inhibitors

Pei, Zhonghua; et al, Journal of Medicinal Chemistry, 2006, 49(12), 3520-3535

4-hydroxy-3-(propan-2-yl)benzoic acid Raw materials

• 4-Bromo-2-(1-methylethyl)phenol

4-hydroxy-3-(propan-2-yl)benzoic acid Preparation Products

• 4-hydroxy-3-(propan-2-yl)benzoic acid (859034-02-9)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Hydroxybenzoic acid derivatives
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Hydroxybenzoic acid derivatives

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