• 1. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
  Xue-Ying Wang,Ying Pei,Min Xie,Zi-He Jin,Ya-Shi Xiao,Yang Wang,Li-Na Zhang,Yan Li,Wei-Hua Huang Lab Chip, 2015,15, 1178-1187
• 2. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
  M. T. Colomer,S. Díaz-Moreno,A. Tamayo,A. L. Ortiz J. Mater. Chem. C, 2018,6, 12643-12651
• 3. An integrated system for field analysis of Cd(ii) and Pb(ii) via preconcentration using nano-TiO2/cellulose paper composite and subsequent detection with a portable X-ray fluorescence spectrometer?
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• 4. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
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• 5. An analysis of the WTC fires using CIB correlations and simple modeling
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonyl compounds Benzenesulfonyl halides

Comprehensive Overview of 3-Methoxy-2-methylbenzene-1-sulfonyl chloride (CAS No. 858842-11-2)

3-Methoxy-2-methylbenzene-1-sulfonyl chloride (CAS No. 858842-11-2) is a specialized sulfonyl chloride derivative widely utilized in organic synthesis and pharmaceutical research. This compound, characterized by its methoxy and methyl substituents on the benzene ring, serves as a critical intermediate for constructing complex molecules. Its unique structure enables applications in peptide coupling, polymer chemistry, and catalyst design, aligning with current trends in sustainable chemistry and green synthesis.

The growing demand for high-purity sulfonyl chlorides in drug discovery has spotlighted compounds like 3-Methoxy-2-methylbenzene-1-sulfonyl chloride. Researchers frequently search for "sulfonation reagents," "benzene derivatives in medicinal chemistry," or "CAS 858842-11-2 applications," reflecting its relevance in API development and bioconjugation. Recent studies highlight its role in click chemistry and metal-organic frameworks (MOFs), addressing industry needs for efficient crosslinking agents.

From a synthetic perspective, the electron-donating methoxy group in 3-Methoxy-2-methylbenzene-1-sulfonyl chloride enhances its reactivity in nucleophilic substitution reactions. This property is exploited in designing fluorescent probes and photoactive materials, topics trending in materials science forums. Analytical techniques like HPLC-MS and NMR spectroscopy confirm its stability under controlled conditions, making it suitable for high-throughput screening workflows.

Environmental considerations have spurred interest in "biodegradable sulfonylating agents" and "low-toxicity benzene derivatives." While 858842-11-2 requires standard laboratory precautions, its controlled use in microwave-assisted synthesis reduces solvent waste—a key concern in green chemistry discussions. Patent analyses reveal its incorporation in OLED materials and agrochemical formulations, demonstrating versatility beyond traditional applications.

Storage recommendations for 3-Methoxy-2-methylbenzene-1-sulfonyl chloride emphasize anhydrous conditions and temperature-controlled environments, common queries among industrial users. Comparative studies with analogous compounds (e.g., tosyl chloride derivatives) show superior selectivity in asymmetric synthesis, a hot topic in catalysis research. The compound’s chromatographic purification protocols are frequently optimized for scale-up production, addressing pain points in process chemistry.

Emerging applications in proteomics and DNA sequencing reagents further expand the utility of CAS 858842-11-2. Its compatibility with solid-phase synthesis supports automated platforms, answering search trends like "sulfonyl chlorides for combinatorial chemistry." Regulatory databases confirm its compliance with major REACH and FDA guidelines when used as an intermediate, a critical factor for contract manufacturing organizations (CMOs).

In summary, 3-Methoxy-2-methylbenzene-1-sulfonyl chloride represents a multifaceted tool for modern chemists. Its intersection with drug discovery, advanced materials, and sustainable methodologies ensures continued relevance in both academic and industrial settings, validated by persistent search interest and evolving literature citations.

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