Production Method 1

54413-93-3

857599-37-2

Reaction Conditions

1.1 Catalysts: Sulfuric acid ;  rt; rt → reflux; 4 h, reflux; reflux → rt
1.2 Reagents: Sodium carbonate Solvents: Water

Reference

A general method for one-step synthesis of monofluoroiodane(III) reagents using silver difluoride

Ren, Jing; et al, Chinese Chemical Letters, 2022, 33(11), 4834-4837

Production Method 2

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt
1.2 Reagents: Water

Reference

A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

Nakazaki, Atsuo ; et al, Chemistry - An Asian Journal, 2016, 11(22), 3267-3274

Production Method 3

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

2-Iodo-N-isopropyl-5-methoxybenzamide as a highly reactive and environmentally benign catalyst for alcohol oxidation

Yakura, Takayuki; et al, Beilstein Journal of Organic Chemistry, 2018, 14, 971-978

Production Method 4

54413-93-3

857599-37-2

Reaction Conditions

1.1 Catalysts: Dimethylformamide Solvents: Dichloromethane ;  0 °C; 2 h, rt
1.2 Solvents: Methanol ,  Dichloromethane ;  30 min, rt

Reference

Cyclopropane-Fused N-Heterocycles via Aza-Heck-Triggered C(sp3)-H Functionalization Cascades

Jing, Changcheng; et al, Journal of the American Chemical Society, 2022, 144(37), 16749-16754

Production Method 5

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  12 h, reflux; reflux → rt

Reference

2-Iodoxybenzenesulfonic Acid as an Extremely Active Catalyst for the Selective Oxidation of Alcohols to Aldehydes, Ketones, Carboxylic Acids, and Enones with Oxone

Uyanik, Muhammet; et al, Journal of the American Chemical Society, 2009, 131(1), 251-262

Production Method 6

394-31-0

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  0 °C; 5 min, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  0 °C; 1 h, 100 °C; 100 °C → rt; 14 h, rt
1.3 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

2-Iodo-N-isopropyl-5-methoxybenzamide as a highly reactive and environmentally benign catalyst for alcohol oxidation

Yakura, Takayuki; et al, Beilstein Journal of Organic Chemistry, 2018, 14, 971-978

Production Method 7

394-31-0

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  0 °C; 5 min, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  0 °C; 1 h, 100 °C; 100 °C → rt; 14 h, rt
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt
2.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified, rt

Reference

2-Iodo-N-isopropyl-5-methoxybenzamide as a highly reactive and environmentally benign catalyst for alcohol oxidation

Yakura, Takayuki; et al, Beilstein Journal of Organic Chemistry, 2018, 14, 971-978

Production Method 8

394-31-0

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  10 min, < 5 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  15 min, < 5 °C; 3 h, 100 °C; 100 °C → rt; 18 h, rt
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  12 h, rt
2.2 Reagents: Water

Reference

A Divergent Approach to the Diastereoselective Synthesis of 3,3-Disubstituted Oxindoles from Atropisomeric N-Aryl Oxindole Derivatives

Nakazaki, Atsuo ; et al, Chemistry - An Asian Journal, 2016, 11(22), 3267-3274

Production Method 9

54413-93-3

857599-37-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Methanol ;  0 °C; 4 h, 75 °C

Reference

Synthesis of FeIII and FeIV Cyanide Complexes Using Hypervalent Iodine Reagents as Cyano-Transfer One-Electron Oxidants

Souilah, Charafa; et al, Angewandte Chemie, 2022, 61(22),

Production Method 10

54413-93-3

857599-37-2

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  12 h, 80 °C; 80 °C → rt
1.2 Reagents: Potassium carbonate

Reference

2,7-Dinitrophenanthrene-9,10-dione as a photosensitizer for the dehydrogenative lactonization of 2-arylbenzoic acids

Shi, Gaochang; et al, Organic Chemistry Frontiers, 2023, 10(10), 2429-2433

Production Method 11

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ,  Dimethylformamide ;  4 h, rt

Reference

Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum

Murata, Chihiro; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(5), 1428-1433

Production Method 12

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Acetone ;  24 h, rt → reflux

Reference

Direct Carbocyclizations of Benzoic Acids: Catalyst-Controlled Synthesis of Cyclic Ketones and the Development of Tandem aHH (acyl Heck-Heck) Reactions

Miles, Kelsey C.; et al, Chemistry - A European Journal, 2014, 20(36), 11336-11339

Production Method 13

57772-57-3

857599-37-2

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethyl carbonate ;  16 h, reflux

Reference

Rapid access to a pentacyclic library core structure: A microwave assisted approach

Patterson, Stephen; et al, QSAR & Combinatorial Science, 2004, 23(10), 883-890

Production Method 14

2475-80-1

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Sulfuric acid Solvents: Water ;  -5 °C; 30 min, -5 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  -5 °C; 1 - 3 h, rt

Reference

Optimization of a Benzoylpiperidine Class Identifies a Highly Potent and Selective Reversible Monoacylglycerol Lipase (MAGL) Inhibitor

Granchi, Carlotta; et al, Journal of Medicinal Chemistry, 2019, 62(4), 1932-1958

Production Method 15

6705-03-9

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  0 °C; 20 min, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  cooled; 70 °C
1.3 Reagents: Thionyl chloride Solvents: Methanol ;  0 °C; 0 °C → reflux; 2 h, reflux

Reference

A facile synthesis of dibenzopyrroloazepinones as tetracyclic allocolchicinoids - an unusual 1,2-phenyl shift

Wu, Liang; et al, Chemical Communications (Cambridge, 2010, 46(2), 318-320

Production Method 16

54413-93-3

857599-37-2

Reaction Conditions

Reference

Pd-Catalyzed/Iodide-Promoted α-Arylation of Ketones for the Regioselective Synthesis of Isocoumarins

Casnati, Alessandra; et al, Journal of Organic Chemistry, 2017, 82(15), 8296-8303

Production Method 17

394-31-0

857599-37-2

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  30 min, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  0 °C; 20 min, 0 °C; 30 min, 90 °C
2.1 Reagents: Potassium carbonate Solvents: Acetone ,  Dimethylformamide ;  4 h, rt

Reference

Synthesis and SAR of 4-methyl-5-pentylbenzene-1,3-diol (MPBD), produced by Dictyostelium discoideum

Murata, Chihiro; et al, Bioorganic & Medicinal Chemistry Letters, 2016, 26(5), 1428-1433

Methyl 2-iodo-5-methoxybenzoate Raw materials

• 5-Hydroxyanthranilic acid
• 2-Amino-5-methoxybenzoic acid
• Methyl 2-amino-5-methoxybenzoate
• 2-Iodo-5-methoxybenzoic acid
• 5-Hydroxy-2-iodobenzoic acid

Methyl 2-iodo-5-methoxybenzoate Preparation Products

• Methyl 2-iodo-5-methoxybenzoate (857599-37-2)

• 1. An automated in-chip-catalytic–spectrophotometric method for determination of copper(ii) using a multisyringe flow injection analysis-multipumping flow system?
  Camelia Henríquez,Edwin Palacio,Víctor Cerdà Anal. Methods, 2014,6, 8494-8504
• 2. Agonist responses of (R)- and (S)-3-fluoro-γ-aminobutyric acids suggest an enantiomeric fold for GABA binding to GABAC receptors?
  Izumi Yamamoto,Gildas P. Deniau,Navnath Gavande,Mary Chebib,Graham A. R. Johnston,David O'Hagan Chem. Commun., 2011,47, 7956-7958
• 3. Achieving high thermal stability of different rare-earth ions in a single matrix host via the manipulation of the local structure by a solid solution?
  Xiuxia Yang,Lei Zhao,Zhichao Liu,Shuyu Tian,Hao Zhang,Xuhui Xu,Jianbei Qiu,Xue Yu Phys. Chem. Chem. Phys., 2020,22, 16294-16300
• 4. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 5. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068

• 99665-70-0(Ethyl 5-hydroxy-2-iodobenzoate)
• 358672-64-7(Methyl 5-Hydroxy-2-iodobenzoate)
• 497937-01-6(Benzoic acid, 2,4,6-triiodo-3-methoxy-, methyl ester)
• 104807-65-0(Ethyl 2-iodo-5-methoxybenzoate)
• 79780-07-7(Phenyl 2-iodobenzoate)
• 35387-95-2(&nbsp;)
• 54413-93-3(2-Iodo-5-methoxybenzoic acid)
• 499157-40-3(Benzoic acid, 2-iodo-4-(phenoxymethyl)-, methyl ester)
• 22621-40-5(Benzoic acid,2-(acetyloxy)-5-iodo-, methyl ester)
• 173043-61-3(Methyl 2-iodo-4,5-dimethoxybenzoate)