Production Method 1

2973-80-0

85604-06-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  2 h, 80 °C

Reference

Total Synthesis of Bulbophylol-B

Lin, Jinshun; et al, Journal of Natural Products, 2008, 71(11), 1938-1941

Production Method 2

1700-37-4

85604-06-4

Reaction Conditions

1.1 Reagents: Sodium acetate ,  Bromine Solvents: Dichloromethane ;  45 min, cooled; 5 h; 0 °C

Reference

Total Synthesis of (+)-Korupensamine B via an Atropselective Intermolecular Biaryl Coupling

Huang, Shenlin; et al, Journal of the American Chemical Society, 2010, 132(40), 14021-14023

Production Method 3

100-83-4

85604-06-4

Reaction Conditions

1.1 Reagents: Bromine Solvents: Carbon tetrachloride ;  15 min, 25 °C; 2 h, 25 °C
1.2 Reagents: Water Solvents: Dichloromethane
2.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  2 h, 80 °C

Reference

Total Synthesis of Bulbophylol-B

Lin, Jinshun; et al, Journal of Natural Products, 2008, 71(11), 1938-1941

Production Method 4

2973-80-0

85604-06-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt
1.2 Reagents: Water ;  rt

Reference

1,4-Palladium Shift/C(sp3)-H Activation Strategy for the Remote Construction of Five-Membered Rings

Rocaboy, Ronan; et al, Organic Letters, 2019, 21(5), 1434-1437

Production Method 5

2973-80-0

85604-06-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  2 h, rt

Reference

Identification of vimentin binding to the derivative of saurolactam with antiresorptive activity by using its chemical affinity probe

Kim, Myung Hee; et al, Bulletin of the Korean Chemical Society, 2010, 31(7), 2047-2050

Production Method 6

1084897-39-1

85604-06-4

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Catalysts: 1,10-Phenanthroline ,  Cuprous iodide Solvents: Toluene ;  7 - 48 h, 80 °C; 80 °C → rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Simple, Copper(I)-Catalyzed Oxidation of Benzylic/Allylic Alcohols to Carbonyl Compounds: Synthesis of Functionalized Cinnamates in One Pot

Reddy, Alavala Gopi Krishna; et al, Synthetic Communications, 2014, 44(14), 2076-2087

Production Method 7

100-83-4

85604-06-4

Reaction Conditions

1.1 Reagents: Bromine Solvents: Chloroform
1.2 Reagents: Sodium hydride Solvents: Dimethylformamide ,  Tetrahydrofuran
1.3 Solvents: Dimethylformamide ,  Tetrahydrofuran

Reference

Molecular Clefts. 4. An Approach to Structural Analogs of Echinomycin: Synthesis of a New Class of Synthetic Molecular Tweezers

Harmata, Michael; et al, Journal of the American Chemical Society, 1994, 116(18), 8392-3

Production Method 8

100-83-4

85604-06-4

Reaction Conditions

1.1 Reagents: Bromine Solvents: Dichloromethane ;  18 h, rt
1.2 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  4 h, rt

Reference

High-Throughput Crystallography Reveals Boron-Containing Inhibitors of a Penicillin-Binding Protein with Di- and Tricovalent Binding Modes

Newman, Hector; et al, Journal of Medicinal Chemistry, 2021, 64(15), 11379-11394

Production Method 9

100-83-4

85604-06-4

Reaction Conditions

1.1 Reagents: Potassium carbonate Catalysts: 18-Crown-6 Solvents: Acetone ;  overnight, rt
2.1 Reagents: Sodium acetate ,  Bromine Solvents: Dichloromethane ;  45 min, cooled; 5 h; 0 °C

Reference

Total Synthesis of (+)-Korupensamine B via an Atropselective Intermolecular Biaryl Coupling

Huang, Shenlin; et al, Journal of the American Chemical Society, 2010, 132(40), 14021-14023

Production Method 10

7507-86-0

85604-06-4

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Acetic acid ,  Water ;  3 h, 100 °C
1.2 Reagents: Sodium hydroxide Solvents: Water ;  basified
1.3 Reagents: Hydrochloric acid Solvents: Water ;  pH 1
2.1 Reagents: Potassium carbonate

Reference

Binding and Preliminary Evaluation of 5-Hydroxy- and 10-Hydroxy-2,3,12,12a-tetrahydro-1H-[1]benzoxepino[2,3,4-ij]isoquinolines as Dopamine Receptor Ligands

Claudi, Francesco; et al, Journal of Medicinal Chemistry, 2000, 43(4), 599-608

5-(Benzyloxy)-2-bromobenzaldehyde Raw materials

• 3-Hydroxybenzaldehyde
• (5-(Benzyloxy)-2-bromophenyl)methanol
• 3-(benzyloxy)benzaldehyde
• 2-Bromo-5-methoxybenzaldehyde
• 2-Bromo-5-hydroxybenzaldehyde

5-(Benzyloxy)-2-bromobenzaldehyde Preparation Products

• 5-(Benzyloxy)-2-bromobenzaldehyde (85604-06-4)

• 1. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592
• 2. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 3. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
• 4. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

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