• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 3. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 4. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 5. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines Pyrrolopyridines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyridines

Recent Advances in the Study of 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one (CAS: 853577-50-1)

4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one (CAS: 853577-50-1) is a heterocyclic compound that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its potential applications in drug discovery and development. This research brief aims to provide an overview of the latest studies and findings related to this compound, focusing on its synthesis, biological activity, and therapeutic potential.

Recent literature highlights the importance of 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one as a key intermediate in the synthesis of various pharmacologically active molecules. Studies have demonstrated its utility in the development of kinase inhibitors, which are critical for targeting signaling pathways involved in cancer and inflammatory diseases. The compound's unique structure allows for selective modulation of enzyme activity, making it a valuable scaffold for drug design.

One of the most notable advancements is the optimization of synthetic routes for 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one, which has improved yield and purity. Researchers have employed modern techniques such as microwave-assisted synthesis and flow chemistry to enhance efficiency and reduce environmental impact. These innovations are crucial for scaling up production and facilitating further pharmacological evaluations.

In terms of biological activity, recent in vitro and in vivo studies have explored the compound's potential as an anti-inflammatory and anti-cancer agent. Preliminary results indicate that derivatives of 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one exhibit promising inhibitory effects on specific kinases, such as JAK and PI3K, which are implicated in various pathological conditions. These findings underscore the compound's versatility and potential for therapeutic applications.

Furthermore, computational modeling and structure-activity relationship (SAR) studies have provided insights into the molecular interactions of 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one with its biological targets. These studies have identified key structural features that contribute to its activity and selectivity, paving the way for the design of more potent and specific analogs.

Despite these promising developments, challenges remain in the clinical translation of 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one-based therapeutics. Issues such as bioavailability, metabolic stability, and potential off-target effects need to be addressed through further research. Collaborative efforts between chemists, biologists, and pharmacologists will be essential to overcome these hurdles and realize the full potential of this compound.

In conclusion, 4-Chloro-1h-pyrrolo3,4-cpyridin-3(2H)-one (CAS: 853577-50-1) represents a promising scaffold in medicinal chemistry with diverse applications. Continued research into its synthesis, biological activity, and therapeutic potential will likely yield significant advancements in drug discovery and development. This brief serves as a foundation for further exploration and discussion within the scientific community.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)