Production Method 1

29270-30-2

85259-19-4

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Water ;  5 h, reflux

Reference

Synthesis of racemic Clopidogrel

Xu, Ke-hui; Liu, Pei-pei; Lin, Fei-fei; Pan, Fan-bing; Guo, Hai-chang, Zhejiang Huagong, 2010, 41(5), 6-7

Production Method 2

57486-68-7

85259-19-4

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Catalysts: Benzoyl peroxide Solvents: 1,2-Dichloroethane ;  12 h, reflux

Reference

Regio- and Chemoselective C-H Chlorination/Bromination of Electron-Deficient Arenes by Weak Coordination and Study of Relative Directing-Group Abilities

Sun, Xiuyun; Shan, Gang; Sun, Yonghui; Rao, Yu, Angewandte Chemie, 2013, 52(16), 4440-4444

Production Method 3

138647-05-9

85259-19-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Methanol ;  30 min, rt; rt → 50 °C; 30 min, 50 °C

Reference

Synthesis of intermediates of Clopidogrel

Zhang, Qing-shan; Zou, Jiang, Jingxi Huagong, 2004, 21(3), 195-196

Production Method 4

29270-30-2

85259-19-4

Reaction Conditions

1.1 Solvents: Methanol ;  rt; 3 h, reflux

Reference

Synthesis and Characterization of Impurity B of S-(+)-Clopidogrel Bisulfate: An Antiplatelet

Reddy, K. Tatendra; Kumar, K. Suneel; Omprakash, G.; Dubey, P. K., Synthetic Communications, 2013, 43(10), 1387-1396

Production Method 5

138647-05-9

85259-19-4

Reaction Conditions

1.1 Reagents: Triethylamine Solvents: Methanol ;  2 h, 20 - 25 °C

Reference

Improved method for synthesis of Clopidogrel bisulfate

Liu, Jie; Wang, Wen-feng; Yang, Yan; Chi, Xiao-wei, Huaxue Shiji, 2009, 31(8), 664-666

Production Method 6

156276-21-0

85259-19-4

Reaction Conditions

1.1 Reagents: Phosphorus tribromide Solvents: Chloroform ;  4 d, rt

Reference

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

Eilertsen, Monica; Allin, Steve M.; Pearson, Russell J., Bioorganic & Medicinal Chemistry Letters, 2018, 28(6), 1106-1110

Methyl a-Bromo-2-chlorophenylacetate Raw materials

• 2-Bromo-2-(2-chlorophenyl)acetic Acid
• Benzeneacetyl chloride, α-bromo-2-chloro-
• Methyl 2-chlorophenylacetate
• methyl 2-(2-chlorophenyl)-2-hydroxyacetate

Methyl a-Bromo-2-chlorophenylacetate Preparation Products

• Methyl a-Bromo-2-chlorophenylacetate (85259-19-4)

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• 5. Evolutionary de novo design of phenothiazine derivatives for dye-sensitized solar cells?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Chlorobenzenes
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 29270-30-2(2-Bromo-2-(2-chlorophenyl)acetic Acid)
• 24091-92-7(Methyl 2-Bromo-2-(4-chlorophenyl)acetate)
• 3381-73-5(2-Bromo-2-(4-chlorophenyl)acetic acid)
• 41204-08-4(Benzeneacetic acid, a-bromo-3,4-dichloro-, ethyl ester)
• 35282-98-5(Benzenepropanoic acid, a,b-dibromo-2-chloro-, ethyl ester)
• 622835-93-2(Methyl (2R)-2-bromo-2-(2-chlorophenyl)acetate)
• 103807-49-4(Isopropyl 2-bromo-2-(4-chlorophenyl)acetate)
• 141109-25-3(2-Bromo-2-(2-chlorophenyl)acetic acid)
• 41024-33-3(Ethyl 2-Bromo-2-(3-chlorophenyl)acetate)
• 41022-55-3(Benzeneacetic acid, a-bromo-2,4-dichloro-, ethyl ester)