Production Method 1

852475-68-4

852475-26-4

Reaction Conditions

1.1 Reagents: Triethylamine ,  Ethyl chloroformate Solvents: Tetrahydrofuran ;  10 min, 0 °C
1.2 Reagents: O-(1-Methoxy-1-methylethyl)hydroxylamine ;  15 min, 0 °C
1.3 Reagents: Amberlyst 15 Solvents: Methanol ;  1 h, 45 °C

Reference

Class II (IIa)-Selective Histone Deacetylase Inhibitors. 1. Synthesis and Biological Evaluation of Novel (Aryloxopropenyl)pyrrolyl Hydroxyamides

Mai, Antonello; Massa, Silvio; Pezzi, Riccardo; Simeoni, Silvia; Rotili, Dante; et al, Journal of Medicinal Chemistry, 2005, 48(9), 3344-3353

Production Method 2

852475-26-4

Reaction Conditions

1.1 Reagents: p-Toluenesulfonic acid monohydrate Solvents: Methanol ;  1 h, 21 °C

Reference

Improved Synthesis and Structural Reassignment of MC1568: A Class IIa Selective HDAC Inhibitor

Fleming, Cassandra L.; Ashton, Trent D.; Gaur, Vidhi; McGee, Sean L.; Pfeffer, Frederick M., Journal of Medicinal Chemistry, 2014, 57(3), 1132-1135

Production Method 3

2244576-17-6

852475-26-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide ,  Hydroxyamine hydrochloride Solvents: Ethanol ;  1 h, 0 °C

Reference

MC1568 inhibits HDAC6/8 activity and influenza A virus replication in lung epithelial cells: role of Hsp90 acetylation

Panella, Simona; Marcocci, Maria Elena; Celestino, Ignacio; Valente, Sergio; Zwergel, Clemens; et al, Future Medicinal Chemistry, 2016, 8(17), 2017-2031

MC1568 Raw materials

• 2-Propenoic acid,3-[4-[3-(3-fluorophenyl)-3-oxo-1-propenyl]-1-methyl-1H-pyrrol-2-yl]-
• Ethyl (2E)-3-[5-[(1E)-3-(3-fluorophenyl)-3-oxo-1-propen-1-yl]-1-methyl-1H-pyrrol-2-yl]-2-propenoate

MC1568 Preparation Products

• MC1568 (852475-26-4)

• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Other Chemical additives Functional Additives
• Pharmaceutical and Biochemical Products Medical Disease Classifications

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)