Production Method 1

852203-16-8

852203-17-9

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride Solvents: 1,4-Dioxane ;  2 min, rt; 15 min, 120 °C

Reference

Microwave-assisted multistep synthesis of functionalized 4-arylquinolin-2(1H)-ones using palladium-catalyzed cross-coupling chemistry

Glasnov, Toma N.; Stadlbauer, Wolfgang; Kappe, C. Oliver, Journal of Organic Chemistry, 2005, 70(10), 3864-3870

Production Method 2

878133-02-9

852203-17-9

Reaction Conditions

1.1 Reagents: Acetonitrile Solvents: Acetonitrile ;  rt; 12 h, 150 °C
1.2 Reagents: Water ;  30 min, rt

Reference

Acetonitrile-mediated synthesis of 2,4-dichloroquinoline from 2-ethynylaniline and 2,4-dichloroquinazoline from anthranilonitrile

Lee, Jae Hak; Lee, Byoung Se; Shin, Hyunik; Nam, Do Hyun; Chi, Dae Yoon, Synlett, 2006, (1), 65-68

2,4-Dichloro-6-(trifluoromethyl)quinoline Raw materials

• 2(1H)-Quinolinone, 4-hydroxy-6-(trifluoromethyl)-
• 2-ethynyl-4-(trifluoromethyl)aniline

2,4-Dichloro-6-(trifluoromethyl)quinoline Preparation Products

• 2,4-Dichloro-6-(trifluoromethyl)quinoline (852203-17-9)

• 1. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745
• 2. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 3. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Chloroquinolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Haloquinolines Chloroquinolines

• 1196154-02-5(1-chloro-7-(trifluoromethyl)isoquinoline)
• 1196152-92-7(1-chloro-6-(trifluoromethyl)isoquinoline)
• 920494-31-1(2-chloro-8-(trifluoromethyl)quinoline)
• 2806-29-3(2-Chloro-4-(trifluoromethyl)quinoline)
• 49713-56-6(4-Chloro-6-(trifluoromethyl)quinoline)
• 346-55-4(4-Chloro-7-(trifluoromethyl)quinoline)
• 874813-51-1(Acridine, 6,9-dichloro-2-(trifluoromethyl)-)
• 83183-56-6(2-chloro-7-(trifluoromethyl)quinoline)
• 78060-56-7(2-chloro-6-(trifluoromethyl)quinoline)
• 435278-04-9(1-Chloro-5-(trifluoromethyl)isoquinoline)