• 1. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 2. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 4. Examination of ammonia–poly(pyrrole) interactions by piezoelectric and conductivity measurements
  Analyst, 1991,116, 1125-1130
• 5. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890

Comprehensive Overview of 3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde (CAS No. 852180-68-8)

3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde (CAS No. 852180-68-8) is a specialized organic compound that has garnered significant attention in pharmaceutical and agrochemical research. This compound features a unique 1,2,4-oxadiazole ring, a heterocyclic moiety known for its versatility in drug design and material science. The presence of both the oxadiazole and benzaldehyde functional groups makes it a valuable intermediate for synthesizing bioactive molecules, including potential antiviral agents and enzyme inhibitors.

In recent years, the demand for heterocyclic compounds like 3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde has surged due to their applications in medicinal chemistry and crop protection. Researchers are particularly interested in its role as a scaffold for drug discovery, especially in targeting inflammatory diseases and metabolic disorders. Its CAS No. 852180-68-8 is frequently searched in scientific databases, reflecting its relevance in high-throughput screening and structure-activity relationship (SAR) studies.

The compound’s benzaldehyde moiety allows for further derivatization, enabling the creation of novel Schiff bases or hydrazone derivatives, which are pivotal in developing antimicrobial and anticancer agents. Additionally, the 5-methyl-1,2,4-oxadiazole ring enhances its stability and bioavailability, making it a preferred choice for lead optimization in preclinical studies. These attributes align with current trends in green chemistry, where researchers prioritize sustainable synthesis methods for such intermediates.

From an industrial perspective, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde is often discussed in the context of patented formulations and intellectual property in the pharmaceutical sector. Its CAS registry number (852180-68-8) is a critical identifier for regulatory compliance and material safety data sheets (MSDS). Moreover, its potential as a fluorescence probe or sensor material has sparked interest in analytical chemistry and diagnostic applications.

In summary, 3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde represents a multifaceted compound with broad applicability across life sciences and industrial R&D. Its structural features and synthetic accessibility position it as a key player in advancing precision medicine and agrochemical innovation. As research continues, this compound is likely to remain a focal point for academic publications and commercial exploitation.

• 1198-98-7(5-Methyl-3-phenyl-1,2,4-oxadiazole)
• 87944-75-0(1,2,4-Oxadiazole, 5-methyl-3-(3-methylphenyl)-)
• 273727-50-7(3-(3-Methyl-1,2,4-oxadiazol-5-yl)benzaldehyde)
• 222541-76-6(4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoyl Chloride)
• 264264-32-6(3-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid)
• 95124-68-8(4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzoic acid)
• 253273-90-4(3-3-(Bromomethyl)Phenyl-5-Methyl-1,2,4-Oxadiazole)
• 852180-60-0(4-(5-Methyl-1,2,4-oxadiazol-3-yl)benzaldehyde)
• 256956-42-0(3-4-(Bromomethyl)phenyl-5-methyl-1,2,4-oxadiazole)
• 89612-19-1(1,2,4-Oxadiazole, 3-(2,6-dimethylphenyl)-5-methyl-)