Cas no 85148-26-1 (3-Chloro-5-(trifluoromethyl)pyridine)

3-Chloro-5-(trifluoromethyl)pyridine is a halogenated pyridine derivative featuring both chloro and trifluoromethyl functional groups. This compound is widely utilized as a key intermediate in pharmaceutical and agrochemical synthesis due to its reactive sites, which facilitate further functionalization. The presence of the trifluoromethyl group enhances lipophilicity and metabolic stability, making it valuable in the development of bioactive molecules. Its chloro substituent allows for selective cross-coupling reactions, enabling precise structural modifications. The compound exhibits high purity and stability under standard storage conditions, ensuring reliable performance in synthetic applications. Its versatility and reactivity make it a preferred building block in medicinal chemistry and crop protection research.
3-Chloro-5-(trifluoromethyl)pyridine structure
85148-26-1 structure
Product Name:3-Chloro-5-(trifluoromethyl)pyridine
CAS No:85148-26-1
MF:C6H3ClF3N
MW:181.542930841446
MDL:MFCD00042227
CID:60844
PubChem ID:253662595
Update Time:2025-05-28

3-Chloro-5-(trifluoromethyl)pyridine Chemical and Physical Properties

Names and Identifiers

    • 3-Chloro-5-(trifluoromethyl)pyridine
    • 3-chloro-5-trifluoromethylpyridine
    • 3-chloro-5-trifluoromethyl-pyridine
    • 3-Trifluoromethyl-5-chloropyridine
    • 3-Chloro-5-(trifluoromethyl)pyridine (ACI)
    • SCHEMBL876019
    • 85148-26-1
    • PS-6449
    • DTXSID30371538
    • AKOS005063769
    • DB-003925
    • MFCD00042227
    • Q-101483
    • 3-Chloro-5-(trifluoromethyl)pyridine, 97%
    • EN300-114758
    • CS-W002205
    • Pyridine, 3-chloro-5-(trifluoromethyl)-
    • BBL101564
    • 3-Chloro-5-(trifluoromethyl)pyridine-carbonitrile
    • C2951
    • PB18435
    • J-512259
    • STL555360
    • AC-23348
    • MDL： MFCD00042227
    • Inchi： 1S/C6H3ClF3N/c7-5-1-4(2-11-3-5)6(8,9)10/h1-3H
    • InChI Key： OMRCXTBFBBWTDL-UHFFFAOYSA-N
    • SMILES： FC(C1C=C(Cl)C=NC=1)(F)F

Computed Properties

  • Exact Mass: 180.99100
  • Monoisotopic Mass: 180.991
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 11
  • Rotatable Bond Count: 1
  • Complexity: 136
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2.4
  • Topological Polar Surface Area: 12.9A^2

Experimental Properties

  • Color/Form: No data available
  • Density: 1.389
  • Melting Point: 23-27?°C
  • Boiling Point: 133-138?°C
  • Flash Point: Fahrenheit: 129.2 ° f
    Celsius: 54 ° c
  • Refractive Index: 1.4460 to 1.4500
  • PSA: 12.89000
  • LogP: 2.75380

3-Chloro-5-(trifluoromethyl)pyridine Security Information

  • Symbol: GHS06
  • Prompt：dangerous
  • Signal Word：Danger
  • Hazard Statement： H301,H315,H319,H335
  • Warning Statement： P261,P301+P310,P305+P351+P338
  • Hazardous Material transportation number：UN 2811 6.1 / PGIII
  • WGK Germany：3
  • Hazard Category Code： 25-36/37/38
  • Safety Instruction： S26-S36/37-S36
  • Hazardous Material Identification： T
  • HazardClass：6.1
  • PackingGroup：III
  • Risk Phrases：R20/21/22
  • Storage Condition：Store at 4°C,-4At ℃Store…Better

3-Chloro-5-(trifluoromethyl)pyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

3-Chloro-5-(trifluoromethyl)pyridine Pricemore >>

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3-Chloro-5-(trifluoromethyl)pyridine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: 1,8-Diazabicyclo[5.4.0]undec-7-ene Solvents: Acetonitrile ;  24 h, < 30 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  24 h, 60 °C
1.3 Reagents: Sodium carbonate Solvents: Water ;  basified
Reference
Radical and ionic meta-C-H functionalization of pyridines, quinolines, and isoquinolines
Cao, Hui ; Cheng, Qiang ; Studer, Armido, Science (Washington, 2022, 378(6621), 779-785

Production Method 2

Reaction Conditions
1.1 Reagents: Indium Solvents: 1-Butyl-3-methylimidazolium bromide ;  14 h, 95 °C
Reference
Efficient indium-mediated dehalogenation of aromatics in ionic liquid media
Canete, Alvaro F.; Salas, Cristian O.; Zacconi, Flavia C., Molecules, 2013, 18, 398-407

3-Chloro-5-(trifluoromethyl)pyridine Raw materials

3-Chloro-5-(trifluoromethyl)pyridine Preparation Products

3-Chloro-5-(trifluoromethyl)pyridine Suppliers

Suzhou Senfeida Chemical Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:85148-26-1)3-Chloro-5-(trifluoromethyl)pyridine
Order Number:sfd10252
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:35
Price ($):discuss personally
Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:85148-26-1)3-Chloro-5-(trifluoromethyl)pyridine
Order Number:A10216
Stock Status:in Stock
Quantity:250.0g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 15:26
Price ($):215.0
Tiancheng Chemical (Jiangsu) Co., Ltd
Gold Member
Audited Supplier Audited Supplier
(CAS:85148-26-1)3-氯-5-三氟甲基吡啶
Order Number:LE1690291
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 12:33
Price ($):discuss personally

3-Chloro-5-(trifluoromethyl)pyridine Related Literature

85148-26-1 (3-Chloro-5-(trifluoromethyl)pyridine) Related Products

Recommended suppliers
Suzhou Senfeida Chemical Co., Ltd
(CAS:85148-26-1)3-Chloro-5-(trifluoromethyl)pyridine
sfd10252
Purity:99.9%
Quantity:200kg
Price ($):Inquiry
Email
Amadis Chemical Company Limited
(CAS:85148-26-1)3-Chloro-5-(trifluoromethyl)pyridine
A10216
Purity:99%
Quantity:250.0g
Price ($):215.0
Email