Production Method 1

908600-92-0

851368-08-6

Reaction Conditions

1.1 Reagents: Hydrogen bromide Solvents: Ethanol ,  Water ;  1 h, rt
1.2 Reagents: Hydrogen bromide Solvents: Water ;  10 min, rt → 60 °C; 60 °C → 0 °C
1.3 Reagents: Sodium nitrite Solvents: Water ;  < 5 °C; 15 min, 0 °C
1.4 Reagents: Copper ;  1 h, 0 °C → 80 °C; 80 °C → rt

Reference

Palladium-catalyzed aryl amination- heck cyclization cascade: a one-flask approach to 3-substituted indoles

Jensen, Thomas; Pedersen, Henrik; Bang-Andersen, Benny; Madsen, Robert; Joergensen, Morten, Angewandte Chemie, 2008, 47(5), 888-890

Production Method 2

1121-86-4

851368-08-6

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ,  Hexane ;  2 h, -75 °C
1.2 Reagents: 1,2-Dibromo-1,1,2,2-tetrafluoroethane

Reference

Promoting or preventing haloaryllithium isomerizations: differential basicities and solvent effects as the crucial variables

Heiss, Christophe; Rausis, Thierry; Schlosser, Manfred, Synthesis, 2005, (4), 617-621

Production Method 3

111721-75-6

851368-08-6

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water ;  30 min, 0 °C
1.2 Reagents: Potassium iodide Solvents: Water ;  3 h, 60 °C
1.3 Reagents: Sodium thiosulfate Solvents: Water

Reference

Enantioselective Synthesis of 6/5-Spirosilafluorenes by Asymmetric Ring Expansion of 4/5-Spirosilafluorenes with Alkynes

Chen, Hua; Zhang, Haixia; Du, Huimin; Kuang, Yuzhong; Pang, Qinjiao; et al, Organic Letters, 2023, 25(9), 1558-1563

2-bromo-1-fluoro-3-iodo-benzene Raw materials

• 1-Fluoro-3-iodobenzene
• (2-fluoro-6-iodophenyl)carbaMic acid tert-butyl ester
• 2-bromo-3-fluoroaniline

2-bromo-1-fluoro-3-iodo-benzene Preparation Products

• 2-bromo-1-fluoro-3-iodo-benzene (851368-08-6)

• 1. An astrophysically-relevant mechanism for amino acid enantiomer enrichment
  Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
• 2. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 3. An atom-economical protocol for direct conversion of Baylis–Hillman alcohols to β-chloro aldehydes in water?
  Raktani Bikshapathi,Sai Prathima Parvathaneni,Vaidya Jayathirtha Rao Green Chem., 2017,19, 4446-4450
• 4. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 5. An amide probe as a selective Al3+ and Fe3+ sensor inside the HeLa and a549 cell lines: Pictet–Spengler reaction for the rapid detection of tryptophan amino acid?
  Bidyut Kumar Kundu,Rinky Singh,Ritudhwaj Tiwari,Debasis Nayak New J. Chem., 2019,43, 4867-4877

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Iodobenzenes

• 63266-28-4(Benzene, 1,2,4,5-tetrabromo-3-fluoro-6-iodo-)
• 1263376-83-5(1,4-dibromo-2-fluoro-5-iodobenzene)
• 1000578-13-1(2,4-Dibromo-5-fluoroiodobenzene)
• 811842-30-5(2-Bromo-1-fluoro-4-iodobenzene)
• 202865-72-3(1-Bromo-4-fluoro-2-iodobenzene)
• 136434-77-0(1-Bromo-2-fluoro-4-iodobenzene)
• 202865-73-4(2-Bromo-4-fluoro-1-iodobenzene)
• 155906-10-8(2-Bromo-1,3-difluoro-5-iodobenzene)
• 1000577-89-8(1,3-Dibromo-2,5-difluoro-4-iodobenzene)
• 1000577-95-6(1,3-Dibromo-2,4-difluoro-6-iodobenzene)