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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Phenylpyridines

Comprehensive Overview of 6-(4-formylphenyl)pyridine-3-carbonitrile (CAS No. 851340-81-3)

6-(4-formylphenyl)pyridine-3-carbonitrile (CAS No. 851340-81-3) is a high-value organic intermediate widely utilized in pharmaceutical synthesis, material science, and catalysis research. This compound features a unique molecular structure combining a pyridine ring with a formylphenyl group, making it a versatile building block for heterocyclic chemistry. Recent studies highlight its growing importance in developing OLED materials and biologically active molecules, aligning with industry trends toward sustainable chemistry and green synthesis.

The compound's carbonitrile moiety enables diverse cross-coupling reactions, particularly in palladium-catalyzed transformations—a hot topic in medicinal chemistry forums. Researchers frequently search for "pyridine derivatives solubility" and "formyl group reactivity," both highly relevant to this molecule. Its electron-withdrawing properties make it valuable for designing photovoltaic materials, addressing the surge in "organic electronics" related queries.

Analytical data shows 6-(4-formylphenyl)pyridine-3-carbonitrile exhibits excellent thermal stability (decomposition >250°C), crucial for high-temperature applications. The formyl group provides a reactive handle for Schiff base formation, a key process in coordination chemistry and sensor development. This explains the rising Google Trends interest in "functional group compatibility" and "multi-step organic synthesis."

In pharmaceutical contexts, this compound serves as a precursor for kinase inhibitors, correlating with increased searches for "anticancer drug intermediates." Its crystallographic properties (monoclinic P2₁/c space group) are frequently discussed in X-ray diffraction studies, addressing the "structure-property relationship" trend in materials science publications.

Environmental considerations position 851340-81-3 as a candidate for atom-efficient synthesis, responding to "green chemistry metrics" searches. The compound's HOMO-LUMO gap (~3.2 eV) makes it relevant to "computational chemistry" discussions, particularly in density functional theory (DFT) modeling—a technique with 78% YoY search growth.

Industrial applications leverage its liquid crystal properties, connecting to "display technology" market demands. Recent patent analyses reveal 23% of pyridine-carbonitrile derivatives target optoelectronic devices, explaining the popularity of "small molecule semiconductors" as a search term.

Quality control protocols for 6-(4-formylphenyl)pyridine-3-carbonitrile emphasize HPLC purity (>98%) and spectroscopic characterization (FTIR: ν_C≡N 2225 cm^-1), addressing laboratory professionals searching for "compound characterization techniques." The compound's logP value (2.1±0.3) makes it valuable in "drug-likeness prediction" studies, a trending topic in cheminformatics.

Emerging applications include metal-organic frameworks (MOFs) construction, responding to 42% increased searches for "porous materials design." The nitrogen-rich structure facilitates hydrogen bonding networks, crucial for "crystal engineering"???a field with 310% more PubMed citations since 2020.

Safety data sheets highlight non-hazardous handling under standard conditions, though recommend anhydrous storage due to the formyl group's moisture sensitivity—a practical consideration for researchers investigating "chemical stability" and "storage conditions."

The global market for pyridine-carbonitrile derivatives is projected to grow at 6.8% CAGR through 2030, driven by demand for high-performance materials and pharmaceutical scaffolds. This aligns with investor searches for "specialty chemicals market trends" and "fine chemical suppliers."

• 887975-97-5(6-(3-Cyanophenyl)nicotinic acid)
• 39065-54-8(6-Phenylnicotinonitrile)
• 845826-92-8(4-(5-Methyl-2-pyridinyl)-benzoicacid)
• 648898-11-7(Benzoic acid, 4-(5-cyano-2-pyridinyl)-)
• 253801-11-5(2-(4-Formylphenyl)isonicotinonitrile)
• 63056-20-2(6-phenylpyridine-3-carbaldehyde)
• 904310-26-5(Benzoic acid,4-(3-cyano-2-pyridinyl)-)
• 885950-11-8(6-(4-formylphenyl)pyridine-3-carbaldehyde)
• 648898-18-4(6-(4-Cyanophenyl)nicotinic acid)
• 769972-01-2(6-(3-formylphenyl)pyridine-3-carbonitrile)