Cas no 85118-27-0 (Citalopram hydrochloride)

Citalopram hydrochloride is a selective serotonin reuptake inhibitor (SSRI) widely used in the treatment of major depressive disorder and other mood-related conditions. Its chemical structure, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride, ensures high specificity for serotonin transporters, minimizing interactions with other neurotransmitter systems. The compound exhibits favorable pharmacokinetics, including good oral bioavailability and linear dose-response characteristics. Its hydrochloride salt form enhances stability and solubility, facilitating consistent formulation. Citalopram hydrochloride is recognized for its well-characterized metabolic pathway, primarily mediated by CYP3A4 and CYP2C19, allowing predictable drug interactions. The substance meets pharmacopeial standards (e.g., USP, Ph. Eur.) for purity and potency, making it a reliable active pharmaceutical ingredient for antidepressant medications.
Citalopram hydrochloride structure
Citalopram hydrochloride structure
Product Name:Citalopram hydrochloride
CAS No:85118-27-0
MF:C20H22ClFN2O
MW:360.852887630463
CID:60840
PubChem ID:3020376
Update Time:2025-11-02

Citalopram hydrochloride Chemical and Physical Properties

Names and Identifiers

    • Citalopram hydrochloride
    • 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrochloride
    • 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile,hydrochloride
    • EINECS 285-680-9
    • UNII-4DY48G26JY
    • 5-Isobenzofurancarbonitrile, 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-, monohydrochloride (9CI)
    • (±)-Citalopram hydrochloride
    • 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile monohydrochloride
    • 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrochloride
    • SCHEMBL1515377
    • Citalopram hydrochloride; (1RS)-1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile hydrochloride
    • 5-ISOBENZOFURANCARBONITRILE, 1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-, MONOHYDROCHLORIDE
    • Q27259466
    • 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-3H-2-benzofuran-5-carbonitrile;hydrochloride
    • D07705
    • 5-ISOBENZOFURANCARBONITRILE, 1-(3-(DIMETHYLAMINO)PROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDRO-, HYDROCHLORIDE (1:1)
    • CITALOPRAM HYDROCHLORIDE [WHO-DD]
    • FXSXPIKCGLXHAW-UHFFFAOYSA-N
    • 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile--hydrogen chloride (1/1)
    • (+/-)-CITALOPRAM HYDROCHLORIDE
    • 4DY48G26JY
    • CITALOPRAM HYDROCHLORIDE [EP MONOGRAPH]
    • NS00093185
    • CITALOPRAM HYDROCHLORIDE [MART.]
    • Seropram (TN)
    • CITALOPRAM HCL
    • 1-(3-DIMETHYLAMINOPROPYL)-1-(4-FLUOROPHENYL)-1,3-DIHYDROISOBENZOFURAN-5-CARBONITRILE HYDROCHLORIDE
    • CITALOPRAM HYDROCHLORIDE (MART.)
    • 85118-27-0
    • CITALOPRAM HYDROCHLORIDE (EP MONOGRAPH)
    • 1-(3-(Dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile monohydrochloride
    • DTXSID101005517
    • Inchi: 1S/C20H21FN2O.ClH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H
    • InChI Key: FXSXPIKCGLXHAW-UHFFFAOYSA-N
    • SMILES: Cl.N#CC1C=C2COC(C2=CC=1)(CCCN(C)C)C1C=CC(F)=CC=1

Computed Properties

  • Exact Mass: 360.14000
  • Monoisotopic Mass: 360.14
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 25
  • Rotatable Bond Count: 5
  • Complexity: 466
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 1
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 36.3A^2

Experimental Properties

  • Boiling Point: 428.3°C at 760 mmHg
  • Flash Point: 212.8°C
  • PSA: 36.26000
  • LogP: 4.61498

Citalopram hydrochloride Customs Data

  • HS CODE:2932999099
  • Customs Data:

    China Customs Code:

    2932999099

    Overview:

    2932999099. Other heterocyclic compounds containing only oxygen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Citalopram hydrochloride Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
Y0001007
85118-27-0
¥1556.59 2023-01-13
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$ 253.00 2023-09-08
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$540.00 2023-05-18
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C504820-50mg
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$ 1016.00 2023-09-08
TRC
C504820-100mg
Citalopram Hydrochloride
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$ 1918.00 2023-09-08
XI GE MA AO DE LI QI ( SHANG HAI ) MAO YI Co., Ltd.
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Citalopram hydrochloride
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¥1606.75 2025-01-16

Citalopram hydrochloride Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Dimethylformamide ;  rt → 80 °C; 24 h, 80 °C
1.2 Reagents: Hydrochloric acid Solvents: Diethyl ether ,  Dichloromethane ;  rt
Reference
Synthesis and biological properties of new 5-cyano-1,1-disubstituted phthalans for the treatment of premature ejaculation
Kim, Dong Sung; Kang, Kyung Koo; Lee, Kyung Seok; Ahn, Byoung Ok; Yoo, Moohi; et al, Bulletin of the Korean Chemical Society, 2008, 29(10), 1946-1950

Citalopram hydrochloride Preparation Products

Additional information on Citalopram hydrochloride

Comprehensive Guide to Citalopram Hydrochloride (CAS No. 85118-27-0): Properties, Applications, and Market Insights

Citalopram hydrochloride (CAS No. 85118-27-0) is a widely recognized selective serotonin reuptake inhibitor (SSRI) primarily used in the treatment of depression and anxiety disorders. With the increasing global focus on mental health, this compound has gained significant attention in both medical and pharmaceutical communities. Its molecular formula is C20H22FN1O·HCl, and it is known for its efficacy in balancing serotonin levels in the brain.

The demand for Citalopram HCl has surged in recent years, driven by rising awareness of mental wellness and the growing prevalence of depressive disorders. Patients and healthcare providers frequently search for terms like "Citalopram hydrochloride uses," "Citalopram side effects," and "Citalopram dosage guidelines," reflecting the need for reliable information. This article aims to provide a detailed overview of this compound, addressing common queries while adhering to SEO optimization principles.

From a chemical perspective, Citalopram hydrochloride is a white crystalline powder with a solubility of approximately 14 mg/mL in water. Its mechanism of action involves inhibiting the reuptake of serotonin, a neurotransmitter linked to mood regulation. This property makes it a cornerstone in the management of major depressive disorder (MDD) and generalized anxiety disorder (GAD).

The applications of Citalopram HCl extend beyond traditional depression treatment. Recent studies have explored its potential in addressing panic disorders, obsessive-compulsive disorder (OCD), and even certain types of chronic pain. These emerging uses have sparked interest in the pharmaceutical industry, with researchers investigating novel formulations and delivery methods to enhance patient outcomes.

Market trends indicate a steady growth trajectory for Citalopram hydrochloride, particularly in regions with aging populations and increasing mental health awareness. The compound's patent expiration has led to the development of numerous generic versions, making it more accessible to patients worldwide. Industry reports suggest that the global SSRI market, including Citalopram, is projected to expand at a compound annual growth rate (CAGR) of 3.5% over the next decade.

Quality control is paramount in the production of Citalopram HCl. Manufacturers must adhere to strict Good Manufacturing Practices (GMP) to ensure purity, potency, and consistency. Analytical techniques such as high-performance liquid chromatography (HPLC) and mass spectrometry are routinely employed to verify the compound's chemical integrity.

Patients considering Citalopram therapy often search for information on "Citalopram vs other SSRIs" or "how long does Citalopram take to work." Clinical data suggests that while individual responses vary, most patients experience noticeable improvements within 4-6 weeks of consistent use. Healthcare professionals emphasize the importance of gradual dosage adjustments and regular monitoring to minimize potential side effects.

Environmental considerations have also come to the forefront regarding pharmaceutical compounds like Citalopram hydrochloride. Recent research has focused on developing more sustainable synthesis methods and improving wastewater treatment processes to reduce the ecological impact of pharmaceutical manufacturing.

In conclusion, Citalopram hydrochloride (CAS No. 85118-27-0) remains a vital tool in modern psychiatry, with ongoing research expanding its therapeutic potential. As mental health continues to gain recognition as a global priority, the demand for reliable information about this SSRI medication will undoubtedly persist. This comprehensive overview addresses both technical aspects and patient-centered concerns, making it a valuable resource for diverse audiences.

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