Production Method 1

82104-74-3

85118-25-8

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ,  Water ;  1.5 h, 80 °C

Reference

Transition metal-free sodium borohydride-promoted controlled hydration of nitriles to amides

Verma, Praveen Kumar; Kumar, Neeraj; Sharma, Upendra; Bala, Manju; Kumar, Vishal; et al, Synthetic Communications, 2013, 43(21), 2867-2875

Production Method 2

227954-90-7

85118-25-8

Reaction Conditions

1.1 Reagents: Ammonium hydroxide Solvents: Tetrahydrofuran ,  Water ;  30 min, cooled

Reference

Synthesis of 5-(chlorocarbonyl)phthalide

Wang, Jingwei; Sun, Li, Heilongjiang Yiyao, 2009, 22(4), 499-500

Production Method 3

64169-34-2

82102-37-2

85118-25-8

Reaction Conditions

1.1 Reagents: Diisopropylethylamine Catalysts: Bis(dibenzylideneacetone)palladium ,  Tri-tert-butylphosphonium tetrafluoroborate Solvents: 1,4-Dioxane ;  20 h, 100 °C
1.2 Reagents: Sodium bicarbonate ,  Ammonium carbamate Catalysts: Bis(dibenzylideneacetone)palladium ,  (2R)-1-[(1R)-1-[Bis(1,1-dimethylethyl)phosphino]ethyl]-2-(diphenylphosphino)ferr… Solvents: 1,4-Dioxane ;  20 h, 100 °C

Reference

Palladium-Catalyzed Approach to Primary Amides Using Nongaseous Precursors

Nielsen, Dennis U.; Taaning, Rolf H.; Lindhardt, Anders T.; Gogsig, Thomas M.; Skrydstrup, Troels, Organic Letters, 2011, 13(16), 4454-4457

5-Carbamoylphthalide Raw materials

• 5-bromo-1,3-dihydro-2-benzofuran-1-one
• 5-Cyanophthalide
• 9-Methylfluorene-9-carbonyl Chloride
• 5-Isobenzofurancarbonylchloride, 1,3-dihydro-1-oxo-

5-Carbamoylphthalide Preparation Products

• 5-Carbamoylphthalide (85118-25-8)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isocoumarans Phthalides
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Isocoumarans Isobenzofuranones Phthalides

• 771574-07-3(Benzoic acid,2-(aminomethyl)-, ethyl ester)
• 75985-08-9(Benzoic acid, 3-(aminomethyl)-2-methyl-, ethyl ester)
• 89760-82-7(Benzoic acid, 3-(aminomethyl)-, (2,4,6-trimethylphenyl)methyl ester, hydrochloride (1:1))
• 63037-42-3(1,4-Benzenedicarboxylic acid, 2,5-bis(aminocarbonyl)-, dimethyl ester)
• 6757-31-9(Methyl 4-carbamoylbenzoate)
• 126926-41-8(Benzamide,3-[(acetyloxy)methyl]-)
• 650602-26-9(Benzamide, 4-[(acetyloxy)methyl]-)
• 106748-24-7(Methyl 3-carbamoylbenzoate)
• 78950-33-1(Benzoic acid,3-(aminocarbonyl)-, ethyl ester)
• 89760-85-0(Benzoic acid, 3-(aminomethyl)-, (2,4,6-trimethylphenyl)methyl ester)