Production Method 1

35730-09-7

85118-03-2

Reaction Conditions

1.1 Reagents: Ammonia Solvents: Dichloromethane ,  Water ;  0 °C; 1 h, rt
1.2 Reagents: Water ;  rt

Reference

Iridium-Catalyzed Ligand-Controlled Remote para-Selective C-H Activation and Borylation of Twisted Aromatic Amides

Hoque, Emdadul Md; Bisht, Ranjana; Unnikrishnan, Anju; Dey, Sayan; Mahamudul Hassan, Mirja Md; et al, Angewandte Chemie, 2022, 61(27),

Production Method 2

55-21-0

85118-03-2

455-37-8

763102-63-2

763102-62-1

Reaction Conditions

1.1 Reagents: Hydrofluoric acid Solvents: Diethyl ether ,  Acetone ;  19 h, -5 °C
1.2 Reagents: Sodium fluoride Solvents: Diethyl ether ;  neutralized

Reference

Electrochemical fluorination of benzamide and acetanilide in anhydrous HF and in acetonitrile

Shainyan, B. A.; Danilevich, Yu. S.; Grigor'eva, A. A.; Chuvashev, Yu. A., Russian Journal of Organic Chemistry (Translation of Zhurnal Organicheskoi Khimii), 2004, 40(4), 513-517

2,5-Difluorobenzamide Raw materials

• Benzamide
• 2,5-Difluorobenzoyl chloride

2,5-Difluorobenzamide Preparation Products

• 3-Fluorobenzamide (455-37-8)
• 2,5-Difluorobenzamide (85118-03-2)
• 1,4-Cyclohexadiene-1-carboxamide, 2,3,3,6,6-pentafluoro- (763102-63-2)
• 1,4-CYCLOHEXADIENE-1-CARBOXAMIDE, 3,3,6,6-TETRAFLUORO- (763102-62-1)

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