Production Method 1

6334-18-5

85070-48-0

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Tetraphenylphosphonium bromide ,  18-Crown-6 Solvents: Benzene ,  Nitrobenzene ;  0.5 h, 215 °C

Reference

Microwave-assisted fluorination in the presence of tetraphenylphosphonium bromide

Li, Bindong; Liang, Zhengyong; Lu, Chunxu, Jingxi Shiyou Huagong, 2007, 24(5), 25-28

Production Method 2

6334-18-5

85070-48-0

Reaction Conditions

1.1 Reagents: Potassium fluoride Catalysts: Tetraphenylphosphonium bromide ,  2,2,7,7,12,12,17,17-Octamethyl-21,22,23,24-tetraoxapentacyclo[16.2.1.13,6.18,11.… Solvents: Benzene ,  3,4-Dichlorotoluene ;  210 °C
1.2 0.5 h, 216 °C

Reference

Synthesis of fluorinated benzaldehydes and diphenyl ketones via halogen-exchange fluorination promoted by microwave

Liang, Zhengyong; Lu, Chunxu; Li, Bindong, Huaxue Tongbao, 2006, 69(11), 836-840

Production Method 3

85070-47-9

85070-48-0

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Ethanol ;  10 min, 0 °C
1.2 Reagents: 2-Nitropropane ;  10 min, 0 °C
1.3 3.5 h, rt

Reference

Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties

Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; et al, Bioorganic & Medicinal Chemistry, 2009, 17(24), 8206-8220

Production Method 4

6334-18-5

85070-48-0

Reaction Conditions

Reference

Fluorination of chlorobenzaldehydes with alkali metal fluorides in the presence of phase transfer catalysts

, Federal Republic of Germany, , ,

3-Chloro-2-fluorobenzaldehyde Raw materials

• 1-(bromomethyl)-3-chloro-2-fluorobenzene
• 2,3-Dichlorobenzaldehyde

3-Chloro-2-fluorobenzaldehyde Preparation Products

• 3-Chloro-2-fluorobenzaldehyde (85070-48-0)

• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives
• Solvents and Organic Chemicals Organic Compounds Aldehyde/Ketone

• 61072-56-8(4-Chloro-2-fluorobenzaldehyde)
• 96515-79-6(5-Chloro-2-fluorobenzaldehyde)
• 127675-46-1(3-Chloro-2,4-difluorobenzaldehyde)
• 1160573-23-8(4-Chloro-2,3-difluorobenzaldehyde)
• 34328-61-5(3-Chloro-4-fluorobenzaldehyde)
• 695187-29-2(5-Chloro-2,4-difluorobenzaldehyde)
• 101513-80-8(3-Chloro-2,4,5-trifluorobenzaldehyde)
• 190011-87-1(3-Chloro-2,6-difluorobenzaldehyde)
• 252004-45-8(4-Chloro-2,6-difluorobenzaldehyde)
• 879093-02-4(4-Chloro-2,5-difluorobenzaldehyde)