Production Method 1

13091-23-1

850663-54-6

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Ammonia Catalysts: tert-Butyl hydroperoxide Solvents: Tetrahydrofuran ,  Decane ;  -78 °C → -35 °C; 5 min, 0 °C; 0 °C; 1.5 h, -35 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  16 h, -35 °C → rt

Reference

Design and synthesis of a novel series of cyclohexyloxy-pyridyl derivatives as inhibitors of diacylglycerol acyl transferase 1

Plowright, Alleyn T.; Barton, Peter; Bennett, Stuart; Birch, Alan M.; Birtles, Susan; et al, MedChemComm, 2013, 4(1), 151-158

Production Method 2

13091-23-1

850663-54-6

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide ,  Ammonia Solvents: Tetrahydrofuran ;  -78 °C → -35 °C
1.2 Reagents: tert-Butyl hydroperoxide Solvents: Tetrahydrofuran ;  0 °C
1.3 Solvents: Tetrahydrofuran ;  30 min, -35 °C; 30 min, -35 °C; -35 °C → -78 °C
1.4 Reagents: Ammonium chloride Solvents: Water ;  -78 °C → rt

Reference

Identification and Optimization of Benzimidazole Sulfonamides as Orally Bioavailable Sphingosine 1-Phosphate Receptor 1 Antagonists with in Vivo Activity

Hennessy, Edward J.; Oza, Vibha; Adam, Ammar; Byth, Kate; Castriotta, Lillian; et al, Journal of Medicinal Chemistry, 2015, 58(17), 7057-7075

Production Method 3

13091-23-1

850663-54-6

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Potassium tert-butoxide ,  Ammonia Solvents: Tetrahydrofuran

Reference

Syntheses of 4- and 6-substituted thiazolo[4,5-c]pyridines

Huang, Yuhua; Bennett, Frank; Girijavallabhan, Vinay; Alvarez, Carmen; Chan, Tze-Ming; et al, Tetrahedron Letters, 2010, 51(21), 2800-2802

Production Method 4

13091-23-1

850663-54-6

Reaction Conditions

1.1 Solvents: Tetrahydrofuran ;  rt → -78 °C
1.2 Reagents: Potassium tert-butoxide ,  Ammonia ;  -78 °C → -35 °C
1.3 Solvents: Tetrahydrofuran ;  rt → 0 °C
1.4 Reagents: tert-Butyl hydroperoxide Solvents: Decane ;  5 min, 0 °C
1.5 1 h, -35 °C; 2 h, -35 °C
1.6 Reagents: Ammonium chloride Solvents: Water

Reference

Discovery of Aminofurazan-azabenzimidazoles as Inhibitors of Rho-Kinase with High Kinase Selectivity and Antihypertensive Activity

Stavenger, Robert A.; Cui, Haifeng; Dowdell, Sarah E.; Franz, Robert G.; Gaitanopoulos, Dimitri E.; et al, Journal of Medicinal Chemistry, 2007, 50(1), 2-5

Production Method 5

13091-23-1

850663-54-6

Reaction Conditions

1.1 Reagents: tert-Butyl hydroperoxide ,  Potassium tert-butoxide Solvents: Dimethylformamide ,  Decane ;  -35 °C; 2 h, -35 °C
1.2 Reagents: Ammonium chloride Solvents: Water ;  30 min, rt
1.3 Reagents: Potassium carbonate Solvents: Water ;  pH 8 - 9

Reference

Novel 2,4,5-trisubstituted pyridines as key intermediates for the preparation of the TSPO ligand 6-F-PBR28: Synthesis and full 1H and 13C NMR characterization

Damont, Annelaure; Lemee, Frederic; Raggiri, Guillaume; Dolle, Frederic, Journal of Heterocyclic Chemistry, 2014, 51(2), 404-410

4-chloro-5-nitro-1,2-dihydropyridin-2-one Raw materials

• 4-Chloro-3-nitropyridine

4-chloro-5-nitro-1,2-dihydropyridin-2-one Preparation Products

• 4-chloro-5-nitro-1,2-dihydropyridin-2-one (850663-54-6)

• 1. An integrated cathode and solid electrolyte via in situ polymerization with significantly reduced interface resistance?
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• 2. An algal process treatment combined with the Fenton reaction for high concentrations of amoxicillin and cefradine
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• 3. Acenaphthenic hopanoids, a novel series of aromatised
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• 4. An approach to biodegradable star polymeric architectures using disulfide coupling?
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• 5. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383

• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds C-nitro compounds
• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds Organic nitro compounds C-nitro compounds

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