Production Method 1

153556-42-4

849758-12-9

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Methanol ;  3 h, 50 °C

Reference

Topoisomerase Inhibitors Addressing Fluoroquinolone Resistance in Gram-Negative Bacteria

Skepper, Colin K. ; Armstrong, Duncan; Balibar, Carl J.; Bauer, Daniel; Bellamacina, Cornelia; et al, Journal of Medicinal Chemistry, 2020, 63(14), 7773-7816

Production Method 2

153556-42-4

18107-18-1

849758-12-9

Reaction Conditions

1.1 Solvents: Methanol ,  Tetrahydrofuran ;  1 h, 0 °C → rt

Reference

Design, Synthesis, and Structure-Activity Relationship of a Novel Series of GluN2C-Selective Potentiators

Zimmerman, Sommer S.; Khatri, Alpa; Garnier-Amblard, Ethel C.; Mullasseril, Praseeda; Kurtkaya, Natalie L.; et al, Journal of Medicinal Chemistry, 2014, 57(6), 2334-2356

Production Method 3

153556-42-4

849758-12-9

Reaction Conditions

1.1 Reagents: Thionyl chloride ;  0 °C; 18 h, rt

Reference

Imaging of I2-imidazoline receptors by small-animal PET using 2-(3-fluoro-[4-11C]tolyl)-4,5-dihydro-1H-imidazole ([11C]FTIMD)

Kawamura, Kazunori; Naganawa, Mika; Konno, Fujiko; Yui, Joji; Wakizaka, Hidekatsu; et al, Nuclear Medicine and Biology, 2010, 37(5), 625-635

Methyl 4-bromo-3-fluorobenzoate Raw materials

• 4-Bromo-3-fluorobenzoic acid
• (diazomethyl)trimethylsilane

Methyl 4-bromo-3-fluorobenzoate Preparation Products

• Methyl 4-bromo-3-fluorobenzoate (849758-12-9)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

• 153556-42-4(4-Bromo-3-fluorobenzoic acid)
• 647020-71-1(2-Bromo-3-fluorobenzoic acid methyl ester)
• 82702-31-6(Methyl 3-bromo-4-fluorobenzoate)
• 1130165-74-0(Ethyl 4-bromo-3-fluorobenzoate)
• 1193162-21-8(Methyl 4-bromo-2,5-difluorobenzoate)
• 1352889-89-4(Methyl 4-Bromo-5-fluoro-2-methylbenzoate)
• 23233-33-2(3-Bromo-4-fluoro-benzoic Acid Ethyl Ester)
• 334792-52-8(Methyl 3-bromo-5-fluorobenzoate)
• 801303-25-3(Benzoic acid, 4-bromo-3-fluoro-, phenylmethyl ester)
• 1244642-70-3(Methyl 3-bromo-4,5-difluorobenzoate)