Production Method 1

144690-04-0

849206-42-4

Reaction Conditions

1.1 Reagents: Tosyl chloride ,  Pyridine Solvents: Dichloromethane ;  12 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2
1.3 Reagents: Sodium bicarbonate ;  pH 9

Reference

A novel synthesis of olmesartan medoxomil and examination of its related impurities

Wu, Taizhi; Liu, Xiaohua; Zhang, Fuli; Xie, Meihua, Yaoxue Xuebao, 2006, 41(6), 537-543

Production Method 2

144690-04-0

849206-42-4

Reaction Conditions

1.1 Reagents: Dicyclohexylcarbodiimide Solvents: Acetone ;  45 h, rt
1.2 Reagents: Hydrochloric acid Solvents: Water ;  pH 2 - 3, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  pH 7 - 8, rt

Reference

Identification, Synthesis, and Comprehension of an Imidazole N-3 Regioisomeric Impurity of Olmesartan Medoxomil Key Intermediate

Lu, Jianwu ; Li, Xiao; Yuan, Shun; Wang, Yinquan; Sun, Han; et al, Organic Process Research & Development, 2022, 26(4), 1247-1257

3,6-dihydro-6,6-dimethyl-2-propyl-4H-Furo[3,4-d]imidazol-4-one Raw materials

• 4-(1-Hydroxy-1-methylethyl)-2-propylimidazole-5-carboxylic acid

3,6-dihydro-6,6-dimethyl-2-propyl-4H-Furo[3,4-d]imidazol-4-one Preparation Products

• 3,6-dihydro-6,6-dimethyl-2-propyl-4H-Furo[3,4-d]imidazol-4-one (849206-42-4)

• 1. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 2. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 3. Acentric and chiral heterometallic inorganic–organic hybrid frameworks mediated by alkali or alkaline earth ions: synthesis and NLO properties
  Huabin Zhang,Shaowu Du CrystEngComm, 2014,16, 4059-4068
• 4. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219
• 5. An artificial enzyme cascade amplification strategy for highly sensitive and specific detection of breast cancer-derived exosomes?
  Huiying Xu,Lu Zheng,Yu Zhou,Bang-Ce Ye Analyst, 2021,146, 5542-5549

• 172875-53-5(Ethyl 4-(2-hydroxybutan-2-yl)-2-propyl-1H-imidazole-5-carboxylate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)