Production Method 1

5655-01-6

84905-80-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  3 h, reflux; cooled
1.2 Reagents: Sodium hydroxide ;  pH 6, cooled

Reference

Aromatic N versus aromatic F: bioisosterism discovered in RNA base pairing interactions leads to a novel class of universal base analogs

Koller, Alrun N.; Bozilovic, Jelena; Engels, Joachim W.; Gohlke, Holger, Nucleic Acids Research, 2010, 38(9), 3133-3146

Production Method 2

5655-01-6

84905-80-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  1 h, reflux; reflux → 35 °C; cooled
1.2 Reagents: Ammonium hydroxide Solvents: Water ;  pH 7.0 - 8.5, cooled

Reference

Development of a Practical Synthesis of a Purine Nucleoside Phosphorylase Inhibitor: BCX-4208

Kamath, Vivekanand P.; Juarez-Brambila, Jesus J.; Morris, Christopher B.; Winslow, Christopher D.; Morris, Philip E., Organic Process Research & Development, 2009, 13(5), 928-932

Production Method 3

5655-01-6

84905-80-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  5 h, reflux
1.2 Reagents: Sodium hydroxide ,  Water Solvents: Water ;  neutralized, cooled

Reference

Synthesis of Immucillins BCX-1777 and BCX-4430 from a Common Precursor

Krishnakumar, K. A.; Lankalapalli, Ravi S., European Journal of Organic Chemistry, 2022, 2022(25),

Production Method 4

5655-01-6

84905-80-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  90 min, reflux

Reference

Novel Substituted Purine Isosteres: Synthesis, Structure-Activity Relationships and Cytotoxic Activity Evaluation

Dimitrakis, Spyridon; Gavriil, Efthymios-Spyridon; Pousias, Athanasios; Lougiakis, Nikolaos ; Marakos, Panagiotis; et al, Molecules, 2022, 27(1),

Production Method 5

5655-01-6

84905-80-6

Reaction Conditions

1.1 Reagents: Phosphorus oxychloride ;  4 h, 100 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized, cooled

Reference

An Access to the β-Anomer of 4'-Thio-C-ribonucleosides: Hydroboration of 1-C-Aryl- or 1-C-Heteroaryl-4-thiofuranoid Glycals and Its Regiochemical Outcome

Haraguchi, Kazuhiro; Horii, Chikafumi; Yoshimura, Yuichi; Ariga, Fumiko; Tadokoro, Aya; et al, Journal of Organic Chemistry, 2011, 76(21), 8658-8669

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine Raw materials

• 1H-Pyrrolo3,2-Dpyrimidin-4(5H)-one

4-Chloro-5H-pyrrolo[3,2-d]pyrimidine Preparation Products

• 4-Chloro-5H-pyrrolo[3,2-d]pyrimidine (84905-80-6)

• 1. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Evolution and characterization of a benzylguanine-binding RNA aptamer?
  J. Xu,T. J. Carrocci,A. A. Hoskins Chem. Commun., 2016,52, 549-552
• 5. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyrimidines Pyrrolopyrimidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolopyrimidines

• 107400-97-5(4-Chloro-5H-pyrimido5,4-bindole HCl)
• 175358-02-8(4,6-Dichloropyrido[3,2-d]pyrimidine)
• 98792-02-0(4-chloro-5H-pyrimido5,4-bindole)
• 2589-12-0(4,6-Dichloro-1H-imidazo[4,5-c]pyridine)
• 51674-77-2(4-Chloropyrido[3,2-d]pyrimidine)
• 39551-54-7(2,4-Dichloropyrido[3,2-D]pyrimidine)
• 2770-01-6(4-Chloro-1H-imidazo4,5-cpyridine)
• 189747-34-0(2,8-dichloropyrimido[5,4-d][1,3]diazine)
• 63200-54-4(2,4-Dichloro-5H-pyrrolo[3,2-d]pyrimidine)
• 917757-12-1(4,7-dichloropyrido[3,2-d]pyrimidine)