Production Method 1

3510-66-5

1116-98-9

848093-05-0

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Tetrahydrofuran ,  1,4-Dioxane ;  5 min, rt
1.2 Catalysts: Dichloro[1,1′-bis(diphenylphosphino)ferrocene]palladium(II) dichloromethane addu… Solvents: 1,4-Dioxane ;  21 h, 70 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  1 h, 60 °C; 18 h, reflux; reflux → rt
1.4 Reagents: Sodium hydroxide Solvents: Water ;  pH 14, rt
1.5 Reagents: Hydrochloric acid Solvents: Water ;  4 h, rt

Reference

Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

Orr, Suvi T. M.; Beveridge, Ramsay; Bhattacharya, Samit K.; Cameron, Kimberly O.; Coffey, Steven; et al, ACS Medicinal Chemistry Letters, 2015, 6(2), 156-161

2-(5-methyl-2-pyridyl)acetic acid Raw materials

• 2-Bromo-5-methylpyridine
• tert-Butyl 2-cyanoacetate

2-(5-methyl-2-pyridyl)acetic acid Preparation Products

• 2-(5-methyl-2-pyridyl)acetic acid (848093-05-0)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Methylpyridines

• 13115-43-0(2-(Pyridin-2-yl)acetic acid)
• 897016-92-1(2-Pyridineacetic acid, 5-phenyl-)
• 1201194-56-0(2-(5-methyl-2-pyridyl)acetic acid;hydrochloride)
• 1251919-69-3(2-Pyridineacetic acid, 3-methyl-, potassium salt (1:1))
• 149605-62-9(2-(4-methylpyridin-2-yl)acetic acid)
• 1000565-37-6(2-(3-Methylpyridin-2-yl)acetic acid)
• 54363-97-2(Pyridineacetic acid)
• 121131-75-7(2-(5-Cyclopropylpyridin-2-yl)acetic acid)
• 19946-10-2(Methyl 2-(5-methylpyridin-2-yl)acetate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)