• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400

Introduction to 5-(4-Fluorophenyl)-2-hydroxybenzaldehyde (CAS No. 847754-82-9)

5-(4-Fluorophenyl)-2-hydroxybenzaldehyde, also known by its CAS number 847754-82-9, is a synthetic organic compound that has garnered significant attention in recent years due to its unique chemical structure and potential applications in various fields, particularly in medicinal chemistry and materials science. This compound is characterized by its aromatic ring system, a hydroxyl group, and a fluorinated phenyl substituent, which collectively contribute to its distinctive properties and reactivity.

The molecular formula of 5-(4-fluorophenyl)-2-hydroxybenzaldehyde is C₁₃H₁₀FNO₂, with a molecular weight of approximately 231.22 g/mol. The presence of the hydroxyl group and the fluorine atom imparts polarity and electronic effects that influence its chemical behavior, making it an interesting candidate for various synthetic transformations and biological studies.

In the realm of medicinal chemistry, 5-(4-fluorophenyl)-2-hydroxybenzaldehyde has been explored for its potential as a lead compound in drug discovery. Recent research has highlighted its anti-inflammatory and antioxidant properties, which are attributed to the presence of the hydroxyl group and the fluorinated phenyl ring. These properties make it a promising candidate for the development of new therapeutic agents targeting inflammatory diseases and oxidative stress-related conditions.

A study published in the Journal of Medicinal Chemistry in 2021 investigated the anti-inflammatory effects of 5-(4-fluorophenyl)-2-hydroxybenzaldehyde. The researchers found that this compound effectively inhibited the production of pro-inflammatory cytokines such as TNF-α and IL-6 in lipopolysaccharide (LPS)-stimulated macrophages. This suggests that 5-(4-fluorophenyl)-2-hydroxybenzaldehyde could be a valuable starting point for the development of novel anti-inflammatory drugs.

Beyond its medicinal applications, 5-(4-fluorophenyl)-2-hydroxybenzaldehyde has also been studied for its potential use in materials science. The unique electronic properties conferred by the fluorine atom and the hydroxyl group make it an attractive building block for the synthesis of functional materials with enhanced optical and electronic properties. For instance, a study published in the Journal of Materials Chemistry C in 2020 reported the use of 5-(4-fluorophenyl)-2-hydroxybenzaldehyde as a precursor for the preparation of luminescent organic materials with tunable emission properties.

The synthetic route to produce 5-(4-fluorophenyl)-2-hydroxybenzaldehyde typically involves multi-step processes, including aromatic substitution reactions, oxidation steps, and functional group manipulations. One common approach involves starting from 4-fluorobenzeneboronic acid and 3-hydroxybenzaldehyde, which are coupled via a Suzuki coupling reaction followed by further functionalization steps to introduce the desired substituents.

The stability and solubility of 5-(4-fluorophenyl)-2-hydroxybenzaldehyde are important considerations for both research and industrial applications. This compound is generally stable under standard laboratory conditions but may require careful handling to avoid degradation or unwanted side reactions. Its solubility in organic solvents such as dimethyl sulfoxide (DMSO) and ethanol makes it suitable for various experimental protocols.

In conclusion, 5-(4-fluorophenyl)-2-hydroxybenzaldehyde (CAS No. 847754-82-9) is a versatile compound with a wide range of potential applications in medicinal chemistry, materials science, and other related fields. Its unique chemical structure, characterized by the presence of a hydroxyl group and a fluorinated phenyl ring, endows it with valuable properties that make it an attractive candidate for further research and development. As ongoing studies continue to uncover new insights into its behavior and potential uses, this compound is likely to play an increasingly important role in advancing scientific knowledge and technological innovation.

• 1111120-19-4(5-(5-fluoro-2-hydroxyphenyl)-2-hydroxybenzaldehyde)
• 1111129-23-7(5-(2-fluoro-5-methylphenyl)-2-hydroxybenzaldehyde)
• 1111129-25-9(5-(3,4-difluorophenyl)-2-hydroxybenzaldehyde)
• 1098984-26-9(5-(3-fluoro-4-hydroxyphenyl)-2-hydroxybenzaldehyde)
• 1111128-91-6(4-(4-Fluoro-3-methylphenyl)-2-formylphenol)
• 343603-87-2(3-(4-fluorophenyl)-2-hydroxybenzaldehyde)
• 1111129-22-6(5-(5-fluoro-2-methylphenyl)-2-hydroxybenzaldehyde)
• 1111129-11-3(5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde)
• 1111129-26-0(4-(3-Fluoro-4-methylphenyl)-2-formylphenol)
• 704884-74-2(5-Fluoro-2-hydroxy-3-methylbenzaldehyde)