Cas no 1111129-11-3 (5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde)

5-(3,5-Difluorophenyl)-2-hydroxybenzaldehyde is a fluorinated aromatic aldehyde featuring a hydroxyl group ortho to the formyl functionality. This compound is of interest in synthetic organic chemistry due to its bifunctional reactivity, enabling its use as a versatile intermediate in the preparation of pharmaceuticals, agrochemicals, and advanced materials. The presence of electron-withdrawing difluorophenyl and electron-donating hydroxyl groups enhances its utility in selective transformations, such as condensation and nucleophilic substitution reactions. Its structural motif is particularly valuable in designing bioactive molecules, where fluorination improves metabolic stability and binding affinity. The compound is typically handled under controlled conditions due to its sensitivity to oxidation and light.
5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde structure
1111129-11-3 structure
Product Name:5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde
CAS No:1111129-11-3
MF:C13H8F2O2
MW:234.198230743408
MDL:MFCD11877732
CID:1195729
PubChem ID:53220377
Update Time:2025-06-14

5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde Chemical and Physical Properties

Names and Identifiers

    • 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde
    • MFCD11877732
    • 3',5'-Difluoro-4-hydroxy[1,1'-biphenyl]-3-carbaldehyde
    • DTXSID50685124
    • 4-(3,5-Difluorophenyl)-2-formylphenol, 95%
    • 4-(3,5-DIFLUOROPHENYL)-2-FORMYLPHENOL
    • 1111129-11-3
    • MDL： MFCD11877732
    • Inchi： 1S/C13H8F2O2/c14-11-4-9(5-12(15)6-11)8-1-2-13(17)10(3-8)7-16/h1-7,17H
    • InChI Key： YZAVZGLOTCSVJX-UHFFFAOYSA-N
    • SMILES： FC1C=C(C=C(C=1)C1C=CC(=C(C=O)C=1)O)F

Computed Properties

  • Exact Mass: 234.04923582g/mol
  • Monoisotopic Mass: 234.04923582g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 17
  • Rotatable Bond Count: 2
  • Complexity: 262
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 3.4
  • Topological Polar Surface Area: 37.3?2

5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde Pricemore >>

Related Categories No. Product Name Cas No. Purity Specification Price update time Inquiry
abcr
AB320782-5 g
4-(3,5-Difluorophenyl)-2-formylphenol, 95%; .
 1111129-11-3 95%
5g
 €1159.00 2023-04-26
abcr
AB320782-5g
4-(3,5-Difluorophenyl)-2-formylphenol, 95%; .
 1111129-11-3 95%
5g
 €1159.00 2025-04-22

5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde Related Literature

Related Categories

Additional information on 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde

Exploring 5-(3,5-Difluorophenyl)-2-Hydroxybenzaldehyde (CAS No. 1111129-11-3): A Versatile Building Block in Modern Organic Synthesis

In the realm of organic chemistry, 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde (CAS No. 1111129-11-3) has emerged as a pivotal intermediate for designing complex molecular architectures. This compound, characterized by its difluorophenyl and hydroxybenzaldehyde moieties, offers unique electronic and steric properties that make it invaluable in pharmaceuticals, agrochemicals, and materials science. Researchers are increasingly focusing on its role in cross-coupling reactions and Schiff base formation, aligning with the growing demand for sustainable and efficient synthetic methodologies.

The structural features of 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde—particularly the fluorine substituents—enhance its reactivity in palladium-catalyzed reactions, a hotspot in modern drug discovery. Fluorinated compounds like this are often explored for their potential in bioactive molecule design, addressing challenges such as metabolic stability and target selectivity. Recent publications highlight its utility in constructing heterocyclic scaffolds, a trend driven by the pharmaceutical industry's quest for novel kinase inhibitors and antimicrobial agents.

From an industrial perspective, the compound’s synthesis and applications resonate with the broader shift toward green chemistry. Optimized protocols for producing 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde now emphasize atom economy and catalyst recycling, reflecting the global emphasis on reducing chemical waste. These advancements align with frequent search queries like "fluorinated aldehydes in drug development" or "eco-friendly synthesis of aromatic aldehydes," underscoring the intersection of academic research and industrial innovation.

Another compelling aspect of this compound lies in its potential for material science applications. The hydroxybenzaldehyde core can serve as a precursor for luminescent materials and metal-organic frameworks (MOFs), topics gaining traction in nanotechnology forums. Its ability to coordinate with transition metals opens doors to catalysis and sensor development, areas frequently searched by engineers and chemists exploring smart materials.

In summary, 5-(3,5-difluorophenyl)-2-hydroxybenzaldehyde (CAS No. 1111129-11-3) exemplifies the synergy between structural ingenuity and practical utility. As interest grows in fluorine chemistry and multifunctional intermediates, this compound is poised to remain a cornerstone in both academic and industrial research, answering the call for innovative solutions in synthetic and applied chemistry.

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