Production Method 1

16110-09-1

847664-64-6

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -78 °C; 1 h, -78 °C
1.2 Reagents: Triisopropyl borate Solvents: Tetrahydrofuran ;  -78 °C → rt; 2 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  0.5 h, rt

Reference

Design, Synthesis, and Structure-Activity Relationship of Tetrahydropyrido[4,3-d]pyrimidine Derivatives as Potent Smoothened Antagonists with in Vivo Activity

Lu, Wenfeng; Liu, Yongqiang; Ma, Haikuo; Zheng, Jiyue; Tian, Sheng; et al, ACS Chemical Neuroscience, 2017, 8(9), 1980-1994

Production Method 2

16110-09-1

847664-64-6

Reaction Conditions

1.1 Reagents: Lithium diisopropylamide Solvents: Tetrahydrofuran ;  -80 °C; 1 h, -80 °C
1.2 Reagents: Triisopropyl borate Solvents: Tetrahydrofuran ;  -80 °C; -80 °C → rt; 1 h, rt
1.3 Reagents: Sodium hydroxide Solvents: Water ;  rt
1.4 Reagents: Hydrochloric acid Solvents: Water ;  < 5 °C

Reference

Efficient synthesis of halohydroxypyridines by hydroxydeboronation

Voisin, Anne Sophie; Bouillon, Alexandre; Lancelot, Jean-Charles; Rault, Sylvain, Tetrahedron, 2005, 61(6), 1417-1421

(2,5-dichloropyridin-4-yl)boronic acid Raw materials

• 2,5-Dichloropyridine

(2,5-dichloropyridin-4-yl)boronic acid Preparation Products

• (2,5-dichloropyridin-4-yl)boronic acid (847664-64-6)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Halopyridines Polyhalopyridines
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

• 458532-98-4((3-Chloropyridin-4-yl)boronic acid)
• 536693-97-7(2,5-Dichloropyridine-3-boronic acid)
• 1070893-11-6((4,6-Dichloropyridin-3-yl)boronic acid)
• 1072952-26-1((4,6-Dichloropyridin-3-yl)boronic acid hydrate)
• 1072951-54-2((2,6-Dichloropyridin-4-yl)boronic acid)
• 951677-39-7(2,3-Dichloropyridine-4-boronic acid)
• 458532-96-2(2-Chloropyridine-4-boronic acid)
• 1256355-22-2(3-Chloro-4-pyridineboronic acid hydrate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)