Production Method 1

73183-34-3

36276-24-1

847560-50-3

Reaction Conditions

1.1 Reagents: Potassium acetate Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: 1,4-Dioxane ;  8 h, 100 °C

Reference

Discovery of GSK1070916, a Potent and Selective Inhibitor of Aurora B/C Kinase

Adams, Nicholas D.; Adams, Jerry L.; Burgess, Joelle L.; Chaudhari, Amita M.; Copeland, Robert A.; et al, Journal of Medicinal Chemistry, 2010, 53(10), 3973-4001

4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde Raw materials

• Bis(pinacolato)diborane
• 3-Bromo-4-methylbenzaldehyde

4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde Preparation Products

• 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (847560-50-3)

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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoyl derivatives

• 859518-20-0(2-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde)
• 356570-53-1(2-(2,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane)
• 380151-85-9(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde)
• 269409-74-7(3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid)
• 128376-64-7(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde)
• 380151-86-0(3-Formylphenylboronic Acid Pinacol Ester)
• 515131-35-8(5-Carboxy-2-methylphenylboronic acid, pinacol ester)
• 1268350-47-5(3,4-Dimethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid)
• 1073354-66-1(4-Formyl-2-methylphenylboronic Acid Pinacol Ester)
• 303006-89-5(2,5-Dimethyl-1,4-phenylenediboronic acid, pinacol ester)