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  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Aminopyrimidines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Aminopyrimidines and derivatives

Comprehensive Guide to 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine (CAS No. 84737-30-4)

2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine (CAS No. 84737-30-4) is a specialized pyrimidine derivative widely used in pharmaceutical and agrochemical research. This compound belongs to the class of halogenated pyrimidines, known for their unique chemical properties and broad applications. The presence of chloro and trifluoromethyl groups enhances its reactivity, making it a valuable intermediate in synthetic chemistry.

The molecular formula of 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine is C₅H₂Cl₂F₃N₃, with a molecular weight of 229.99 g/mol. Its structure features a pyrimidine ring substituted with two chlorine atoms at positions 2 and 5, a trifluoromethyl group at position 6, and an amino group at position 4. This arrangement contributes to its stability and versatility in chemical reactions.

One of the key applications of 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine is in the development of pharmaceutical intermediates. Researchers utilize this compound to synthesize novel drug candidates, particularly in the fields of antiviral and anticancer therapies. Its ability to act as a building block for more complex molecules makes it indispensable in medicinal chemistry.

In the agrochemical sector, 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine serves as a precursor for crop protection agents. The trifluoromethyl group is known to enhance the bioactivity of pesticides, improving their efficacy against pests and diseases. This compound is particularly relevant in the context of sustainable agriculture, where the demand for eco-friendly agrochemicals is rising.

The synthesis of 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine typically involves halogenation and amination reactions. Advanced techniques such as microwave-assisted synthesis and catalyzed reactions are often employed to improve yield and purity. These methods align with the growing trend of green chemistry, which emphasizes efficiency and environmental responsibility.

Recent studies highlight the potential of 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine in material science. Its unique electronic properties make it a candidate for developing organic semiconductors and photovoltaic materials. This application is gaining traction due to the global push for renewable energy solutions and sustainable technologies.

From a commercial perspective, the market for 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine is expanding, driven by its diverse applications. Suppliers and manufacturers are focusing on high-purity grades to meet the stringent requirements of pharmaceutical and agrochemical industries. The compound is available in various forms, including powder and crystalline solid, catering to different research and industrial needs.

Safety and handling of 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine require adherence to standard laboratory protocols. While it is not classified as hazardous under normal conditions, proper personal protective equipment (PPE) such as gloves and goggles should be used. Storage recommendations include keeping the compound in a cool, dry place away from direct sunlight.

For researchers and industry professionals, sourcing high-quality 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine is crucial. Reputable suppliers provide detailed certificates of analysis (CoA) and material safety data sheets (MSDS) to ensure compliance with regulatory standards. This transparency is essential for applications in GMP-compliant environments.

In conclusion, 2,5-Dichloro-6-(trifluoromethyl)pyrimidin-4-amine (CAS No. 84737-30-4) is a multifaceted compound with significant roles in pharmaceuticals, agrochemicals, and material science. Its unique chemical properties and broad applicability make it a subject of ongoing research and commercial interest. As industries continue to innovate, the demand for this pyrimidine derivative is expected to grow, solidifying its position as a key intermediate in modern chemistry.

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