Production Method 1

19235-88-2

847225-56-3

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Dimethyl sulfoxide ;  10 min

Reference

Microwave-accelerated fluorodenitrations and nitrodehalogenations: expeditious routes to labeled PET ligands and fluoropharmaceuticals

La Beaume, Paul; Placzek, Michael; Daniels, Mathew; Kendrick, Ian; Ng, Patrick; et al, Tetrahedron Letters, 2010, 51(14), 1906-1909

Production Method 2

19235-88-2

847225-56-3

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Dimethylformamide ,  Tetrahydrofuran ;  15 min, 23 °C
1.2 Reagents: Sodium chloride Solvents: Water ;  23 °C

Reference

Tetrabutylammonium salt induced denitration of nitropyridines: synthesis of fluoro-, hydroxy-, and methoxypyridines

Kuduk, Scott D.; DiPardo, Robert M.; Bock, Mark G., Organic Letters, 2005, 7(4), 577-579

4-fluoropyridine-2-carbonitrile Raw materials

• 4-nitropyridine-2-carbonitrile

4-fluoropyridine-2-carbonitrile Preparation Products

• 4-fluoropyridine-2-carbonitrile (847225-56-3)

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• 97509-75-6(3-fluoropyridine-2-carbonitrile)
• 28489-31-8(4-fluoro-2,6-dimethylpyridine)
• 1807185-79-0(4-Fluoro-6-methylpicolinonitrile)
• 1427501-79-8(7-Fluoroisoquinoline-1-carbonitrile)
• 1427501-46-9(6-Fluoroisoquinoline-1-carbonitrile)
• 1369292-33-0(5-Fluoroisoquinoline-1-carbonitrile)
• 915720-64-8(5-Fluoro-6-methylpicolinonitrile)
• 766-16-5(4-Fluoro-2-methylpyridine)
• 86324-50-7(6-Fluoroquinoline-2-carbonitrile)
• 327056-62-2(5-Fluoro-2-pyridinecarbonitrile)