Production Method 1

84677-06-5

18107-18-1

84677-05-4

Reaction Conditions

1.1 Solvents: Diethyl ether ,  Methanol ;  rt

Reference

The Synthesis of α,α-Disubstituted α-Amino Acids via Ichikawa Rearrangement

Szczesniak, Piotr; Pieczykolan, Michal; Stecko, Sebastian, Journal of Organic Chemistry, 2016, 81(3), 1057-1074

Production Method 2

15159-67-8

84677-05-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran

Reference

A simple synthesis of 1-aminocyclopropane-1-carboxylic acid

Strazewski, Peter; Tamm, Christoph, Synthesis, 1987, (3), 298-9

Production Method 3

15159-67-8

84677-05-4

Reaction Conditions

1.1 Reagents: Benzyl bromide ,  Sodium bis(trimethylsilyl)amide Solvents: Tetrahydrofuran ;  16 h, 0 °C → 22 °C

Reference

Synthesis and evaluation of C8-substituted 4.5-spiro lactams as Glycogen Phosphorylase a inhibitors

Loughlin, Wendy A.; Schweiker, Stephanie S.; Jenkins, Ian D.; Henderson, Luke C., Tetrahedron, 2013, 69(5), 1576-1582

Production Method 4

15159-67-8

84677-05-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran

Reference

Facile new method for preparation of optically active protected proline

Yamaguchi, Jun-ichi; Ueki, Masaaki, Chemistry Letters, 1996, (8), 621-622

methyl 1-(benzyloxycarbonylamino)cyclopropanecarboxylate Raw materials

• 1-(Benzyloxycarbonylamino)cyclopropyl-1-carboxylic Acid
• Butanoic acid, 4-bromo-2-[[(phenylmethoxy)carbonyl]amino]-, methylester, (2S)-
• (diazomethyl)trimethylsilane

methyl 1-(benzyloxycarbonylamino)cyclopropanecarboxylate Preparation Products

• methyl 1-(benzyloxycarbonylamino)cyclopropanecarboxylate (84677-05-4)

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