Production Method 1

897-06-3

846-48-0

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Ethanol ,  Water ;  0.25 h, 22 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ,  Water ;  acidified
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized

Reference

Reduction of steroidal ketones with amine-boranes

Leontjev, A. E.; Vasiljeva, L. L.; Pivnitsky, K. K., Russian Chemical Bulletin (Translation of Izvestiya Akademii Nauk, 2004, 53(3), 703-708

Production Method 2

977-32-2

846-48-0

Reaction Conditions

1.1 Reagents: Potassium carbonate Solvents: Methanol ;  10 h, rt

Reference

An efficient and environmentally benign chemical synthesis of testolactone

Zinczuk, Juan; Bacigaluppo, Jose A.; Colombo, Maria I.; Cravero, Raquel M.; Gonzalez-sierra, Manuel; et al, Journal of the Brazilian Chemical Society, 2003, 14(6), 970-974

Production Method 3

2363-59-9

846-48-0

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Methanol
1.2 Reagents: Hydrochloric acid
1.3 Solvents: Dichloromethane

Reference

Synthetic studies toward 1α-hydroxytestosterone from testosterone

Gao, Hongwu; Dias, Jerry Ray, Proceedings of ECSOC-3, 2000, 1214, 1214-1228

Production Method 4

58-22-0

846-48-0

Reaction Conditions

1.1 Reagents: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Catalysts: tert-Butyldimethylsilyl chloride Solvents: 1,4-Dioxane ;  0 °C; 40 h, 0 °C → rt

Reference

A practical Δ1-dehydrogenation of Δ4-3-ketosteroids with DDQ in the presence of TBDMSCl at room temperature

Chen, Kaixiong; Liu, Chang; Deng, Le; Xu, Guangyu, Steroids, 2010, 75(7), 513-516

Production Method 5

17086-53-2

846-48-0

Reaction Conditions

1.1 Reagents: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone

Reference

New reagent for selective oxidation of steroidal allylic alcohols to αβ-unsaturated ketones

Burn, D.; Petrow, V.; Weston, G. O., Tetrahedron Letters, 1960, 14, 14-15

Production Method 6

897-06-3

846-48-0

Reaction Conditions

1.1 Reagents: Glucose Catalysts: 3(17)β-Hydroxysteroid dehydrogenase Solvents: Ethanol ,  Water ;  96 h, 24 - 26 °C

Reference

Formation of 5α steroids by biotransformation involving the 5α-reductase activity of Penicillium decumbens

Holland, Herbert L.; Dore, Sophia; Brown, Frances M., Steroids, 1994, 59(11), 642-7

Production Method 7

897-06-3

846-48-0

Reaction Conditions

1.1 Reagents: Sodium borohydride Solvents: Dimethylformamide ,  Water

Reference

Preparation of 3-oxo-17-hydroxy steroids

, German Democratic Republic, , ,

Production Method 8

58-22-0

846-48-0

Reaction Conditions

1.1 Reagents: tert-Butyldimethylsilyl chloride Solvents: Tetrahydrofuran ,  1,4-Dioxane ;  rt → 0 °C; 90 min, 0 °C
1.2 Reagents: 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone Solvents: Tetrahydrofuran ,  1,4-Dioxane ;  4 h, 0 °C; 12 h, 0 °C → rt

Reference

Novel protective group synthesis of androgen receptor modulators with steroidal and nonsteroidal scaffolds

Grill, Matthias; Patt, Melanie; Odermatt, Alex, ChemRxiv, 2019, 1, 1-13

Production Method 9

897-06-3

846-48-0

Reaction Conditions

1.1 Solvents: Ethanol ,  Water ;  7 d, 25 °C

Reference

Nostoc muscorum: a regioselective biocatalyst for 17-carbonyl reduction of androst-4-en-3,17-dione and androst-1,4-dien-3,17-dione

Faramarzi, Mohammad Ali; Yazdi, Mojtaba Tabatabaei; Ghostinroudi, Hadi; Amini, Mohsen; Ghasemi, Younes; et al, Annals of Microbiology (Milano, 2006, 56(3), 253-256

Production Method 10

63-05-8

846-48-0

Reaction Conditions

1.1 Catalysts: 3(17)β-Hydroxysteroid dehydrogenase ,  17β-Hydroxysteroid dehydrogenase Solvents: Water ;  12 h, 25 °C

Reference

Study on catalytic synthesis of boldenone by recombinant E. coli expressing 17β-hydroxysteroid dehydrogenase

Wu, Yuling; Shao, Minglong; Zhou, Wulin; Gao, Huifang; Zhang, Xian; et al, Huagong Xuebao (Chinese Edition), 2020, 71(7), 3229-3237

Production Method 11

58-22-0

846-48-0

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: NADPH-dehydrogenase Solvents: Water ;  48 h, pH 7, 70 °C

Reference

Old Yellow Enzyme-Catalyzed Dehydrogenation of Saturated Ketones

Schittmayer, Matthias; Glieder, Anton; Uhl, Michael K.; Winkler, Andreas; Zach, Simone; et al, Advanced Synthesis & Catalysis, 2011, 353, 268-274

Production Method 12

897-06-3

846-48-0

Reaction Conditions

1.1 Reagents: NADPH ,  Oxygen Solvents: Acetone ,  Water ;  1 h, pH 5.5, 30 °C

Reference

Asymmetric reduction of prochiral ketones by cell-free systems from Alcaligenes eutrophus

Madyastha, kattigere M.; Gururaja, Tarikere L., Journal of Chemical Technology and Biotechnology, 1994, 59(3), 249-55

Boldenone Raw materials

• 17beta-Acetoxyandrosta-1,4-dien-3-one
• Androstenedione
• Androsta-1,4-diene-3,17-dione
• Androsta-1,4-diene-3,17-diol, (3a,17b)-
• Testosterone
• Imp. D (EP): 3-Oxoandrosta-1,4-dien-17-ylPropanoate

Boldenone Preparation Products

• Boldenone (846-48-0)

• 1. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 2. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 4. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 5. Dissociative electron attachment to HGaF4 Lewis–Br?nsted superacid
  Marcin Czapla,Jack Simons Phys. Chem. Chem. Phys., 2018,20, 21739-21745

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Androgens and derivatives
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Steroids and steroid derivatives Androstane steroids Androgens and derivatives
• Solvents and Organic Chemicals Organic Compounds

• 1370450-74-0(3-oxocholest-1,4-dien-12beta-ol)
• 31084-38-5(Androsta-1,4-dien-3-one,17-hydroxy-7-methyl-, (7a,17b)-)
• 848-33-9(7,17-dihydroxy-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one)
• 1451064-17-7(15beta-hydroxypregna-1,4,20-trien-3-one)
• 862286-72-4((22E)-11beta-hydroxy-24-norcholesta-1,4,22-trien-3-one)
• 27833-18-7((8R,9S,10R,13S,14S,17R)-17-hydroxy-10,13-dimethyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one)
• 361432-76-0(d3-17β-Boldenone)
• 7801-17-4((11beta,17beta)-form-11,17-Dihydroxyandrosta-1,4-dien-3-one)
• 82068-95-9(12beta-hydroxy-24-norcholesta-1,4,22-trien-3-one)
• 30915-20-9(Androsta-1,4-dien-3-one,11,17-dihydroxy-, (11a,17b)-)