Production Method 1

71-47-6

84163-42-8

Reaction Conditions

1.1 Reagents: Chloride Solvents: Formic acid

Reference

Synthesis of 4-aminopiperidine

Yakhontov, L. N.; Yatsenko, S. V.; Rubtsov, M. V., Zhurnal Obshchei Khimii, 1958, 28, 3115-19

Production Method 2

84163-42-8

Reaction Conditions

1.1 Reagents: Acetic anhydride ;  1 h, 65 °C; 16 h, rt

Reference

Reformulating a Pharmacophore for 5-HT2A Serotonin Receptor Antagonists

Younkin, Jason; Gaitonde, Supriya A.; Ellaithy, Amr; Vekariya, Rakesh; Baki, Lia; et al, ACS Chemical Neuroscience, 2016, 7(9), 1292-1299

Production Method 3

84163-42-8

Reaction Conditions

1.1 Solvents: Acetic anhydride ;  1 h, rt → 60 °C; 60 °C → 0 °C
1.2 0 - 5 °C; 14 h, 0 - 5 °C

Reference

A simple and efficient method for the synthesis of 1,2-benzisoxazoles. A series of its potent acetylcholinesterase inhibitors

Basappa; Mantelingu, K.; Sadashiva, M. P.; Rangappa, K. S., Indian Journal of Chemistry, 2004, (9), 1954-1957

Production Method 4

84163-42-8

Reaction Conditions

1.1 Reagents: Acetic anhydride Solvents: Chloroform ;  rt; 15 min, rt; rt → 5 °C
1.2 0 - 5 °C; 5 °C → 30 °C; 4 h, 30 °C
1.3 Reagents: Sodium bicarbonate Solvents: Water ;  30 min, 30 °C

Reference

Design and Straightforward Synthesis of Novel N-substituted 6-Fluoro-3-(piperidin-4-yl)-1,2-benzoxazole Derivatives and Their Antibacterial Activity

Garlapati, Krishna Kanth; Ganta, Ravi Kumar; Kumar, K. Siva; Srinivasu, N., Russian Journal of Organic Chemistry, 2023, 59(1), 190-195

Production Method 5

84163-42-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: 2,4,6-Trimethylpyridine ,  Tricyclohexylstannyl 1,1,1-trifluoromethanesulfonate Solvents: Sulfolane ;  24 h, 4 bar, 453 K

Reference

Tin-catalyzed reductive coupling of amines with CO2 and H2

Paparakis, Alexandros; Turnell-Ritson, Roland C.; Sapsford, Joshua S.; Ashley, Andrew E.; Hulla, Martin, Catalysis Science & Technology, 2023, 13(3), 637-644

Production Method 6

84163-42-8

Reaction Conditions

1.1 Reagents: Acetic anhydride ;  13 - 14 h, 10 - 15 °C
1.2 Solvents: Isopropanol ;  2 h, 0 - 5 °C

Reference

Synthesis of related substances of antipsychotic drug Risperidone

Gupta, Poonam, Pharma Innovation, 2021, 10(11), 99-104

Production Method 7

84163-42-8

Reaction Conditions

1.1 Reagents: Acetic anhydride Solvents: Isopropanol ;  14 h, 0 - 5 °C

Reference

Synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole amino acid derivatives and anti-DNA damaging activity

Ranganatha, S. R.; Vinaya, K.; Chandrappa, S.; Kumar, C. S. Ananda; Prasad, B. Benaka; et al, International Journal of Drug Design and Discovery, 2010, 1(1), 57-64

Production Method 8

2258-42-6

84163-42-8

Reaction Conditions

Reference

Synthesis and neuroleptic activity of 3-(1-substituted-4-piperidinyl)-1,2-benzisoxazoles

Strupczewski, Joseph T.; Allen, Richard C.; Gardner, Beth Ann; Schmid, Blaine L.; Stache, Ulrich; et al, Journal of Medicinal Chemistry, 1985, 28(6), 761-9

1-Formylpiperidine-4-carboxylic Acid Raw materials

• O-Formyl Acetate (Technical Grade)
• Formic acid, ion(1-)(8CI,9CI)

1-Formylpiperidine-4-carboxylic Acid Preparation Products

• 1-Formylpiperidine-4-carboxylic Acid (84163-42-8)

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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidinecarboxylic acids and derivatives Piperidinecarboxylic acids
• Other Chemical Reagents

• 111333-92-7(4-Piperidinecarboxylic acid, 1-(1-oxohexadecyl)-)
• 67659-33-0(4-Piperidinecarboxylic acid, 1-formyl-, (+)- (9CI))
• 926238-85-9(1-(3-Methylbutanoyl)piperidine-4-carboxylic acid)
• 225240-67-5(4-Piperidinecarboxylicacid, 1-acetyl-4-methyl-)
• 496057-38-6(3-Piperidinecarboxylic acid, 1-formyl- (9CI))
• 117705-17-6(1-Propionylpiperidine-4-carboxylic acid)
• 25503-90-6(1-Acetylpiperidine-4-carboxylic acid)
• 1226595-07-8(1-(1-acetylpiperidin-4-yl)cyclopropane-1-carboxylic acid)
• 67659-34-1(4-Piperidinecarboxylic acid, 1-formyl-, (-)- (9CI))
• 1000932-09-1(1-methyl-2-oxo-piperidine-4-carboxylic acid)