Production Method 1

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  15 min, rt; 30 min, rt
1.2 Solvents: tert-Butyl methyl ether ;  10 min, rt; rt → 0 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  15 min, 0 °C
1.4 Reagents: Sodium chloride Solvents: Water ;  5 min, 0 °C

Reference

Selective Dehydrocoupling of Phosphines by Lithium Chloride Carbenoids

Molitor, Sebastian; Becker, Julia; Gessner, Viktoria H., Journal of the American Chemical Society, 2014, 136(44), 15517-15520

Production Method 2

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  rt; 0.5 - 16 h, 35 °C
1.2 Reagents: Sodium hydroxide Solvents: tert-Butyl methyl ether ,  Water ;  35 °C; 35 °C → 0 °C; 15 min, 0 °C

Reference

Facile, Catalytic Dehydrocoupling of Phosphines Using β-Diketiminate Iron(II) Complexes

King, Andrew K.; Buchard, Antoine; Mahon, Mary F.; Webster, Ruth L., Chemistry - A European Journal, 2015, 21(45), 15960-15963

Production Method 3

1069-08-5

13139-86-1

84127-04-8

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran
1.2 Reagents: Hydrochloric acid Solvents: Hexane
1.3 Solvents: Diethyl ether

Reference

Electrophilic Trifluoromethylation - Approaches with Hypervalent Iodine Compounds

Kieltsch, Iris, 2008, , ,

Production Method 4

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Triethylamine ,  Trichlorosilane Solvents: Xylene ;  rt; 100 °C; reflux

Reference

Electronic and steric effects of ligands as control elements for rhodium-catalyzed asymmetric hydrogenation

Herseczki, Zsanett; Gergely, Ildiko; Hegedues, Csaba; Szoellosy, Aron; Bakos, Jozsef, Tetrahedron: Asymmetry, 2004, 15(11), 1673-1676

Production Method 5

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Pinacolborane Solvents: Acetonitrile ;  20 h, 60 °C
1.2 Reagents: Isopropanol

Reference

Rapid Metal-Free Formation of Free Phosphines from Phosphine Oxides

Provis-Evans, Cei B.; Emanuelsson, Emma A. C.; Webster, Ruth L., Advanced Synthesis & Catalysis, 2018, 360(20), 3999-4004

Production Method 6

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ;  40 min, 25 °C
1.2 Solvents: tert-Butyl methyl ether ;  10 min, rt; 10 min, rt; 10 min, rt; rt → 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  20 min

Reference

A Superior Method for the Reduction of Secondary Phosphine Oxides

Busacca, Carl A.; Lorenz, Jon C.; Grinberg, Nelu; Haddad, Nizar; Hrapchak, Matt; et al, Organic Letters, 2005, 7(19), 4277-4280

Production Method 7

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Toluene ,  Tetrahydrofuran ;  10 min, rt; 2 h, rt
1.2 Solvents: tert-Butyl methyl ether ;  5 min, rt; 10 min, rt; rt → 5 °C
1.3 Reagents: Sodium hydroxide Solvents: Water ;  10 min, 5 °C

Reference

Copper-catalyzed C-P cross-coupling of secondary phosphines with (hetero)aromatic bromide

Li, Chun-Jing; Lu, Jing; Zhang, Zhi-Xun; Zhou, Kun; Li, Yan; et al, Research on Chemical Intermediates, 2018, 44(7), 4547-4562

Production Method 8

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  15 min, rt; 3 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  15 min, 0 °C; 5 min, 0 °C

Reference

Tailored Cobalt-Catalysts for Reductive Alkylation of Anilines with Carboxylic Acids under Mild Conditions

Liu, Weiping; Sahoo, Basudev; Spannenberg, Anke; Junge, Kathrin; Beller, Matthias, Angewandte Chemie, 2018, 57(36), 11673-11677

Production Method 9

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Diisobutylaluminum hydride Solvents: Tetrahydrofuran ,  Hexane ;  15 min, rt; 4 h, rt
1.2 Reagents: Sodium hydroxide Solvents: Diethyl ether ,  Water ;  15 min, 0 °C; 5 min, rt

Reference

Manganese catalyzed urea and polyurea synthesis using methanol as C1 source

Guo, Jiaxin; Tang, Jun; Xi, Hui; Zhao, Sheng-Yin; Liu, Weiping, Chinese Chemical Letters, 2023, 34(4),

Production Method 10

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Pinacolborane Solvents: Acetonitrile ;  20 h, 60 °C

Reference

Hydrogen/Halogen Exchange of Phosphines for the Rapid Formation of Cyclopolyphosphines

Barrett, Adam N.; Woof, Callum R.; Goult, Christopher A.; Gasperini, Danila; Mahon, Mary F.; et al, Inorganic Chemistry, 2021, 60(21), 16826-16833

Production Method 11

15754-51-5

84127-04-8

Reaction Conditions

1.1 Reagents: Phenylsilane Catalysts: Borinic acid, B,B-bis(2-chlorophenyl)- Solvents: Toluene ;  18 h, 80 °C

Reference

Metal-free reduction of phosphine oxides, sulfoxides, and N-oxides with hydrosilanes using a borinic acid precatalyst

Chardon, Aurelien; Maubert, Orianne; Rouden, Jacques; Blanchet, Jerome, ChemCatChem, 2017, 9(24), 4460-4464

Bis(4-methoxyphenyl)phosphine Raw materials

• Bis(4-methoxyphenyl)phosphine oxide
• Diethylphosphoramidous Dichloride
• 4-Methoxyphenylmagnesium Bromide (0.5M in THF)

Bis(4-methoxyphenyl)phosphine Preparation Products

• Bis(4-methoxyphenyl)phosphine (84127-04-8)

• 1. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

• 14180-51-9(BIS(4-METHOXYPHENYL)PHENYLPHOSPHINE)
• 88257-54-9(Phosphonium, (3-methoxyphenyl)triphenyl-, iodide)
• 29949-84-6(Tris(m-methoxyphenyl)phosphine)
• 10177-79-4(Phosphine,bis(2-methoxyphenyl)-)
• 10111-20-3(Phosphonium, (4-methoxyphenyl)triphenyl-, bromide)
• 855-38-9(Tris(4-methoxyphenyl)phosphine)
• 92025-78-0(Phosphine, (2-methoxyphenyl)phenyl-)
• 74039-80-8(Mercury,dichlorobis[tris(4-methoxyphenyl)phosphine-P]-, (T-4)- (9CI))
• 896-89-9(Phosphine,(4-methoxyphenyl)diphenyl-)
• 10111-25-8(Phosphonium, (4-methoxyphenyl)triphenyl-, iodide)