Production Method 1

84089-73-6

Reaction Conditions

1.1 Reagents: Sulfuryl chloride Catalysts: Benzoyl peroxide ;  7 - 8 h, reflux
2.1 Solvents: Pyridine ;  4 h, 0 - 5 °C
3.1 Reagents: Sodium iodide Catalysts: Tetraethylammonium bromide Solvents: Toluene ;  7 h, reflux

Reference

Synthesis of 1-Iodoethyl Isopropyl Carbonate

Du, Jingxing; et al, Jingxi Huagong Zhongjianti, 2003, 33(5), 30-31

Production Method 2

84089-73-6

Reaction Conditions

1.1 Reagents: Sulfuryl chloride Catalysts: Benzoyl peroxide ;  7.5 h, reflux
2.1 Reagents: Pyridine Solvents: Dichloromethane ;  20 min, 0 - 5 °C; 30 min, 0 - 5 °C
3.1 Reagents: Sodium iodide Catalysts: 18-Crown-6 Solvents: Benzene ;  12 h, reflux

Reference

An improved method for preparation of cefpodoxime proxetil

Rodriguez, Juan C.; et al, Farmaco, 2003, 58(5), 363-369

Production Method 3

50893-53-3

84089-73-6

Reaction Conditions

1.1 Reagents: Isopropanol ,  Pyridine Solvents: Dichloromethane
2.1 Reagents: Sodium iodide ,  18-Crown-6 Solvents: Benzene

Reference

Studies on orally active cephalosporin esters

Fujimoto, Koichi; et al, Journal of Antibiotics, 1987, 40(3), 370-84

Production Method 4

84089-73-6

Reaction Conditions

1.1 Reagents: Pyridine Solvents: Dichloromethane ;  cooled
1.2 < 0 °C; 20 h, < 0 °C
2.1 Reagents: Pyridine Solvents: Dichloromethane ;  < 0 °C; 30 min, rt
3.1 Reagents: Sodium iodide Catalysts: 18-Crown-6 Solvents: Toluene ;  4 h, 110 °C; 110 °C → 10 °C

Reference

Synthesis of cefpodoxime proxetil

Yao, Yuanhai; et al, Zhongguo Yiyao Gongye Zazhi, 2008, 39(2), 90-92

1-Iodoethyl isopropyl carbonate Raw materials

• 1-Chloroethyl Chloroformate

1-Iodoethyl isopropyl carbonate Preparation Products

• 1-Iodoethyl isopropyl carbonate (84089-73-6)

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