• 1. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277
• 2. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526
• 3. An all-solid-state imprinted polymer-based potentiometric sensor for determination of bisphenol S?
  Rongning Liang,Tanji Yin,Ruiqing Yao,Wei Qin RSC Adv., 2016,6, 73308-73312
• 4. An approach to asymmetric synthesis of β-aryl alanines by Pd(0)-catalyzed cross-coupling and cyanate-to-isocyanate rearrangement?
  Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
• 5. An aptasensor for the detection of ampicillin in milk using a personal glucose meter
  Xixi Li,Nanwei Zhu,Ruohan Li,Qinpu Zhang Anal. Methods, 2020,12, 3376-3381

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzyl alcohols

Comprehensive Guide to (4-amino-2-fluorophenyl)methanol (CAS No. 840501-15-7): Properties, Applications, and Market Insights

(4-amino-2-fluorophenyl)methanol (CAS No. 840501-15-7) is an important fluorinated aromatic compound widely used in pharmaceutical synthesis, agrochemicals, and specialty chemicals. This compound, featuring both an amino group and a fluorophenyl moiety, has gained significant attention due to its unique chemical properties and versatility in organic synthesis. With the growing demand for fluorinated building blocks in drug discovery, 840501-15-7 has become a key intermediate for researchers and manufacturers.

The molecular structure of (4-amino-2-fluorophenyl)methanol combines a fluorinated benzene ring with an amino group at the para position and a hydroxymethyl group. This specific arrangement contributes to its enhanced reactivity in nucleophilic substitution reactions, making it valuable for creating more complex molecules. Recent studies highlight its potential in developing novel pharmaceutical compounds, particularly in the field of central nervous system (CNS) drugs and anti-inflammatory agents.

In pharmaceutical applications, 840501-15-7 serves as a crucial intermediate for synthesizing various active pharmaceutical ingredients (APIs). Its fluorinated aromatic structure improves metabolic stability and bioavailability of resulting compounds, addressing one of the key challenges in modern drug development. The compound's versatility extends to material science, where it's used in creating advanced polymers with specific optical or electronic properties.

The global market for (4-amino-2-fluorophenyl)methanol has shown steady growth, driven by increasing R&D investments in fluorine chemistry and targeted drug delivery systems. Industry reports suggest particular demand from contract research organizations (CROs) and generic drug manufacturers. Recent advancements in green chemistry have also influenced production methods, with manufacturers exploring more sustainable synthesis routes for this valuable intermediate.

Quality control of 840501-15-7 typically involves advanced analytical techniques including HPLC, GC-MS, and NMR spectroscopy to ensure high purity levels required for pharmaceutical applications. Storage recommendations generally emphasize protection from moisture and light, with optimal conditions varying based on specific product formulations. Researchers working with this compound should consult recent literature for the latest safety data sheets and handling guidelines.

Emerging applications of (4-amino-2-fluorophenyl)methanol include its use in developing fluorescent probes for biological imaging and as a building block for metal-organic frameworks (MOFs). These cutting-edge applications demonstrate the compound's expanding role beyond traditional pharmaceutical synthesis. The fluorine atom's unique properties contribute to these advanced applications, offering researchers new tools for molecular design and material engineering.

For researchers sourcing 840501-15-7, it's essential to verify suppliers' certificates of analysis and GMP compliance when intended for pharmaceutical use. The market offers various grades, from research quantities to bulk pharmaceutical intermediates, with pricing influenced by purity levels and market dynamics. Recent supply chain developments have emphasized the importance of dual sourcing strategies for critical intermediates like this compound.

The scientific literature contains numerous references to (4-amino-2-fluorophenyl)methanol in patent applications and journal articles, particularly in contexts of kinase inhibitor development and PET tracer synthesis. These publications highlight the compound's role in addressing current challenges in precision medicine and diagnostic imaging. Researchers are encouraged to explore recent publications for the latest synthetic methodologies and application breakthroughs involving this versatile intermediate.

Environmental considerations for 840501-15-7 include proper waste management and adherence to regional chemical disposal regulations. While not classified as hazardous under standard protocols, responsible handling practices are recommended. The pharmaceutical industry's increasing focus on green chemistry principles has led to improved synthetic routes that reduce environmental impact while maintaining high yields of this valuable intermediate.

Future prospects for (4-amino-2-fluorophenyl)methanol appear promising, with anticipated growth in applications related to bioconjugation chemistry and targeted therapeutics. The compound's unique structural features position it well for emerging technologies in drug delivery systems and diagnostic agents. Industry analysts predict sustained demand as fluorine chemistry continues to play a pivotal role in advancing life sciences and advanced materials development.

• 221285-25-2((2-Amino-6-fluorophenyl)methanol)
• 84832-00-8((5-Amino-2-fluorophenyl)methanol)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)