Cas no 84025-81-0 ((2R)-2-(methoxymethyl)pyrrolidine)

(2R)-2-(Methoxymethyl)pyrrolidine is a chiral pyrrolidine derivative featuring a methoxymethyl substituent at the 2-position. This compound is valued for its role as a versatile building block in asymmetric synthesis, particularly in pharmaceutical and agrochemical applications. Its stereochemical purity (R-configuration) makes it useful for constructing enantioselective catalysts or ligands, enhancing reaction selectivity. The methoxymethyl group offers functionalization potential, enabling further derivatization while maintaining stability under typical reaction conditions. Its pyrrolidine core contributes to conformational rigidity, aiding in the design of bioactive molecules. The compound is typically handled under inert conditions due to its sensitivity to moisture and air. Suitable for research and industrial-scale applications requiring chiral amine intermediates.

(2R)-2-(methoxymethyl)pyrrolidine structure

84025-81-0 structure

Product Name:(2R)-2-(methoxymethyl)pyrrolidine

CAS No:84025-81-0

MF:C₆H₁₃NO

MW:115.173521757126

MDL:MFCD00066219

CID:90866

PubChem ID:671216

Update Time:2025-05-27

(2R)-2-(methoxymethyl)pyrrolidine Chemical and Physical Properties

Names and Identifiers

- (R)-2-(Methoxymethyl)pyrrolidine
- (R)-(-)-2-(Methoxymethyl)pyrrolidine
- O-Methyl-D-prolinol
- (2R)-2-(Methoxymethyl)-pyrrolidine
- (R)-2-Methoxymethylpyrrolidine
- (R)-2-Methoxymethyl-pyrrolidine
- D-Prolinol methyl ether
- (2R)-2-(methoxymethyl)pyrrolidine
- PYRROLIDINE, 2-(METHOXYMETHYL)-, (2R)-
- (2R)-2-(Methoxymethyl)-pyrrolidine
- PubChem8186
- H-D-PRO-OL(ME)
- 2-(R)-methoxymethylpyrrolidine
- 2beta-(Methoxymethyl)pyrrolidine
- CHPRFKYDQRKRRK-ZCFIWIBFSA-N
- (2r)-2-met
- (2R)-2-(Methoxymethyl)pyrrolidine (ACI)
- Pyrrolidine, 2-(methoxymethyl)-, (R)- (ZCI)
- (R)-2-(Methoxymethyl)pyrrolidin
- AKOS015851503
- EN300-314248
- (R)-(-)-2-(Methoxymethyl)pyrrolidine, 99%
- SY013140
- TS-01599
- MFCD00066219
- (2r)-2-methoxymethyl-pyrrolidine
- (R)-2-(Methoxymethyl)-pyrrolidine
- (R)-(-)-2-(Methoxymethyl)pyrrolidine, >=98.0% (sum of enantiomers, GC)
- 84025-81-0
- (R)-(+)-2-(METHOXYMETHYL)PYRROLIDINE
- AC-23478
- M1169
- SCHEMBL59330
- AM81456
- CS-W002305
- STR08865
- MDL： MFCD00066219
- Inchi： 1S/C6H13NO/c1-8-5-6-3-2-4-7-6/h6-7H,2-5H2,1H3/t6-/m1/s1
- InChI Key： CHPRFKYDQRKRRK-ZCFIWIBFSA-N
- SMILES： C([C@@H]1NCCC1)OC
- BRN： 4229755

Computed Properties

Exact Mass: 115.1
Monoisotopic Mass: 115.1
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 2
Heavy Atom Count: 8
Rotatable Bond Count: 2
Complexity: 65.5
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 1
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Surface Charge: 0
Tautomer Count: nothing
XLogP3: 0.2
Topological Polar Surface Area: 21.3

Experimental Properties

Color/Form: Yellow transparent liquid
Density: 0.932?g/mL?at 20?°C(lit.)
Boiling Point: 61-62 °C/40 mmHg
Flash Point: Fahrenheit: 113 ° f
Celsius: 45 ° c
Refractive Index: n20/D 1.446
PSA: 21.26000
LogP: 0.71360
Sensitiveness: Air Sensitive
Specific Rotation: -2.4 o (c=2% in benzene)
Optical Activity: [α]20/D ?2.4±0.3°, c =?2% in benzene
Solubility: (mg/m1)

(2R)-2-(methoxymethyl)pyrrolidine Security Information

Symbol:
Prompt：warning
Signal Word：Warning
Hazard Statement： H226,H315,H319,H335
Warning Statement： P261,P305+P351+P338
Hazardous Material transportation number：UN 1993C 3 / PGIII
WGK Germany：3
Hazard Category Code： 10-36/37/38
Safety Instruction： 26-36
FLUKA BRAND F CODES：3-10-34
Hazardous Material Identification：
HazardClass：3
PackingGroup：III
Storage Condition：2-8 °C

(2R)-2-(methoxymethyl)pyrrolidine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	75R0527-1g	(R)-2-Methoxymethyl-pyrrolidine	84025-81-0	97%	1g	407.06CNY	2021-05-07
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	75R0527-5g	(R)-2-Methoxymethyl-pyrrolidine	84025-81-0	97%	5g	1662.16CNY	2021-05-07
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	75R0527-25g	(R)-2-Methoxymethyl-pyrrolidine	84025-81-0	97%	25g	6648.65CNY	2021-05-07
JIE DA WEI （ SHANG HAI ） YI YAO KE JI FA ZHAN Co., Ltd.	75R0527-100g	(R)-2-Methoxymethyl-pyrrolidine	84025-81-0	97%	100g	21116.26CNY	2021-05-07
Fluorochem	154000-1g	R)-(+)-2-(Methoxymethyl)pyrrolidine	84025-81-0	98%	1g	￡88.00	2022-02-28
Fluorochem	154000-5g	R)-(+)-2-(Methoxymethyl)pyrrolidine	84025-81-0	98%	5g	￡369.00	2022-02-28
AstaTech	11152-1/G	(R)-2-METHOXYMETHYLPYRROLIDINE	84025-81-0	95%	1g	$70	2023-09-18
AstaTech	11152-5/G	(R)-2-METHOXYMETHYLPYRROLIDINE	84025-81-0	95%	5g	$240	2023-09-18
Chemenu	CM121331-5g	(R)-2-(Methoxymethyl)pyrrolidine	84025-81-0	97%	5g	$***	2023-05-29
Apollo Scientific	OR4616-1g	(2R)-2-(Methoxymethyl)pyrrolidine	84025-81-0	95%	1g	￡57.00	2023-09-02

(2R)-2-(methoxymethyl)pyrrolidine Production Method

Production Method 1

344-25-2

84025-81-0

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ; rt; 1 h, reflux
1.2 Reagents: Potassium hydroxide Solvents: Water ; 15 min, reflux
1.3 Reagents: Methyl formate ; 1 h, 0 °C; 2 h, 0 °C
1.4 Reagents: Sodium hydride Solvents: Tetrahydrofuran ; -60 °C; overnight, -60 °C → rt; 15 min, reflux
1.5 Reagents: Hydrochloric acid Solvents: Water
1.6 Reagents: Potassium hydroxide Solvents: Water ; rt; 5 h, reflux

Reference

Iterative assembly line synthesis of polypropionates with full stereocontrol

Bootwicha, Teerawut; et al, Nature Chemistry, 2017, 9(9), 896-902

(2R)-2-(methoxymethyl)pyrrolidine Raw materials

D-Proline

(2R)-2-(methoxymethyl)pyrrolidine Preparation Products

(2R)-2-(methoxymethyl)pyrrolidine (84025-81-0)

(2R)-2-(methoxymethyl)pyrrolidine Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:84025-81-0)(2R)-2-(methoxymethyl)pyrrolidine

Order Number:A864188

Stock Status:in Stock

Quantity:5g/25g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 08:45

Price ($):265.0/1322.0

Email:[email protected]

Product Official Link

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