Cas no 84006-10-0 (2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine)

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine is a versatile organic compound characterized by its distinct structural features. It offers a unique balance of chloromethyl and methoxy groups, which enhances its reactivity and solubility in organic solvents. This compound is well-suited for various synthetic applications, including heterocyclic compound synthesis and pharmaceutical research, due to its potential for forming stable chemical bonds.
2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine structure
84006-10-0 structure
Product Name:2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine
CAS No:84006-10-0
MF:C9H12ClNO
MW:185.650681495667
CID:60642
PubChem ID:819992
Update Time:2025-10-31

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Chemical and Physical Properties

Names and Identifiers

    • 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine
    • 2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridine
    • 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine hydrochloride
    • 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine (ACI)
    • 2-Chlormethyl-4-methoxy-3,5-dimethyl pyridine hydrochloride
    • 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine
    • 4-Methoxy-3,5-dimethyl-2-(chloromethyl)pyridine
    • METHYLBRASSIDATE
    • 2-chloromethyl-3,5-dimethyl-4-methoxy-pyridine
    • 2-chloromethyl-4-methoxy-3,5-dimethyl-pyridine
    • 2-chloromethyl-4-methoxy-3,5-dimethylpyridine
    • SCHEMBL1160150
    • NH3A66X6A6
    • AN-668/25055009
    • AKOS000321191
    • 3,5-dimethyl-4-methoxy-2-pyridylmethyl chloride
    • Pyridine, 2-(chloromethyl)-4-methoxy-3,5-dimethyl-
    • 3,5-dimethyl-4-methoxy-2-chloromethylpyridine
    • MFCD03265239
    • EN300-57759
    • BB 0262067
    • AS-75978
    • SRKVJDYNPSMHJM-UHFFFAOYSA-N
    • 2-(chloromethyl)-4-methoxy-3, 5-dimethylpyridine
    • 2-chloromethyl-4-methoxy-3,5-lutidine
    • SB53801
    • UNII-NH3A66X6A6
    • FT-0611964
    • DTXSID70356147
    • 84006-10-0
    • DB-031921
    • 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine; 2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine; 2-Chlormethyl-4-methoxy-3,5-dimethyl pyridine hydrochloride; 2-Chloromethyl-3,5-dimethyl-4-methoxypyridine; 4-Methoxy-3,5-dimethyl-2-(chloromethyl)pyridine
    • STK501313
    • ALBB-006039
    • DB-355965
    • DTXCID80307206
    • MDL： MFCD03265239
    • Inchi： 1S/C9H12ClNO/c1-6-5-11-8(4-10)7(2)9(6)12-3/h5H,4H2,1-3H3
    • InChI Key： SRKVJDYNPSMHJM-UHFFFAOYSA-N
    • SMILES： ClCC1C(C)=C(OC)C(C)=CN=1

Computed Properties

  • Exact Mass: 185.06100
  • Monoisotopic Mass: 185.061
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 2
  • Complexity: 143
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: 2
  • Topological Polar Surface Area: 22.1A^2

Experimental Properties

  • Density: 1.112
  • Boiling Point: 272.2°C at 760 mmHg
  • Flash Point: 118.4°C
  • PSA: 22.12000
  • LogP: 2.44580

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Security Information

  • Hazardous Material transportation number：UN3077 9/PG 3
  • Safety Instruction： S60-S61
  • RTECS：NJ5808500
  • Hazardous Material Identification： N
  • HazardClass：IRRITANT
  • Risk Phrases：R34

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Customs Data

  • HS CODE：2933399090
  • Customs Data：

    China Customs Code:

    2933399090

    Overview:

    2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Pricemore >>

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2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Triethylamine ,  Phosphorus oxychloride Solvents: Dichloromethane ;  1 h, reflux
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 10
Reference
Improvement on the synthesis of 2-chloromethyl-4-methoxy-3,5-dimethylpyridine
Ma, Nan; et al, Hecheng Huaxue, 2007, 15(3), 385-387

Production Method 2

Reaction Conditions
Reference
Product class 1: pyridines
Spitzner, D., Science of Synthesis, 2005, 15, 11-284

Production Method 3

Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Methanol ;  rt → -10 °C; 30 min, -20 - -10 °C; -20 - -10 °C; 3 h, -10 °C → rt; rt
Reference
Synthesis of omeprazole
Liu, Xiulan, Shanxi Yike Daxue Xuebao, 2002, 33(4), 330-332

Production Method 4

Reaction Conditions
1.1 Reagents: Sodium hydride Solvents: Dimethylformamide ;  2 h, 95 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  neutralized
2.1 Reagents: Acetic anhydride ;  2 h, 100 °C
2.2 Reagents: Sodium hydroxide Solvents: Water ;  1 h, rt
3.1 Reagents: Thionyl chloride ;  2 h, rt
3.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized
Reference
Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
Rafique, Waqas; et al, ACS Omega, 2018, 3(7), 7567-7579

Production Method 5

Reaction Conditions
Reference
Preparation of 2-(chloro- and hydroxymethyl)-3,5-dimethyl-4-methoxy pyridine
, European Patent Organization, , ,

Production Method 6

Reaction Conditions
1.1 Reagents: Sodium ;  5 h, reflux
2.1 Reagents: Triethylamine ,  Phosphorus oxychloride Solvents: Dichloromethane ;  1 h, reflux
2.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 10
Reference
Improvement on the synthesis of 2-chloromethyl-4-methoxy-3,5-dimethylpyridine
Ma, Nan; et al, Hecheng Huaxue, 2007, 15(3), 385-387

Production Method 7

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Methanol ;  rt → reflux; 1.5 h, reflux; 2 h, reflux
1.2 Reagents: Sulfuric acid ;  pH 9
2.1 Solvents: Methanol ;  15 min, rt
2.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 7; 1.5 h, reflux
2.3 1.5 h, reflux; overnight, rt
2.4 Reagents: Dithionous acid, ammonium salt (1:2) ;  2 h, reflux; overnight, rt
2.5 Reagents: Sodium hydroxide Solvents: Water ;  pH 10
3.1 Reagents: Thionyl chloride Solvents: Methanol ;  rt → -10 °C; 30 min, -20 - -10 °C; -20 - -10 °C; 3 h, -10 °C → rt; rt
Reference
Synthesis of omeprazole
Liu, Xiulan, Shanxi Yike Daxue Xuebao, 2002, 33(4), 330-332

Production Method 8

Reaction Conditions
1.1 Reagents: Thionyl chloride ;  2 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  neutralized
Reference
Image-Guided Development of Heterocyclic Sulfoxides as Ligands for Tau Neurofibrillary Tangles: From First-in-Man to Second-Generation Ligands
Rafique, Waqas; et al, ACS Omega, 2018, 3(7), 7567-7579

Production Method 9

Reaction Conditions
1.1 Reagents: Thionyl chloride Solvents: Dichloromethane ;  rt → 0 °C; 0 °C; 1 h, rt
1.2 Reagents: Sodium carbonate Solvents: Water
Reference
Preparation of pyridoimidazole derivatives for preventing and treating digestive tract ulcer
, China, , ,

Production Method 10

Reaction Conditions
1.1 Reagents: Potassium carbonate Solvents: Water ;  2 - 3 min, rt
Reference
EPR Spectroscopic Detection of the Elusive FeV=O Intermediates in Selective Catalytic Oxofunctionalizations of Hydrocarbons Mediated by Biomimetic Ferric Complexes
Lyakin, Oleg Y.; et al, ACS Catalysis, 2015, 5(5), 2702-2707

Production Method 11

Reaction Conditions
1.1 Reagents: Sodium hydroxide Solvents: Dichloromethane ,  Water ;  1 h, rt
Reference
Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis
Wood, Devin; et al, Angewandte Chemie, 2023, 62(15),

Production Method 12

Reaction Conditions
1.1 Reagents: Sodium carbonate Solvents: Water
Reference
Bioinspired symmetrical and unsymmetrical diiron complexes for selective oxidation catalysis with hydrogen peroxide
Trehoux, Alexandre; et al, Dalton Transactions, 2020, 49(46), 16657-16661

Production Method 13

Reaction Conditions
Reference
Product class 1: pyridines
Spitzner, D., Science of Synthesis, 2005, 15, 11-284

Production Method 14

Reaction Conditions
1.1 Solvents: Methanol ;  15 min, rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  pH 7; 1.5 h, reflux
1.3 1.5 h, reflux; overnight, rt
1.4 Reagents: Dithionous acid, ammonium salt (1:2) ;  2 h, reflux; overnight, rt
1.5 Reagents: Sodium hydroxide Solvents: Water ;  pH 10
2.1 Reagents: Thionyl chloride Solvents: Methanol ;  rt → -10 °C; 30 min, -20 - -10 °C; -20 - -10 °C; 3 h, -10 °C → rt; rt
Reference
Synthesis of omeprazole
Liu, Xiulan, Shanxi Yike Daxue Xuebao, 2002, 33(4), 330-332

Production Method 15

Reaction Conditions
Reference
Preparation of 2-(chloro- and hydroxymethyl)-3,5-dimethyl-4-methoxy pyridine
, European Patent Organization, , ,

Production Method 16

Reaction Conditions
1.1 -
2.1 Reagents: Acetic anhydride ,  Sodium hydroxide
3.1 Reagents: Thionyl chloride Solvents: Dichloromethane
Reference
(H+, K+)-ATPase inhibiting 2-[(2-pyridylmethyl)sulfinyl]benzimidazoles. 4. A novel series of dimethoxypyridyl-substituted inhibitors with enhanced selectivity. The selection of pantoprazole as a clinical candidate
Kohl, Bernhard; et al, Journal of Medicinal Chemistry, 1992, 35(6), 1049-57

2-(Chloromethyl)-4-methoxy-3,5-dimethylpyridine Raw materials

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Amadis Chemical Company Limited
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(CAS:84006-10-0)2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine
Order Number:A10113
Stock Status:in Stock
Quantity:5g
Purity:99%
Pricing Information Last Updated:Thursday, 29 August 2024 15:11
Price ($):340.0
Suzhou Senfeida Chemical Co., Ltd
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(CAS:84006-10-0)2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridine
Order Number:sfd595
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

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Amadis Chemical Company Limited
(CAS:84006-10-0)2-(chloromethyl)-4-methoxy-3,5-dimethylpyridine
A10113
Purity:99%
Quantity:5g
Price ($):340.0
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Suzhou Senfeida Chemical Co., Ltd
(CAS:84006-10-0)2-(Chloromethyl)-3,5-dimethyl-4-methoxypyridine
sfd595
Purity:99.9%
Quantity:200kg
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