Production Method 1

83846-85-9

Reaction Conditions

1.1 Reagents: Diboronic acid Solvents: Toluene ;  8 h, 100 °C

Reference

Catalyst- and additive-free chemoselective reduction of sulfoxides into sulfides using B2(OH)4 as a deoxygenative agent

Fan, Jixia; et al, Tetrahedron, 2023, 140,

Production Method 2

83846-85-9

Reaction Conditions

1.1 Reagents: μ-Chlorobis(η5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-μ-methylenetitanium Solvents: Toluene ,  Tetrahydrofuran
1.2 Reagents: Sodium hydroxide Solvents: Water

Reference

Novel reactions initiated by titanocene methylidenes: deoxygenation of sulfoxides, N-oxides, and selenoxides

Nicolaou, K. C.; et al, Angewandte Chemie, 2000, 39(14), 2529-2533

Production Method 3

134-85-0

83846-85-9

Reaction Conditions

1.1 Reagents: Tripotassium phosphate Solvents: 1-Methyl-3-octylimidazolium bromide ;  24 h, 120 °C

Reference

Facile aromatic nucleophilic substitution (SNAr) reactions in ionic liquids: an electrophile-nucleophile dual activation by [Omim]Br for the reaction

Zhang, Xiao; et al, Green Chemistry, 2016, 18(20), 5580-5585

Production Method 4

824-79-3

90-90-4

83846-85-9

Reaction Conditions

1.1 Reagents: Lithium perchlorate Catalysts: 4,4′-Dimethoxy-2,2′-bipyridine ,  Nickel(2+), tetrakis(pyridine)-, chloride (1:2), (SP-4-1)- Solvents: Dimethyl sulfoxide ;  16 h, 26 °C

Reference

Paired Electrolysis Enabled Ni-Catalyzed Unconventional Cascade Reductive Thiolation Using Sulfinates

Kang, Jun-Chen; et al, Journal of Organic Chemistry, 2021, 86(21), 15326-15334

Production Method 5

824-79-3

90-90-4

83846-85-9

Reaction Conditions

1.1 Reagents: Lithium bromide ,  Water Catalysts: Dichloro[1,2-di(methoxy-κO)ethane]nickel ,  4,4′-Bis(1,1-dimethylethyl)-2,2′-bipyridine ,  Iridium(1+), [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-κN1,κN1′]bis[3,5-diflu… Solvents: Dimethylformamide ;  36 h, 25 - 30 °C

Reference

Deoxygenative C-S Bond Coupling with Sulfinates via Nickel/Photoredox Dual Catalysis

Zhong, Shuai; et al, Organic Letters, 2022, 24(9), 1865-1870

Production Method 6

268218-94-6

83846-85-9

Reaction Conditions

1.1 Reagents: 2,2′-Bipyridine ,  Potassium tert-butoxide Catalysts: Nickel dichloride Solvents: Dimethylformamide ,  Acetonitrile ;  5 min, rt; 12 h, rt
1.2 Reagents: Ammonium chloride Solvents: Water

Reference

Electrochemically Enabled Sulfoximido-Oxygenation of Alkenes with NH-Sulfoximines and Alcohols

Wan, Jin-Lin; et al, Organic Letters, 2022, 24(48), 8914-8919

Production Method 7

611-95-0

83846-85-9

Reaction Conditions

1.1 Reagents: Pivalic anhydride Catalysts: Bis(1,5-cyclooctadiene)nickel ,  1,3-Bis(diphenylphosphino)propane Solvents: Acetonitrile ;  12 h, 140 °C; 140 °C → rt
1.2 Reagents: Water ;  rt

Reference

Nickel-Catalyzed Decarbonylative Thioetherification of Carboxylic Acids with Thiols

Xu, Tianhao; et al, Journal of Organic Chemistry, 2022, 87(13), 8672-8684

Production Method 8

83846-85-9

Reaction Conditions

1.1 Reagents: μ-Chlorobis(η5-2,4-cyclopentadien-1-yl)(dimethylaluminum)-μ-methylenetitanium ;  1 h

Reference

μ-Chlorobis(cyclopentadienyl) (dimethylaluminum)-μ-methylenetitanium

Straus, Daniel A.; et al, e-EROS Encyclopedia of Reagents for Organic Synthesis, 2006, 1, 1-12

Production Method 9

90-90-4

83846-85-9

Reaction Conditions

1.1 Reagents: Cesium carbonate Solvents: Dimethyl sulfoxide ;  1 h, 25 °C

Reference

Visible-Light-Promoted C-S Cross-Coupling via Intermolecular Charge Transfer

Liu, Bin; et al, Journal of the American Chemical Society, 2017, 139(39), 13616-13619

Production Method 10

134-85-0

10486-08-5

83846-85-9

Reaction Conditions

1.1 Catalysts: Hexaethylguanidinium bromide Solvents: 1,2-Dichlorobenzene ,  Chlorobenzene

Reference

Method for conducting organic reactions using guanidinium salt as phase transfer catalyst

, Canada, , ,

Production Method 11

83846-85-9

Reaction Conditions

1.1 Catalysts: 1,3-Bis(diphenylphosphino)propane ,  Dichloro[1,2-di(methoxy-κO)ethane]nickel Solvents: Toluene ;  30 s, rt
1.2 Reagents: Sodium carbonate Solvents: Toluene ;  24 h, 140 °C; 140 °C → rt
1.3 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Nickel-Catalyzed Decarbonylative Thioetherification of Acyl Fluorides via C-F Bond Activation

You, Jingwen; et al, Synthesis, 2021, 53(17), 3045-3050

Production Method 12

37991-79-0

83846-85-9

Reaction Conditions

1.1 Reagents: Sodium carbonate ,  Magnesium Catalysts: 1,3-Bis(diphenylphosphino)propane ,  Nickel dichloride Solvents: Toluene ;  36 h, rt → 150 °C

Reference

Nickel-Catalyzed C-S Bond Formation via Decarbonylative Thioetherification of Esters, Amides and Intramolecular Recombination Fragment Coupling of Thioesters

Lee, Shao-Chi; et al, Chemistry - A European Journal, 2018, 24(14), 3608-3612

Production Method 13

6136-66-9

83846-85-9

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Dimethyl sulfoxide ;  30 min, rt
1.2 Reagents: Potassium methoxide ,  Bis(pinacolato)diborane Catalysts: 4-Phenylpyridine ;  25 °C; 24 h, 25 °C

Reference

Coupling of thiols and aromatic halides promoted by diboron derived super electron donors

Franco, Mario; et al, Chemical Communications (Cambridge, 2021, 57(88), 11653-11656

Production Method 14

95523-79-8

10371-42-3

83846-85-9

2005-08-5

Reaction Conditions

1.1 Catalysts: 1,2-Bis(diphenylphosphino)ethane ,  Hydrotetrakis(triphenylphosphine)rhodium Solvents: Chlorobenzene ;  5 h, reflux

Reference

Rhodium-Catalyzed Synthesis of Unsymmetric Di(heteroaryl) Sulfides Using Heteroaryl Ethers and S-Heteroaryl Thioesters via Heteroarylthio Exchange

Arisawa, Mieko; et al, Journal of Organic Chemistry, 2017, 82(1), 804-810

4-Benzoyl-4'-methyldiphenyl Sulfide Raw materials

• 4-Iodobenzophenone
• 4-Chlorobenzophenone
• Sodium toluene-4-sulphinate
• Methanone, [4-(4-chlorophenoxy)phenyl]phenyl-
• 4-Benzoylbenzoic acid
• 4-Bromobenzophenone
• Benzenecarbothioicacid, S-(4-methylphenyl) ester
• Benzenethiol,4-methyl-, sodium salt (1:1)
• (4-benzoylphenyl)boronic acid
• Phenyl 4-(benzoyl)benzoate

4-Benzoyl-4'-methyldiphenyl Sulfide Preparation Products

• 4-Benzoyl-4'-methyldiphenyl Sulfide (83846-85-9)
• 4-Chlorophenyl benzoate (2005-08-5)

• 1. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 4. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 5. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207

• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Comprehensive Overview of 4-Benzoyl-4'-methyldiphenyl Sulfide (CAS No. 83846-85-9): Properties, Applications, and Industry Insights

4-Benzoyl-4'-methyldiphenyl Sulfide (CAS No. 83846-85-9) is a specialized organic compound gaining attention in advanced material science and fine chemical synthesis. This diphenyl sulfide derivative features a benzoyl group at the 4-position and a methyl group at the 4'-position, creating a unique molecular architecture that enables diverse applications. Researchers and manufacturers are increasingly exploring its potential due to its balanced photochemical stability and structural versatility, particularly in polymer additives and specialty coatings.

The compound's molecular structure (C₂₀H₁₆OS) combines aromatic rings with a sulfide bridge, offering both thermal resistance and electronic delocalization properties. These characteristics make it valuable for developing high-performance materials, a trending topic in sustainable technology forums. Recent studies highlight its role in UV-absorbing formulations, addressing growing demand for light-stable materials in automotive and construction industries.

From a synthesis perspective, 4-Benzoyl-4'-methyldiphenyl Sulfide is typically produced through Friedel-Crafts acylation of 4-methyldiphenyl sulfide, followed by purification via recrystallization. The process optimization has become a frequent search query among organic chemists, reflecting industry's focus on green chemistry principles and atom economy. Analytical characterization using HPLC, NMR, and mass spectrometry confirms its high purity (>98%), a critical parameter for research-grade applications.

In material science applications, this compound demonstrates exceptional performance as a photoinitiator synergist in UV-curable resins. This aligns with current market trends toward energy-efficient curing technologies and low-VOC formulations. Its ability to enhance polymer crosslinking efficiency while maintaining clarity makes it particularly valuable for optical coatings and adhesives - topics frequently discussed in advanced manufacturing webinars.

The structure-activity relationship of CAS 83846-85-9 has attracted computational chemistry interest, with molecular modeling studies predicting its electronic transitions and radical stabilization capabilities. These computational approaches, combined with experimental data, help optimize its use in electronic materials - a hot topic in flexible electronics research. The compound's charge transport properties are being evaluated for potential organic semiconductor applications.

Storage and handling recommendations for 4-Benzoyl-4'-methyldiphenyl Sulfide emphasize protection from moisture and oxidation, with inert atmosphere packaging being industry standard. Quality control protocols typically include melting point verification (126-128°C) and chromatographic purity analysis, reflecting pharmaceutical-grade standards even for industrial applications. These procedures address common purchaser concerns about batch-to-batch consistency in fine chemicals.

Emerging research explores the compound's potential in advanced battery technologies, particularly as a cathode interface modifier in lithium-ion systems. This application capitalizes on its redox stability and surface adsorption properties, topics gaining traction in energy storage conferences. Such developments position 83846-85-9 as a multi-functional chemical bridging materials science and energy innovation.

From a commercial availability standpoint, 4-Benzoyl-4'-methyldiphenyl Sulfide is offered in research quantities by specialty chemical suppliers, with pricing reflecting its high-purity synthesis requirements. Procurement specialists frequently search for bulk pricing tiers and custom synthesis options, indicating growing industrial adoption. The compound's REACH compliance status and regulatory documentation availability are additional common inquiries from quality assurance professionals.

Future development directions for this chemical include exploration as a ligand precursor in catalytic systems and investigations into its biological activity profiles. These research avenues respond to the chemical industry's dual focus on process catalysis efficiency and bioactive material discovery. The compound's structural features suggest potential in both domains, making it a subject of ongoing patent activity.

In summary, 4-Benzoyl-4'-methyldiphenyl Sulfide (CAS 83846-85-9) represents a versatile building block with expanding applications across high-tech industries. Its combination of aromatic stability, functional group diversity, and process compatibility addresses multiple contemporary challenges in material development. As research continues to uncover new applications, this compound is poised to play an increasingly important role in advanced material formulations and specialty chemical solutions.

• 63084-99-1(4,4’-Bis-(methylthio)-benzophenone)
• 26960-79-2(Methanone,phenyl[4-[(phenylmethyl)thio]phenyl]-)
• 1441-99-2(1-3-(methylsulfanyl)phenylethan-1-one)
• 10169-55-8(4-Acetyldiphenyl Sulfide)
• 1778-09-2(1-[4-(methylsulfanyl)phenyl]ethan-1-one)
• 73242-05-4(4-tert-Butyl-4'-(thiomethyl)benzophenone)
• 23405-48-3(Methanone, [4-(methylthio)phenyl]phenyl-)
• 2615-09-0(di-acetodiphenylmonosulfide)
• 143022-80-4(Methanone, [1,4-phenylenebis(thio-4,1-phenylene)]bis[phenyl-)
• 167406-93-1(Methanone, (thiodi-4,1-phenylene)bis[(3-methylphenyl)-)