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Comprehensive Overview of β-D-Glucopyranose 1-Phosphate Disodium Salt (CAS No. 83833-15-2): Properties, Applications, and Research Insights

β-D-Glucopyranose 1-Phosphate Disodium Salt (CAS No. 83833-15-2) is a biologically significant carbohydrate derivative widely utilized in biochemical research, enzymatic studies, and pharmaceutical development. This compound, often referred to as glucose-1-phosphate disodium salt, serves as a critical intermediate in glycogen metabolism and carbohydrate synthesis pathways. Its molecular structure features a β-D-glucopyranose moiety linked to a phosphate group at the C1 position, stabilized by disodium ions for enhanced solubility and stability.

In recent years, the demand for β-D-Glucopyranose 1-Phosphate has surged due to its role in glycosylation reactions, a hotspot in glycobiology research. Scientists are increasingly exploring its applications in enzyme kinetics, particularly for glycogen phosphorylase and UDP-glucose pyrophosphorylase assays. The compound's relevance extends to metabolic disorder studies, aligning with growing public interest in diabetes and glycogen storage diseases (GSDs).

From a technical perspective, CAS 83833-15-2 exhibits high purity (>98%) and water solubility, making it ideal for in vitro experiments. Researchers frequently employ it in NMR spectroscopy and mass spectrometry to trace carbohydrate metabolic fluxes. Notably, its stability under physiological pH conditions (6.0-8.0) has spurred investigations into drug delivery systems, where it acts as a biocompatible carrier for targeted therapies.

The compound's mechanism of action involves serving as a substrate for glycosyltransferases, enzymes crucial for post-translational modifications. This property has attracted attention in biopharmaceutical production, especially for monoclonal antibody glycosylation optimization – a trending topic in bioprocessing forums. Industrial applications include its use in diagnostic kit formulations for detecting inherited metabolic diseases.

Emerging studies highlight β-D-Glucopyranose 1-Phosphate Disodium Salt's potential in prebiotic chemistry research, addressing fundamental questions about life's chemical origins. Its compatibility with high-throughput screening platforms has positioned it as a valuable tool for drug discovery pipelines targeting carbohydrate-active enzymes. Furthermore, the compound's role in starch biosynthesis pathways makes it relevant to agricultural biotechnology innovations.

Quality control of 83833-15-2 typically involves HPLC analysis and enzymatic activity assays to ensure batch-to-batch consistency. Storage recommendations include protection from moisture at -20°C, with shelf-life extension achievable through lyophilization. These practical considerations are frequently searched by laboratory technicians and procurement specialists.

Recent patent analyses reveal growing intellectual property activity around glucose-1-phosphate derivatives, particularly in biocatalysis and green chemistry applications. The compound's natural origin and biodegradability align with the sustainable chemistry movement, answering market demands for eco-friendly reagents.

From a commercial perspective, β-D-Glucopyranose 1-Phosphate Disodium Salt is available in various packaging formats (10mg-1kg) to accommodate academic and industrial needs. Pricing trends reflect increasing adoption in personalized medicine research, particularly for rare disease therapeutic development. Current Good Manufacturing Practice (cGMP) grade options are emerging to meet clinical trial material requirements.

Future research directions may explore this compound's utility in synthetic biology platforms for cell-free systems and artificial metabolic pathways. Its fundamental role in energy metabolism continues to inspire investigations into bioenergetics and mitochondrial disorders – areas receiving substantial NIH funding and public health attention.

• 27251-84-9(D-Mannopyranose,1-(dihydrogen phosphate))
• 2255-14-3(a-D-Galactopyranose, 1-(dihydrogenphosphate))
• 374726-44-0(L-Fucose-1-phosphate disodium salt)
• 305-58-8(a-D-Glucopyranose,1,6-bis(dihydrogen phosphate))
• 16562-59-7(6-deoxy-beta-L-galactopyranose 1-(dihydrogen phosphate))
• 19504-70-2(a-D-Mannopyranose,1,6-bis(dihydrogen phosphate))
• 150399-99-8(a-D-Glucose-1-phosphate Disodium Salt Tetrahydrate)
• 56401-20-8(a-D-Glucose 1-Phosphate Disodium Salt Tetrahydrate)
• 16562-58-6(L-Galactopyranose,6-deoxy-, 1-(dihydrogen phosphate))
• 10139-18-1(a-D-Glucopyranose,1,6-bis(dihydrogen phosphate))