Cas no 837364-98-4 (4,6-Difluoro-2-hydrazono-2,3-dihydropyridine)

4,6-Difluoro-2-hydrazono-2,3-dihydropyridine structure
837364-98-4 structure
Product Name:4,6-Difluoro-2-hydrazono-2,3-dihydropyridine
CAS No:837364-98-4
MF:C5H5F2N3
MW:145.110107183456
MDL:MFCD27665424
CID:716199
PubChem ID:72206661
Update Time:2024-10-26

4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Chemical and Physical Properties

Names and Identifiers

    • 4,6-Difluoro-2-hydrazono-2,3-dihydropyridine
    • (4,6-difluoro-pyridin-2-yl)-hydrazine
    • (4,6-difluoropyridin-2-yl)hydrazine
    • Pyridine,2,4-difluoro-6-hydrazinyl-
    • 2,4-difluoro-6-hydrazinopyridine
    • 4,6-difluoro-2-hydrazinopyridine
    • Pyridine,2,4-difluoro-6-hydrazinyl
    • 2(1H)-Pyridinone, 4,6-difluoro-, hydrazone (9CI)
    • 2,4-Difluoro-6-hydrazinylpyridine
    • AKOS022175561
    • DS-3081
    • 837364-98-4
    • (E)-(4,6-difluoro-3H-pyridin-2-ylidene)hydrazine
    • (2E)-4,6-difluoro-2-hydrazinylidene-2,3-dihydropyridine
    • MDL： MFCD27665424
    • Inchi： 1S/C5H5F2N3/c6-3-1-4(7)9-5(2-3)10-8/h1-2H,8H2,(H,9,10)
    • InChI Key： QAOLSEWSDLEITH-UHFFFAOYSA-N
    • SMILES： FC1=CC(=NN)NC(F)=C1

Computed Properties

  • Exact Mass: 145.04500
  • Monoisotopic Mass: 145.04515350g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 3
  • Heavy Atom Count: 10
  • Rotatable Bond Count: 1
  • Complexity: 229
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 1
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.1
  • Topological Polar Surface Area: 50.7?2

Experimental Properties

  • PSA: 50.94000
  • LogP: 1.41870

4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Security Information

  • Storage Condition：Sealed in dry,2-8°C

4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Customs Data

  • HS CODE：2933990090
  • Customs Data：

    China Customs Code:

    2933990090

    Overview:

    2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution
Bobbio, Carla; et al, Chemistry - A European Journal, 2005, 11(6), 1903-1910

Production Method 2

Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  45 min, -100 °C
1.2 45 min, -75 °C
2.1 Reagents: Hydrazine Solvents: Tetrahydrofuran ;  2 h, 50 °C
3.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: the trialkylsilyl trick
Schlosser, Manfred; et al, Journal of Organic Chemistry, 2005, 70(7), 2494-2502

Production Method 3

Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  45 min, -100 °C
1.2 1 h, -75 °C
2.1 Reagents: Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ;  2 h, 50 °C
3.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution
Bobbio, Carla; et al, Chemistry - A European Journal, 2005, 11(6), 1903-1910

Production Method 4

Reaction Conditions
1.1 Reagents: Ammonium formate Catalysts: Palladium Solvents: 1-Octanol ;  6 h, 25 °C
2.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  45 min, -100 °C
2.2 1 h, -75 °C
3.1 Reagents: Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ;  2 h, 50 °C
4.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution
Bobbio, Carla; et al, Chemistry - A European Journal, 2005, 11(6), 1903-1910

Production Method 5

Reaction Conditions
1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: the trialkylsilyl trick
Schlosser, Manfred; et al, Journal of Organic Chemistry, 2005, 70(7), 2494-2502

Production Method 6

Reaction Conditions
1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Rerouting Nucleophilic Substitution from the 4-Position to the 2- or 6-Position of 2,4-Dihalopyridines and 2,4,6-Trihalopyridines: The Solution to a Long-Standing Problem
Schlosser, Manfred; et al, Organic Letters, 2005, 7(1), 127-129

Production Method 7

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Tetrahydrofuran ;  2 h, 50 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Regiochemically flexible substitutions of di-, tri-, and tetrahalopyridines: the trialkylsilyl trick
Schlosser, Manfred; et al, Journal of Organic Chemistry, 2005, 70(7), 2494-2502

Production Method 8

Reaction Conditions
1.1 Reagents: Hydrazine hydrate (1:1) Solvents: Tetrahydrofuran ;  2 h, 50 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Removal of fluorine from and introduction of fluorine into polyhalopyridines: an exercise in nucleophilic hetarenic substitution
Bobbio, Carla; et al, Chemistry - A European Journal, 2005, 11(6), 1903-1910

Production Method 9

Reaction Conditions
1.1 Reagents: Hydrazine Solvents: Tetrahydrofuran ;  2 h, 50 °C
2.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Rerouting Nucleophilic Substitution from the 4-Position to the 2- or 6-Position of 2,4-Dihalopyridines and 2,4,6-Trihalopyridines: The Solution to a Long-Standing Problem
Schlosser, Manfred; et al, Organic Letters, 2005, 7(1), 127-129

Production Method 10

Reaction Conditions
1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  45 min, -100 °C
1.2 -100 °C → -75 °C; 45 min, -75 °C
1.3 Solvents: Water
2.1 Reagents: Hydrazine Solvents: Tetrahydrofuran ;  2 h, 50 °C
3.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  2 h, 25 °C
Reference
Rerouting Nucleophilic Substitution from the 4-Position to the 2- or 6-Position of 2,4-Dihalopyridines and 2,4,6-Trihalopyridines: The Solution to a Long-Standing Problem
Schlosser, Manfred; et al, Organic Letters, 2005, 7(1), 127-129

4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Raw materials

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4,6-Difluoro-2-hydrazono-2,3-dihydropyridine Suppliers

Amadis Chemical Company Limited
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Audited Supplier Audited Supplier
(CAS:837364-98-4)4,6-Difluoro-2-hydrazono-2,3-dihydropyridine
Order Number:A864226
Stock Status:in Stock
Quantity:250mg/1g/5g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 08:45
Price ($):178.0/283.0/1364.0

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Amadis Chemical Company Limited
(CAS:837364-98-4)4,6-Difluoro-2-hydrazono-2,3-dihydropyridine
A864226
Purity:99%/99%/99%
Quantity:250mg/1g/5g
Price ($):178.0/283.0/1364.0
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