Cas no 837-12-7 (1-(4-Bromophenylsulfonyl)-4-methylpiperazine)

1-(4-Bromophenylsulfonyl)-4-methylpiperazine structure

837-12-7 structure

Product Name:1-(4-Bromophenylsulfonyl)-4-methylpiperazine

CAS No:837-12-7

MF:C₁₁H₁₅BrN₂O₂S

MW:319.218000650406

MDL:MFCD00595522

CID:668678

PubChem ID:710729

Update Time:2025-11-02

1-(4-Bromophenylsulfonyl)-4-methylpiperazine Chemical and Physical Properties

Names and Identifiers

- 1-((4-Bromophenyl)sulfonyl)-4-methylpiperazine
- 1-(4-BROMOPHENYLSULFONYL)-4-METHYLPIPERAZINE
- 1-[(4-Bromobenzene)sulfonyl]-4-methylpiperazine
- 1-[(4-bromophenyl)sulfonyl]-4-methyl-piperazine
- Piperazine, 1-[(4-bromophenyl)sulfonyl]-4-methyl-
- HMS537P15
- 1-(4-Bromo-benzenesulfonyl)-4-methyl-piperazine
- 837-12-7
- Oprea1_125382
- SR-01000203347
- CBNDEXDYZUNXBF-UHFFFAOYSA-N
- NCGC00175009-01
- MFCD00595522
- CS-0456099
- TimTec1_000894
- BRD-K85972412-001-01-3
- MB01334
- Z45507420
- SR-01000203347-1
- Oprea1_443452
- 1-(4-bromobenzenesulfonyl)-4-methylpiperazine
- AM87225
- 1-(4-bromophenyl)sulfonyl-4-methylpiperazine
- HMS1536I14
- 1-((p-Bromophenyl)sulfonyl)-4-methylpiperazine
- Cerep_003833
- N-Methyl-N'-(4-bromobenzenesulfonyl)piperazine
- NIOSH/TL0195100
- 1-[(4-bromophenyl)sulfonyl]4-methylpiperazine
- 1-[(4-bromophenyl)sulfonyl]-4-methylpiperazine
- Piperazine, 1-((p-bromophenyl)sulfonyl)-4-methyl-
- SCHEMBL1156725
- 1-bromo-4-[(4-methylpiperazinyl)sulfonyl]benzene
- AKOS003263090
- DTXSID40351821
- AS-2764
- 1-(4-bromo-benzene-sulfonyl)-4-methyl-piperazine
- TL01951000
- N10216
- JHICC02070
- AG-690/10029057
- STK090758
- 1-(4-Bromophenylsulfonyl)-4-methylpiperazine
- MDL： MFCD00595522
- Inchi： 1S/C11H15BrN2O2S/c1-13-6-8-14(9-7-13)17(15,16)11-4-2-10(12)3-5-11/h2-5H,6-9H2,1H3
- InChI Key： CBNDEXDYZUNXBF-UHFFFAOYSA-N
- SMILES： BrC1C=CC(=CC=1)S(N1CCN(C)CC1)(=O)=O

Computed Properties

Exact Mass: 318.00400
Monoisotopic Mass: 318.00376g/mol
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 0
Hydrogen Bond Acceptor Count: 4
Heavy Atom Count: 17
Rotatable Bond Count: 2
Complexity: 339
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
XLogP3: 1.6
Topological Polar Surface Area: 49?2

Experimental Properties

PSA: 49.00000
LogP: 2.34180

1-(4-Bromophenylsulfonyl)-4-methylpiperazine Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
Chemenu	CM169112-25g	1-[(4-Bromobenzene)sulfonyl]-4-methylpiperazine	837-12-7	95%	25g	$458	2021-08-05
Apollo Scientific	OR310452-5g	1-[(4-Bromobenzene)sulfonyl]-4-methylpiperazine	837-12-7		5g	￡183.00	2025-02-20
abcr	AB273400-5 g	1-(4-Bromophenylsulfonyl)-4-methylpiperazine, 95%; .	837-12-7	95%	5g	€283.50	2023-04-26
Chemenu	CM169112-25g	1-[(4-Bromobenzene)sulfonyl]-4-methylpiperazine	837-12-7	95%+	25g	$***	2023-05-29
eNovation Chemicals LLC	D522949-1g	1-((4-BroMophenyl)sulfonyl)-4-Methylpiperazine	837-12-7	97%	1g	$180	2024-05-24
eNovation Chemicals LLC	D522949-5g	1-((4-BroMophenyl)sulfonyl)-4-Methylpiperazine	837-12-7	97%	5g	$198	2024-05-24
abcr	AB273400-1 g	1-(4-Bromophenylsulfonyl)-4-methylpiperazine, 95%; .	837-12-7	95%	1g	€101.70	2023-04-26
TRC	B698638-100mg	1-(4-Bromophenylsulfonyl)-4-methylpiperazine	837-12-7		100mg	$ 64.00	2023-04-18
TRC	B698638-250mg	1-(4-Bromophenylsulfonyl)-4-methylpiperazine	837-12-7		250mg	$ 69.00	2023-04-18
TRC	B698638-500mg	1-(4-Bromophenylsulfonyl)-4-methylpiperazine	837-12-7		500mg	$ 92.00	2023-04-18

1-(4-Bromophenylsulfonyl)-4-methylpiperazine Suppliers

Amadis Chemical Company Limited

Gold Member

Audited Supplier

(CAS:837-12-7)1-(4-Bromophenylsulfonyl)-4-methylpiperazine

Order Number:A864233

Stock Status:in Stock

Quantity:25g

Purity:99%

Pricing Information Last Updated:Friday, 30 August 2024 08:45

Price ($):388.0

Email:[email protected]

Product Official Link

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Additional information on 1-(4-Bromophenylsulfonyl)-4-methylpiperazine

Recent Advances in the Study of 1-(4-Bromophenylsulfonyl)-4-methylpiperazine (CAS: 837-12-7) in Chemical Biology and Pharmaceutical Research

The compound 1-(4-Bromophenylsulfonyl)-4-methylpiperazine (CAS: 837-12-7) has recently garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential therapeutic applications and unique chemical properties. This research briefing aims to provide a comprehensive overview of the latest findings related to this compound, focusing on its synthesis, biological activity, and potential clinical applications. Recent studies have highlighted its role as a promising scaffold for the development of novel drug candidates, particularly in the areas of oncology and central nervous system (CNS) disorders.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers explored the synthesis and optimization of 1-(4-Bromophenylsulfonyl)-4-methylpiperazine derivatives to enhance their pharmacokinetic properties. The study demonstrated that modifications to the sulfonyl group significantly improved the compound's bioavailability and metabolic stability. Additionally, in vitro assays revealed potent inhibitory activity against specific kinase targets implicated in cancer progression, suggesting its potential as a lead compound for anticancer drug development.

Another notable advancement was reported in a 2024 paper in Bioorganic & Medicinal Chemistry Letters, which investigated the compound's interaction with serotonin receptors. The findings indicated that 1-(4-Bromophenylsulfonyl)-4-methylpiperazine exhibits high affinity for 5-HT_2A and 5-HT₆ receptors, making it a candidate for further exploration in the treatment of psychiatric and neurodegenerative disorders. Molecular docking studies further elucidated the binding mechanisms, providing insights for structure-activity relationship (SAR) optimization.

Recent preclinical studies have also shed light on the compound's safety profile and toxicity. A 2023 toxicological assessment published in Regulatory Toxicology and Pharmacology evaluated the acute and subchronic toxicity of 1-(4-Bromophenylsulfonyl)-4-methylpiperazine in animal models. The results indicated a favorable safety profile at therapeutic doses, with no significant adverse effects observed. These findings support its progression to further clinical evaluation.

In conclusion, the latest research on 1-(4-Bromophenylsulfonyl)-4-methylpiperazine (CAS: 837-12-7) underscores its versatility and potential as a therapeutic agent. Its applications span from oncology to CNS disorders, driven by its modifiable chemical structure and promising biological activity. Future studies should focus on clinical trials to validate its efficacy and safety in humans, as well as further SAR studies to optimize its pharmacological properties. This compound represents a compelling area of interest for researchers and pharmaceutical developers alike.

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