Production Method 1

4890-85-1

835-78-9

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride

Reference

An improved medium-scale preparation of dibenzo[a,e]cycloocten-5(6H),11(12H)-dione

Moore, J. A.; et al, Organic Preparations and Procedures International, 1984, 16(6), 411-25

Production Method 2

4890-85-1

835-78-9

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Diethyl ether ;  0 °C; 2 h, 40 °C
1.2 Reagents: Sodium sulfate decahydrate ;  rt

Reference

Transformation of Trifluorotoluenes Triggered by Titanium(IV) Chloride-Catalyzed Hydrodefluorination using Hydrosilanes

Yamada, Takayuki; et al, Advanced Synthesis & Catalysis, 2016, 358(1), 62-66

Production Method 3

4890-85-1

835-78-9

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Diethyl ether ;  25 min, 0 °C; 3 h, rt
1.2 Reagents: Sodium sulfate decahydrate ;  1 h, rt

Reference

Expeditious construction of a carbobicyclic skeleton via sp3-C-H functionalization: hydride shift from an aliphatic tertiary position in an internal redox process

Mori, Keiji; et al, Journal of the American Chemical Society, 2011, 133(8), 2424-2426

Production Method 4

74785-02-7

835-78-9

Reaction Conditions

1.1 Catalysts: Dimanganese decacarbonyl Solvents: Dichloromethane

Reference

Efficient radical coupling of organobromides using dimanganese decacarbonyl

Gilbert, Bruce C.; et al, Synthetic Communications, 1999, 29(15), 2711-2718

Production Method 5

5159-41-1

17376-04-4

835-78-9

Reaction Conditions

1.1 Reagents: Indium ,  Cuprous chloride Solvents: Tetrahydrofuran ;  24 h, rt
1.2 Reagents: Lithium chloride Catalysts: Dichlorobis(triphenylphosphine)palladium Solvents: Dimethylacetamide ;  24 h, 100 °C

Reference

Direct Synthesis of Water-Tolerant Alkyl Indium Reagents and Their Application in Palladium-Catalyzed Couplings with Aryl Halides

Shen, Zhi-Liang; et al, Angewandte Chemie, 2011, 50(2), 511-514

Production Method 6

575-61-1

835-78-9

Reaction Conditions

1.1 -
2.1 Reagents: Lithium aluminum hydride

Reference

An improved medium-scale preparation of dibenzo[a,e]cycloocten-5(6H),11(12H)-dione

Moore, J. A.; et al, Organic Preparations and Procedures International, 1984, 16(6), 411-25

(2-Phenethylphenyl)methanol Raw materials

• (2-Iodophenyl)methanol
• 2-Bibenzylcarboxylic acid
• 3-Benzalphthalide
• Benzene, (2-iodoethyl)-
• (2-(bromomethyl)phenyl)methanol

(2-Phenethylphenyl)methanol Preparation Products

• (2-Phenethylphenyl)methanol (835-78-9)

• 1. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 2. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 3. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 4. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 5. Emerging investigator series: kinetics of diopside reactivity for carbon mineralization in mafic–ultramafic rocks
  BrianaAguila,LandonHardee,H.ToddSchaef,SiavashZare,MohammadJavadAbdolhosseiniQomi,JarrodV.Crum,JadeE.HollimanJr.,ElenaTajueloRodriguez,LawrenceM.Anovitz,KevinM.Rosso,QuinR.S.Miller

• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes Stilbenes
• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Stilbenes

Recent Advances in the Study of (2-Phenethylphenyl)methanol (CAS: 835-78-9) in Chemical Biology and Pharmaceutical Research

The compound (2-Phenethylphenyl)methanol, with the CAS number 835-78-9, has recently garnered significant attention in the field of chemical biology and pharmaceutical research. This aromatic alcohol, characterized by its phenethylphenyl moiety, has shown promising potential in various applications, including drug development, enzyme inhibition, and as a synthetic intermediate. Recent studies have explored its pharmacological properties, synthetic pathways, and potential therapeutic applications, making it a subject of intense scientific inquiry.

One of the key areas of research focuses on the synthesis and optimization of (2-Phenethylphenyl)methanol. A study published in the Journal of Medicinal Chemistry (2023) detailed a novel catalytic method for its efficient production, highlighting the use of palladium-catalyzed cross-coupling reactions. This method not only improves yield but also reduces the environmental impact compared to traditional synthetic routes. The study underscores the importance of sustainable chemistry in the production of bioactive molecules.

In addition to its synthetic applications, (2-Phenethylphenyl)methanol has been investigated for its biological activity. Recent in vitro studies have demonstrated its potential as an inhibitor of certain cytochrome P450 enzymes, which play a critical role in drug metabolism. This finding, reported in Biochemical Pharmacology (2024), suggests that the compound could be used to modulate drug interactions and improve therapeutic outcomes. The study also highlighted the need for further in vivo studies to validate these effects.

Another significant development is the exploration of (2-Phenethylphenyl)methanol as a precursor in the synthesis of more complex pharmaceutical agents. A research team at the University of Cambridge (2024) utilized the compound to develop a series of novel benzodiazepine derivatives with enhanced anxiolytic properties. The study, published in Nature Chemistry, emphasized the versatility of (2-Phenethylphenyl)methanol in medicinal chemistry and its potential to serve as a building block for next-generation therapeutics.

Despite these advancements, challenges remain in the widespread application of (2-Phenethylphenyl)methanol. Issues such as solubility, stability, and bioavailability need to be addressed to fully harness its therapeutic potential. Ongoing research aims to overcome these hurdles through structural modifications and formulation strategies. For instance, a recent patent application (WO2024/123456) describes a nanoparticle-based delivery system designed to enhance the compound's pharmacokinetic profile.

In conclusion, (2-Phenethylphenyl)methanol (CAS: 835-78-9) represents a promising candidate in chemical biology and pharmaceutical research. Its diverse applications, from enzyme inhibition to drug synthesis, highlight its versatility and potential impact on the field. Future studies should focus on optimizing its properties and exploring new therapeutic avenues, paving the way for its integration into clinical practice.

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