Production Method 1

288-32-4

35718-08-2

83395-38-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  1 h, -10 °C; -10 °C → rt; 2 h, rt

Reference

Facile Synthesis of β-Cyclodextrin-Dextran Polymers by "Click" Chemistry

Nielsen, Thorbjorn Terndrup; et al, Biomacromolecules, 2010, 11(7), 1710-1715

Production Method 2

530-62-1

83395-38-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  2 h, rt

Reference

Functionalization of polyfluorene-wrapped carbon nanotubes using thermally cleavable side-chains

Ritaine, Dialia; et al, Journal of Polymer Science (Hoboken, 2022, 60(23), 3199-3211

Production Method 3

530-62-1

83395-38-4

Reaction Conditions

1.1 Solvents: Dichloromethane ;  0 °C; 1 h, 0 °C; 16 h, rt

Reference

Chemoselective esterification and amidation of carboxylic acids with imidazole carbamates and ureas

Heller, Stephen T.; et al, Organic Letters, 2010, 12(20), 4572-4575

1H-Imidazole-1-carboxylicacid,2-propynylester(9CI) Raw materials

• Imidazole
• N,N'-Carbonyldiimidazole
• propargyl chloroformate

1H-Imidazole-1-carboxylicacid,2-propynylester(9CI) Preparation Products

• 1H-Imidazole-1-carboxylicacid,2-propynylester(9CI) (83395-38-4)

• 1. Evolution study of photo-synthesized gold nanoparticles by spectral deconvolution model: a quantitative approach
  Chung-Sung Yang,Mong-Shian Shih,Fang-Yi Chang New J. Chem., 2006,30, 729-735
• 2. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 3. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
• 4. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 5. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Imidazoles Substituted imidazoles

Comprehensive Overview of 1H-Imidazole-1-carboxylic acid, 2-propynyl ester (9CI) (CAS No. 83395-38-4)

1H-Imidazole-1-carboxylic acid, 2-propynyl ester (9CI), with the CAS number 83395-38-4, is a specialized organic compound that has garnered significant attention in the fields of medicinal chemistry and material science. This compound, characterized by its unique imidazole core and propynyl ester functional group, serves as a versatile building block in synthetic applications. Researchers and industry professionals frequently search for terms like "imidazole derivatives," "propynyl ester applications," and "CAS 83395-38-4 uses," reflecting its relevance in modern scientific inquiries.

The molecular structure of 1H-Imidazole-1-carboxylic acid, 2-propynyl ester combines the reactivity of an imidazole ring with the alkyne functionality of a propynyl group. This dual reactivity makes it a valuable intermediate in the synthesis of more complex molecules, particularly in pharmaceutical research. Recent trends in green chemistry and sustainable synthesis have further highlighted the importance of such intermediates, as they often enable more efficient and environmentally friendly reaction pathways. Searches for "sustainable imidazole synthesis" and "green chemistry intermediates" align closely with the applications of this compound.

In the context of drug discovery, 1H-Imidazole-1-carboxylic acid, 2-propynyl ester is often explored for its potential in creating bioactive molecules. The imidazole moiety is a common feature in many FDA-approved drugs, particularly those targeting enzyme inhibition and receptor modulation. This has led to increased interest in queries such as "imidazole-based drug design" and "propynyl ester in medicinal chemistry." The compound's ability to participate in click chemistry reactions, a popular topic in bioconjugation and material science, further enhances its utility.

From a material science perspective, the alkyne group in 1H-Imidazole-1-carboxylic acid, 2-propynyl ester allows for facile incorporation into polymers and other advanced materials. This has spurred interest in searches like "imidazole polymers" and "alkyne-functionalized materials." The compound's potential in creating conductive polymers or self-healing materials is particularly noteworthy, as these areas are at the forefront of nanotechnology research.

The synthesis and handling of 1H-Imidazole-1-carboxylic acid, 2-propynyl ester require careful consideration of its physicochemical properties. Its solubility, stability, and reactivity profile are frequently searched topics, often under terms like "CAS 83395-38-4 solubility" or "imidazole ester stability." Understanding these properties is crucial for optimizing its use in various applications, from catalysis to biomaterial engineering.

In summary, 1H-Imidazole-1-carboxylic acid, 2-propynyl ester (9CI) (CAS No. 83395-38-4) represents a multifaceted compound with broad applicability across scientific disciplines. Its integration into cutting-edge research areas such as drug development, green chemistry, and advanced materials underscores its importance. As interest in imidazole chemistry and alkyne-based reactions continues to grow, this compound is poised to remain a focal point in both academic and industrial settings.

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