Production Method 1

83010-83-7

83010-84-8

Reaction Conditions

1.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, 1 atm, rt

Reference

Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated γ C(sp3)-H Bonds

He, Gang; et al, Angewandte Chemie, 2013, 52(42), 11124-11128

Production Method 2

4964-76-5

83010-84-8

Reaction Conditions

1.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  rt; 1 h, rt
1.2 Reagents: Ammonium hydroxide Solvents: Water ;  neutralized, cooled
2.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, 1 atm, rt

Reference

Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated γ C(sp3)-H Bonds

He, Gang; et al, Angewandte Chemie, 2013, 52(42), 11124-11128

Production Method 3

56-81-5

83010-84-8

Reaction Conditions

1.1 Catalysts: Sodium iodide ;  110 °C → 150 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  150 °C; 45 min, 150 °C
2.1 Reagents: Sulfuric acid ,  Nitric acid Solvents: Water ;  rt; 1 h, rt
2.2 Reagents: Ammonium hydroxide Solvents: Water ;  neutralized, cooled
3.1 Reagents: Hydrogen Catalysts: Palladium Solvents: Methanol ;  overnight, 1 atm, rt

Reference

Use of a Readily Removable Auxiliary Group for the Synthesis of Pyrrolidones by the Palladium-Catalyzed Intramolecular Amination of Unactivated γ C(sp3)-H Bonds

He, Gang; et al, Angewandte Chemie, 2013, 52(42), 11124-11128

7-Methoxyquinolin-8-amine Raw materials

• Glycerol
• 7-Methoxy-8-nitroquinoline
• 7-Methoxyquinoline

7-Methoxyquinolin-8-amine Preparation Products

• 7-Methoxyquinolin-8-amine (83010-84-8)

• 1. Excellent peroxidase mimicking property of CuO/Pt nanocomposites and their application as an ascorbic acid sensor?
  Xinhuan Wang,Shuangfei Cai,Cui Qi Analyst, 2017,142, 2500-2506
• 2. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 4. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090
• 5. Evolution of cellulose into flexible conductive green electronics: a smart strategy to fabricate sustainable electrodes for supercapacitors
  Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143

Recent Advances in the Study of 7-Methoxyquinolin-8-amine (CAS: 83010-84-8): A Comprehensive Research Brief

7-Methoxyquinolin-8-amine (CAS: 83010-84-8) is a quinoline derivative that has garnered significant attention in the field of chemical biology and medicinal chemistry due to its versatile pharmacological properties. Recent studies have explored its potential as a key intermediate in the synthesis of bioactive compounds, as well as its direct applications in therapeutic development. This research brief aims to provide an overview of the latest findings related to this compound, highlighting its chemical properties, biological activities, and emerging applications in drug discovery.

The compound's structural features, including the methoxy and amino functional groups, contribute to its reactivity and ability to interact with biological targets. Recent synthetic methodologies have focused on optimizing the production of 7-Methoxyquinolin-8-amine, with an emphasis on green chemistry principles to reduce environmental impact. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated a novel catalytic approach that improves yield and purity while minimizing waste.

In terms of biological activity, 7-Methoxyquinolin-8-amine has shown promise as a scaffold for developing antimicrobial and anticancer agents. A 2024 study in Bioorganic & Medicinal Chemistry Letters reported that derivatives of this compound exhibited potent inhibitory effects against multidrug-resistant bacterial strains. Additionally, its role in modulating specific signaling pathways, such as the NF-κB pathway, has been investigated for potential anti-inflammatory applications.

Beyond its direct therapeutic potential, 7-Methoxyquinolin-8-amine serves as a critical building block in the synthesis of more complex molecules. Recent work has explored its use in creating fluorescent probes for cellular imaging, leveraging its inherent photophysical properties. This application was detailed in a 2023 ACS Chemical Biology publication, which highlighted the compound's utility in real-time tracking of intracellular processes.

Looking ahead, the versatility of 7-Methoxyquinolin-8-amine positions it as a valuable tool in both academic and industrial research. Ongoing studies are investigating its potential in targeted drug delivery systems and as a component of hybrid molecules designed to address complex diseases. As the field advances, this compound is expected to play an increasingly important role in the development of next-generation therapeutics.

• 214278-21-4(1H-Indol-7-amine,6-methoxy-)
• 1216228-63-5(3-Amino-7-methoxyquinoline dihydrochloride)
• 1033757-39-9(8-amino-7-Quinolinol hydrochloride)
• 648420-74-0(8-Methoxy-7-isoquinolinamine)
• 54620-48-3(5-methoxyquinolin-6-amine)
• 90-52-8(6-methoxyquinolin-8-amine)
• 30465-68-0(5-methoxyquinolin-8-amine)
• 214278-16-7(4-methoxy-1H-Indol-5-amine)
• 87199-83-5(7-Methoxyquinolin-3-amine)
• 881668-93-5(5-methoxyquinolin-3-amine)